DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and grik4

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	916	Identity:	230/916 - (25%)
Similarity:	389/916 - (42%)	Gaps:	167/916 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AGSEVLKITFWIEPVQRAEFDTDIAMVLKEL------DALRLDVKVDDTTLTLTRSEDG-LDMQR 72
            |.:.:|.:..|:...........||.:|.:.      :.|.:.:..|....:..||..| |::..
Zfish     4 AWAPLLFLAMWVRNATSGPLSFRIAAILDDPMECSRGERLAITLAKDSINRSSNRSTTGKLEVDI 68

  Fly    73 F--------------CEILSTVGASAVIDLTYSHWEEGY--NLVRSLGIGYVRL--ERIMRPFLD 119
            |              |:|:|. |..||:..:.|......  |:.....:.||::  |.|::....
Zfish    69 FELLRDSEYETGETMCQIMSK-GVVAVLGPSASPASNSIISNICGEKEVPYVKVAPEDILKVQFP 132

  Fly   120 MFGDFMRQKRANNVAM------VFMNARDA------------VEA-MQQMLVGYPFRTL---IMD 162
            .|.....:....:::|      .|.|:..:            :|. ::|.|:..  .||   ::|
Zfish   133 RFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLICAQADCLLNLEVLLRQFLISK--ETLSVRMLD 195

  Fly   163 ASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQ-------RPLEWHFVFLD 220
            .|| || ...|:.||..:.|.  |.:.|.|...:.|.|:..:..:..       ..||:..:.||
Zfish   196 DSQ-DP-TPLLKEIRDDKTAT--IIVDANATMSHVILERASELGMLSVYYTYILTSLEFSLLRLD 256

  Fly   221 --TRDRV----FK-YRRQAELCTRFTLNP----RAICRSMPMPDLYCGSGFTMQRAMLLNVLRSL 274
              ...||    |. :.|.......|.|:.    :..|...|.      :|..:..|:|.:.:.::
Zfish   257 DLADQRVNIVGFSVFNRTHPFFQDFVLSLNRSWQENCDHAPF------AGTPLSSALLFDAVHTV 315

  Fly   275 INAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDD--YNWLDMVHWSNFLAYAPPLPHIQDQFQS 337
            :.|.|     .|...|:..||..|.:.|...|...  .|:|.||.......      ||  :|.|
Zfish   316 VAAVQ-----ELNRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTG------HI--EFNS 367

  Fly   338 PVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRL------LNETISPARRFFRIGTAESIPW 396
            ......:|:.|    ..:..:....:..|.|...:.:      ||.|.:.......|.|....|:
Zfish   368 KGQRSNYALRI----MQNSRDGLRQIGQWHSEQGLSMERKLPSLNVTDTLFNTTLTITTILENPY 428

  Fly   397 SYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVG 461
            ..||...      ::..|...:||:|:|.:..|:..|.|::.|.....|..|.....|.|.|:||
Zfish   429 VMLRANH------QELEGNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYGVPGANGTWTGMVG 487

  Fly   462 DLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPV-RRTSLFKFMTVLRLEVWLSI 525
            :|:..:.|.|:|||.:.:|||:||||..|:. ..||||..|..: ||...|.|:......|||.:
Zfish   488 ELISRKADLAVAALTITAEREKVIDFSKPFM-TLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFM 551

  Fly   526 VAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC---------REFTLRESFWFALTSFTPQGGGE 581
            :.|.:..:.:::.:.:.:||...|     |:.|         .:::|..||||.:..|..||...
Zfish   552 LLAYLAVSCVLFLVARLTPYEWYN-----PHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTI 611

  Fly   582 APKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTH 646
            ||:|:|.|.:...:|.|.:::::::||||||||||:||:.|::|::.||.|:.|.|..:....|.
Zfish   612 APRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTM 676

  Fly   647 QYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGF 708
            .:|.|.::  .|..|||.                             .:.|.||   |...:||.
Zfish   677 TFFQNSRY--QTYQRMWN-----------------------------FMYSKQPSVFVKSTEEGI 710

  Fly   709 ANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQK 773
            |.|   .|::||::.:|...:|...||||||::|.:...:.|.:.:..||...||...|||.||:
Zfish   711 ARV---LNSNYAYLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQE 772

  Fly   774 DRFFEELKAKYWNQSNLPNCPLSEDQ--EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQ 836
            :...|.||.|:|:..   .||..||.  :|:.:|::||:|:..:.||::|:....:|.::..:..
Zfish   773 ENRLEILKRKWWDGG---KCPKEEDHRAKGLGMENIGGIFVVLVCGLLVAIFMAVLEFVWMLRHT 834

  Fly   837 NALEIT 842
            ...|::
Zfish   835 PGTELS 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	128/415 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	94/311 (30%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	81/403 (20%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	126/405 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910