DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and grin2bb

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	518	Identity:	126/518 - (24%)
Similarity:	227/518 - (43%)	Gaps:	107/518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 YSSEHEAKTDLAAWSSVGEMR-LLNETISPARRFFRIGTA--ESIPW-SYLRREEGTGELIRDRS 413
            ||...|.:.|..:..::.|.. ::.|.:.|..     ||.  .::|. ..|:.:..||:     |
Zfish   474 YSDAEEREDDHLSIVTLEEAPFVIVEDVDPLS-----GTCMRNTVPCRKQLKLQNLTGD-----S 528

  Fly   414 GLPI---WEGYCIDFIIRLSQKLNFEFEIVAPEVG-HMGELNELGEWDGVVGDLVRGETDFAIAA 474
            |:.|   .:|:|||.:.::::.:.|.:::.....| |..::|  |.|:|:||::|......|:.:
Zfish   529 GIYIKRCCKGFCIDILKKIAKSVKFTYDLYLVTNGKHGKKIN--GTWNGMVGEVVLKNAHMAVGS 591

  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWF 538
            |.:..||.|||||..|:.| ||||:.:.:.....|...|:.....:|| :..|..|:.:|:.::.
Zfish   592 LTINEERSEVIDFSVPFIE-TGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFV 655

  Fly   539 MDKYSPYSSRNNRQAYPYAC----RE-----FTLRESFW----FALTSFTPQGGGEAPKAISGRM 590
            .:.:||..  .||      |    ||     ||:.::.|    ....:..|.   :.||..:.::
Zfish   656 FEYFSPVG--YNR------CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPV---QNPKGTTSKI 709

  Fly   591 LVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYT------VVKDSDTHQYF 649
            :|:.:..|.|:.||::|||||||:..|.....|..|.....|...:::      .|.:..|.:
Zfish   710 MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVTGLSDKKFQHPNDFSPPFRFGTVPNGSTER-- 772

  Fly   650 VNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAH 714
                               |...::|:...:.....::        |.::.:...|.|  .:|
Zfish   773 -------------------NIRNNYKEMHSYMTSFHQK--------NVNEALHSLKSG--KLD-- 806

  Fly   715 ENADYAFIHDSAEIKYEITRN--CNLTEVGE--VFAEQPYAVAVQQGSHLGDELSYAILELQKDR 775
                 |||:|:|.:.|...|:  |.|..:|.  :||...|.:|:|:.|.....:..|||:|..|.
Zfish   807 -----AFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIAIQKDSGWKRAVDLAILQLFGDG 866

  Fly   776 FFEELKAKYW------NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYY 832
            ..|||:| .|      |:.|    .:...|  :.::::.|||......:.|:::|...|.|:|
Zfish   867 EMEELEA-LWLTGICHNEKN----EVMSSQ--LDVDNMAGVFYMLGAAMALSLITFIAEHLFY 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	108/439 (25%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	74/327 (23%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373
		ANF_receptor	138..442	CDD:279440
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	112/462 (24%)
		Lig_chan	636..908	CDD:278489	74/327 (23%)
		NMDAR2_C	919..1770	CDD:287527	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810