Protein Alignment Ir8a and grik2

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001410875.1
• Gene: grik2 / 556013
• ZFINID: ZDB-GENE-080414-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 1037
• Identity: 249/1037 - (24%)
• Similarity: 415/1037 - (40%)
• Gaps: 277/1037 - (26%)

  Fly     3 LPLLVLLL----------ALRF-----------AGSEVLKITFWIEPVQRAEFDTDIAMVLKELD 46
            |.||:|||          .|||           :|:|.|...|.:..:.|..
Zfish    17 LGLLLLLLCVGYSHGMPHVLRFGGIFESIESGPSGAEELAFKFALNTINRNR------------- 68

  Fly    47 ALRLDVKVDDTTLTLTRSEDGLDMQRF------------CEILSTVGASAVIDLTYSHWEEGYNL 99
                 ..:.:||||       .|:||.            |:.|| :|.:|:...::|   ...|.
Zfish    69 -----TLLPNTTLT-------YDIQRINIHDSFEASRKACDQLS-LGVAAIFGPSHS---SSANA 117

  Fly   100 VRS----LGIGYVRLERIMRP-------FLDMFGDFMRQKRA----------NNVAMVF------ 137
            |:|    ||:.:::.:...:.       :::::.||....||          ..|.:|:
Zfish   118 VQSICNALGVPHIQTKWKHQVSDNRDSFYVNLYPDFSSLSRAILDLVHFFKWKTVTVVYDDSTGL 182

  Fly   138 MNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAM-NGIFEK 201
            :..::.::|..:..:....|.|..|.....|      .::.::....:..:|.....| .||.::
Zfish   183 IRLQELIKAPSRYNIRLKIRQLPADTKDAKP------LLKEMKRGKEFHVIFDCGHEMAAGILKQ 241

  Fly   202 VQKADLFQRPLEWHFVF-------LDTRDRVFKYRRQAELCTRF----TLNPRAI---------- 245
            .....:...  .:|::|       ||    |..||......|.|    |.|.:..
Zfish   242 ALAMGMMTE--YYHYIFTTLDLFALD----VEPYRYSGVNMTGFRILNTENSQVSSIIEKWSMER 300

  Fly   246 CRSMPMPDLYCGSGF-TMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDD 309
            .::.|.||.....|| |...|::.:.:..:..|.|.||...::..| ||....
Zfish   301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVAVAVQQSPQITVSSLQ-CNRHKP------------ 352

  Fly   310 YNW---------LDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNIS----------AGYYSS 355
              |         :...||.                     |||..:|.:          ....|.
Zfish   353 --WRFGNRFMTLIKEAHWD---------------------GLTGRINFNRTNGLRTDFDLDVISL 394

  Fly   356 EHEAKTDLAAWSSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDR 412
            :.|....:..|.....:.:        .|.|.|.:.|...:.|....|:...::.:      :..
Zfish   395 KEEGLEKIGTWDPASGLNMTENQKGKTANVTDSLSNRSLVVSTILEEPYVMFKKSD------KPL 453

  Fly   413 SGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNE-LGEWDGVVGDLVRGETDFAIAALK 476
            .|...:||||:|.:..|:..|.|.:|:...|.|..|..:| .|:|:|:|.:|:..:.|.|:|.|.
Zfish   454 YGNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAPLA 518

  Fly   477 MYSEREEVIDFLPPYYEQTGISIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMD 540
            :...||:||||..|:. ..||||..||| .....:|.|:..|..::|:.|:.|.:|.:.:::.:.
Zfish   519 ITYVREKVIDFSKPFM-TLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIA 582

  Fly   541 KYSPYSSRNNRQAYPYAC--------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWL 597
            ::|||...|     |:.|        ..|||..||||.:.:...||....|||:|.|::...:|.
Zfish   583 RFSPYEWYN-----PHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWF 642

  Fly   598 FVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRM 662
            |.:::::::|||||||||||||::|:.|.:.||:|::|.|.||:|..|..:|...|.:  |..:|
Zfish   643 FTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKIS--TYDKM 705

  Fly   663 WKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAE 727
            |         :|...|                 ..|..|...:||...|   ..:||||:.:|..
Zfish   706 W---------EFMSSR-----------------RHSVMVKSIEEGIERV---LTSDYAFLMESTT 741

  Fly   728 IKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPN 792
            |::...||||||::|.:...:.|.|....||...|:::.|||:||::.....:|.|:|..:   .
Zfish   742 IEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN---G 803

  Fly   793 CPLSEDQEGITL--ESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNA-LE--------ITQVRP 846
            ||..|::|...|  :::||:||....||||::.....|.| ||.|||| ||        :.::|
Zfish   804 CPEEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL-YKSKQNAQLEKRSFCSAMVDELR- 866

  Fly   847 VNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARITL 908
                            .:....::..|.|     :.|..|.........||..::||.:.|:
Zfish   867 ----------------VSLKCQRRLKHKP-----QPPVMVKTDEVINMHTFNDRRLPGKETM 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	130/412 (32%)
grik2	NP_001410875.1	PBP1_iGluR_Kainate	37..414	CDD:380605	75/453 (17%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	130/412 (32%)