DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir8a and Gria1

DIOPT Version :9

Sequence 1:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_113796.1 Gene:Gria1 / 50592 RGDID:621531 Length:907 Species:Rattus norvegicus


Alignment Length:909 Identity:219/909 - (24%)
Similarity:369/909 - (40%) Gaps:212/909 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 WIEPVQRAEFDTDIAMVLKELD-ALRLDVKVDDTTLTLTRSEDGL-----DMQRFCEILSTVGAS 83
            |...|...:.|..::::.:.|| |...:.:|....: ||.:|:|.     |:::..|.|..|...
  Rat   142 WQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNI-LTTTEEGYRMLFQDLEKKKERLVVVDCE 205

  Fly    84 AVIDLTYSHWEEGYNLV-------RSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNAR 141
            :          |..|.:       ...||||..:...: .|:|:..:..::..||......:|..
  Rat   206 S----------ERLNAILGQIVKLEKNGIGYHYILANL-GFMDIDLNKFKESGANVTGFQLVNYT 259

  Fly   142 DAVEA--MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQK 204
            |.:.|  |||      :||       :|...|  .|:...||.      :..|...:|:  ||. 
  Rat   260 DTIPARIMQQ------WRT-------SDSRDH--TRVDWKRPK------YTSALTYDGV--KVM- 300

  Fly   205 ADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRS-MPMPDLYCGSGFTMQRAMLL 268
            |:.||                 ..|||     |..::.|..... :..|.:..|.|..:|||:..
  Rat   301 AEAFQ-----------------SLRRQ-----RIDISRRGNAGDCLANPAVPWGQGIDIQRALQQ 343

  Fly   269 NVLRSLINAAQVS-----PGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPL 328
            .....|....|.:     ..|.|.:.:         ...|.:.|..|       |:.        
  Rat   344 VRFEGLTGNVQFNEKGRRTNYTLHVIE---------MKHDGIRKIGY-------WNE-------- 384

  Fly   329 PHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES 393
               .|:|   ||..|.|   .||                        .:..|...|.:.:.|...
  Rat   385 ---DDKF---VPAATDA---QAG------------------------GDNSSVQNRTYIVTTILE 416

  Fly   394 IPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWD 457
            .|:..|::.....|      |...:||||::....:::.:.:.:.:.....|..|..: :...|:
  Rat   417 DPYVMLKKNANQFE------GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 475

  Fly   458 GVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEV 521
            |:||:||.|..|.|:|.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:
  Rat   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEI 539

  Fly   522 WLSIVAALVGTAIMIWFMDKYSPYS------SRNNRQAYPYACREFTLRESFWFALTSFTPQGGG 580
            |:.||.|.:|.:::::.:.::|||.      .....|.......||.:..|.||:|.:|..||..
  Rat   540 WMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCD 604

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDT 645
            .:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..::...|
  Rat   605 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGST 669

  Fly   646 HQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEG 707
            .::|...|.|.                 |:|  :|.|            :.|::|   |...:||
  Rat   670 KEFFRRSKIAV-----------------FEK--MWTY------------MKSAEPSVFVRTTEEG 703

  Fly   708 FANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771
            ...| ......||::.:|...:| |..:.|:..:||.....:.|.:|..:||.|.:.::.|:|:|
  Rat   704 MIRV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKL 767

  Fly   772 QKDRFFEELKAKYWNQSNLPNCPL----SEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLY 831
            .:....::||.|:|....  .|..    |:|: ..::|.::.|||...:.||.|||:...:|..|
  Rat   768 NEQGLLDKLKNKWWYDKG--ECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 830

  Fly   832 YKKKQ---------------NALEITQVRPVND---SSGSGGNSSTAPPTATSTTKQAWHIPVL 877
            ..:.:               |....|...|.|.   :||.||:.......:....|....||.:
  Rat   831 KSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCM 894

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir8aNP_727328.1 PBP2_iGluR_putative 383..786 CDD:270435 120/414 (29%)
Lig_chan 520..818 CDD:278489 87/312 (28%)
Gria1NP_113796.1 PBP1_iGluR_AMPA_GluR1 26..392 CDD:380613 68/337 (20%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 121/421 (29%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)