Protein Alignment Ir8a and Gria1

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_113796.1
• Gene: Gria1 / 50592
• RGDID: 621531
• Length: 907
• Species: Rattus norvegicus
• Alignment Length: 909
• Identity: 219/909 - (24%)
• Similarity: 369/909 - (40%)
• Gaps: 212/909 - (23%)

  Fly    25 WIEPVQRAEFDTDIAMVLKELD-ALRLDVKVDDTTLTLTRSEDGL-----DMQRFCEILSTVGAS 83
            |...|...:.|..::::.:.|| |...:.:|....: ||.:|:|.     |:::..|.|..|...
  Rat   142 WQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNI-LTTTEEGYRMLFQDLEKKKERLVVVDCE 205

  Fly    84 AVIDLTYSHWEEGYNLV-------RSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNAR 141
            :          |..|.:       ...||||..:...: .|:|:..:..::..||......:|..
  Rat   206 S----------ERLNAILGQIVKLEKNGIGYHYILANL-GFMDIDLNKFKESGANVTGFQLVNYT 259

  Fly   142 DAVEA--MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQK 204
            |.:.|  |||      :||       :|...|  .|:...||.      :..|...:|:  ||.
  Rat   260 DTIPARIMQQ------WRT-------SDSRDH--TRVDWKRPK------YTSALTYDGV--KVM- 300

  Fly   205 ADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRS-MPMPDLYCGSGFTMQRAMLL 268
            |:.||                 ..|||     |..::.|..... :..|.:..|.|..:|||:..
  Rat   301 AEAFQ-----------------SLRRQ-----RIDISRRGNAGDCLANPAVPWGQGIDIQRALQQ 343

  Fly   269 NVLRSLINAAQVS-----PGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPL 328
            .....|....|.:     ..|.|.:.:         ...|.:.|..|       |:.
  Rat   344 VRFEGLTGNVQFNEKGRRTNYTLHVIE---------MKHDGIRKIGY-------WNE-------- 384

  Fly   329 PHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES 393
               .|:|   ||..|.|   .||                        .:..|...|.:.:.|...
  Rat   385 ---DDKF---VPAATDA---QAG------------------------GDNSSVQNRTYIVTTILE 416

  Fly   394 IPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWD 457
            .|:..|::.....|      |...:||||::....:::.:.:.:.:.....|..|..: :...|:
  Rat   417 DPYVMLKKNANQFE------GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 475

  Fly   458 GVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEV 521
            |:||:||.|..|.|:|.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:
  Rat   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEI 539

  Fly   522 WLSIVAALVGTAIMIWFMDKYSPYS------SRNNRQAYPYACREFTLRESFWFALTSFTPQGGG 580
            |:.||.|.:|.:::::.:.::|||.      .....|.......||.:..|.||:|.:|..||..
  Rat   540 WMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCD 604

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDT 645
            .:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..::...|
  Rat   605 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGST 669

  Fly   646 HQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEG 707
            .::|...|.|.                 |:|  :|.|            :.|::|   |...:||
  Rat   670 KEFFRRSKIAV-----------------FEK--MWTY------------MKSAEPSVFVRTTEEG 703

  Fly   708 FANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771
            ...| ......||::.:|...:| |..:.|:..:||.....:.|.:|..:||.|.:.::.|:|:|
  Rat   704 MIRV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKL 767

  Fly   772 QKDRFFEELKAKYWNQSNLPNCPL----SEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLY 831
            .:....::||.|:|....  .|..    |:|: ..::|.::.|||...:.||.|||:...:|..|
  Rat   768 NEQGLLDKLKNKWWYDKG--ECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 830

  Fly   832 YKKKQ---------------NALEITQVRPVND---SSGSGGNSSTAPPTATSTTKQAWHIPVL 877
            ..:.:               |....|...|.|.   :||.||:.......:....|....||.:
  Rat   831 KSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCM 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	120/414 (29%)
Gria1	NP_113796.1	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	68/337 (20%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	121/421 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		6/23 (26%)
		PDZ-binding	904..907