DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and grin3a

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	782	Identity:	154/782 - (19%)
Similarity:	281/782 - (35%)	Gaps:	234/782 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 KYRRQAELCTRFTL---NPR---------------------AICRSMPMPD----LYCGSGFTMQ 263
            :::||.:....|.:   ||:                     .:|:.|.:.|    |:..|.|.:.
Zfish   232 EFQRQTQNLLHFQMAMQNPQTSQANLIFSLLSMNNWFDVSLVMCQQMNISDFVFLLHNNSKFHLG 296

  Fly   264 RAMLLNVLRSLINAAQVSPGYPLAIYQDCNAT--ASSSEVSD-----------PLEKDDYNW--- 312
            ..:.::...|..|...:.....|...:|..:|  ....::.|           .|...||:|
Zfish   297 TVLKISTNSSSKNDFHIFLQAQLESIKDSTSTLVTFGCDIRDIRRIFTTIAKFGLILPDYHWIIG 361

  Fly   313 ------------LDMVHWSNFLAYA----PPLPH-IQDQFQ------------SP----VPGLT- 343
                        |.|    ..||:.    |.|.| :||..:            ||    :||.|
Zfish   362 DSQNVEELRTEGLPM----GLLAHGRMGEPSLDHYVQDALELVARAVGSAATVSPQLALIPGTTN 422

  Fly   344 -----FAVNISAGYYSSEHEAKTDL---------------------------------AAWSSVG 370
                 .|.|:::|.:.|.:.|.|..                                 ..|:.:|
Zfish   423 CLARLEAKNLTSGTFLSRYMASTSFDGLSGCISVQEESTIISESHHFIWNLQHDPIGKPMWTRLG 487

  Fly   371 EMR----LLNETISPARR--------------FFRIGTAESIPWSYLR--REEG---TGELIRD- 411
            ..:    :::..:.|.:|              ..|:.|....|:.:.|  .:||   .|:|..|
Zfish   488 SWKHGKVVMDYGVWPNKRRSQPGADWRHSSRLHLRVVTLVEHPFVFTRDVDDEGLCPAGQLCLDP 552

  Fly   412 ------------------RSGLPI-----WEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNEL 453
                              ...:|:     ..|||||.:.:|::.:.|:|::.....|..|....
Zfish   553 LTNDTALLESLFQGLQGANDTVPLEFKKCCYGYCIDLLEKLAEDMGFDFDLYIVGDGKYGAYKN- 616

  Fly   454 GEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLR 518
            |.|.|:||||:.|....|:.:..:.|.|.:||||..|:: .|.:.|.:|.......:..||..|.
Zfish   617 GRWTGLVGDLMSGAAHLAVTSFSINSARSQVIDFTSPFF-STSLGILVRTRDTAAPIGAFMWPLH 680

  Fly   519 LEVWLSIVAALVGTAIMIWFMDKYSPYS----SRNNRQAYPYACREFTLRESFWFALTSFTPQGG 579
            ..:||.|..:|..||:.:...:..||:.    .||..:.:     .|:...:..:|:. |.....
Zfish   681 WSMWLGIFVSLHVTAVFLTLYEWKSPFGMTPRGRNRDRVF-----SFSSALNVCYAIL-FGRTAA 739

  Fly   580 GEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSD 644
            .:.||..:||.|:..:.:|.:..|:|:||||||.:..|:      :.|||:.        :.|..
Zfish   740 IKPPKCWTGRFLMNLWAIFCLFCLSTYTANLAAVMVGEK------TYEQLSG--------IHDPK 790

  Fly   645 THQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFA 709
            .|......:|.         .:..::::|:.|   ..:|...:|.....|..:...:...|:...
Zfish   791 LHHPSQGFRFG---------TVRESSAEDYVK---KSFPEMHEYMRRYNAPTTPDGIDHLKDDPQ 843

  Fly   710 NVDAHENADYAFIHDSAEIKYEITRN---CNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771
            .:|       |||.|.|.:.|....:   .:|...|       |.:.::|.|.|...:|..:.:.
Zfish   844 KLD-------AFIMDKALLDYWAHADKXYISLLLTG-------YGIGLKQNSPLTSNISELVSQY 894

  Fly   772 QKDRFFEELKAKYWNQSNLPNCPLSEDQEGIT------LESLGGVFIATLFGLVLAMM-TLGMEV 829
            :.|.|.:.|..|::..     .|..:....:|      ::...|:|:....|:.|::: |||..:
Zfish   895 KSDGFMDMLHDKWYKV-----VPCGKRSFAVTETLQMGIKHFSGLFVMLCVGVALSLLTTLGEHI 954

  Fly   830 LY 831
            ::
Zfish   955 VH 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	101/452 (22%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	62/310 (20%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	43/273 (16%)
		ANF_receptor	132..452	CDD:279440	41/223 (18%)
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	100/437 (23%)
		Lig_chan	682..941	CDD:278489	62/309 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810