DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and grik1b

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	963	Identity:	227/963 - (23%)
Similarity:	396/963 - (41%)	Gaps:	239/963 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVLLLALRFAGSEVLKI-----TFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTTLTLTRS 64
            ||.|:..:..:..:||:|     |...||:...|    :|......:..|....:.:||||
Zfish    49 LLCLMAEVGLSAQQVLRIGGIFETLENEPISVEE----LAFKFAVTNINRNRTLMPNTTLT---- 105

  Fly    65 EDGLDMQRF------------CEILSTVGASAVIDLTYSHWEEG-YNLVRSLGIGYVRLERIMRP 116
               .|:||.            |:.|: :|.:||...::|..... .::..:|.:.::: .|...|
Zfish   106 ---YDIQRINLFDSFEASRRACDQLA-LGVAAVFGPSHSSSVSAVQSICNALEVPHIQ-TRWKHP 165

  Fly   117 --------FLDMFGDFMRQKRA----------NNVAMVFMNA----------------------- 140
                    :::::.|:....||          ..|.:|:.:|
Zfish   166 SVDNKDSFYINLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGLIRLQELIKAPSRYSIKIKIR 230

  Fly   141 ------RDAVEAMQQMLVGYPFRTLIMDAS-QTDPGQHFLERIRSLRPAPTYIALFARAAAMNGI 198
                  :||...:::|..|..| .:|.|.| ||  ....|:::.|:.....|...|
Zfish   231 QLPTGSKDARPLLKEMKKGKEF-CVIFDCSYQT--AADVLKQLLSMGMMTEYYHFF--------- 283

  Fly   199 FEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTL----NPRAI----------CRSM 249
               ....||:...||             .:|......|.|.|    ||:..          .::.
Zfish   284 ---FTTLDLYSLDLE-------------PFRYSGVNMTGFRLLNIDNPQVASVVEKWSMERLQAP 332

  Fly   250 PMPDLYCGSG-FTMQRAMLLNVLRSLINAAQVSPGYP------------------LAIYQDCNAT 295
            |.|:.....| .|.:.|::.:.:..:..|:|.:....                  ::::::....
Zfish   333 PKPETGLQDGMMTTEAALMYDAVYMVAAASQRASQITVSSLQCHRHKPWRFGSRFISMFKEAQWN 397

  Fly   296 ASSSEV----SDPLEKD-DYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSS 355
            ..:.::    :|.|.|| |   ||::...            :|..:.|:....|
Zfish   398 GLTGQIIINKTDGLRKDFD---LDIISLK------------EDGLEKPLESGRF----------- 436

  Fly   356 EHEAKTDLAAWSSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDR 412
             ::....:..|:|...:.|        .|.|.|.|.|...:.|....|:...::.:      :..
Zfish   437 -NKVWKKIGVWNSNTGLNLTDSNKDKNTNVTDSMANRTLIVTTILENPYVMYKKSD------KPL 494

  Fly   413 SGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKM 477
            .|...:||||:|.:..||..|.|.:|:.....|..|..|:.|||:|:|.:|:....|.|:|.|.:
Zfish   495 YGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYGAQNDKGEWNGMVRELIDHVADLAVAPLTI 559

  Fly   478 YSEREEVIDFLPPYYEQTGISIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDK 541
            ...||:||||..|:. ..||||...|| .....:|.|:..|..::|:.::.|.:|.:.:::.:.:
Zfish   560 TYVREKVIDFSKPFM-TLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIAR 623

  Fly   542 YSPYSSRNNRQAYPYAC--------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLF 598
            ::||...|     |:.|        ..|||..|.||.:.:...||....|||:|.|::...:|.|
Zfish   624 FTPYEWYN-----PHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWFF 683

  Fly   599 VVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMW 663
            .:::::::|||||||||||||.:|:.|.:.||:|::|.|..|:|..|..:|...|.:  |..:||
Zfish   684 TLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIS--TYEKMW 746

  Fly   664 KELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEI 728
               |..:|:                       .::..|.:.:||...|   ...|||.:.:|..|
Zfish   747 ---AFMSSR-----------------------KNTALVKNNREGIQRV---LTTDYALLMESTSI 782

  Fly   729 KYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNC 793
            :|...||||||::|.:...:.|.|....||...|:::.|||:||::.....:|.|:|..:   .|
Zfish   783 EYISQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWRGN---GC 844

  Fly   794 PLSEDQEGITL--ESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQV 844
            |..:.:|...|  |::||:||....||||::.....|.:|..:|.  |:|.:|
Zfish   845 PEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKN--LDIEEV 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	125/411 (30%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	92/307 (30%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	74/460 (16%)
		ANF_receptor	80..423	CDD:279440	63/386 (16%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	125/411 (30%)
		Lig_chan	602..871	CDD:278489	92/307 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910