DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and grid2

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	781	Identity:	193/781 - (24%)
Similarity:	319/781 - (40%)	Gaps:	167/781 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 FLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIR 177
            |||...    |...||..:|:.|              |:.|. |||:.::.         |.|.|
Zfish   184 FLDQTSQQGMDVSLQKVESNINM--------------MITGM-FRTMRVEE---------LHRYR 224

  Fly   178 -SLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFV-----FLDTRDRVFKYRRQAELCT 236
             :||.|    .||...|.......:|.:.:|.....:|..:     .:|.::.|.|      ...
Zfish   225 DTLRRA----VLFMSPATAKAFITEVVETNLVAFDCQWIIINEEISDMDVQELVMK------SIG 279

  Fly   237 RFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLA---------IYQDC 292
            |.||    :.::.|:|.      .|.||.:..|   ..||.:...|..|.|         ||...
Zfish   280 RLTL----VRQTFPLPQ------NTSQRCVRNN---HRINTSLCDPKDPKAQMLEITNRYIYDTV 331

  Fly   293 NATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQS----PVPGLTFAVN------ 347
            ...|::..    .:.:|..|..|...|.....:.|....:...::    .|.|||..:.
Zfish   332 LLLANTFH----RKLEDRKWHSMASLSCIRKGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGS 392

  Fly   348 --------ISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARR-------FFRIGTAESIPWS 397
                    :...|........:.||.|..:   ..||.|::..:.       ..|:.|....|:
Zfish   393 NPNIHFEILGTNYGEDRGRGVSRLATWDPI---HGLNGTLTDRKLENNMRGVVLRVVTVLEEPF- 453

  Fly   398 YLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEI-VAPEVGHMGELNELGEWDGVVG 461
            .:..|...|:..:       ::|:.||.:..|:..|.|::|| |||:..: |.....|.|:|::|
Zfish   454 VMVSENVLGKPKK-------YQGFSIDVLDALANYLGFKYEIYVAPDHKY-GSQQADGTWNGLIG 510

  Fly   462 DLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIV 526
            :||....|..::||.:..|||.|:||...|.:.: :.:.:||..|...:|..:....|.:|..|.
Zfish   511 ELVFKRADVGLSALTITPERESVVDFTTRYMDYS-VGVLLRKAERTVDMFACLAPFDLSLWACIA 574

  Fly   527 AA--LVGTAIMI--WFMDKYSPYSSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAIS 587
            ..  ||||.:.:  |......|..|.::.          ||..|.||...||..|||......::
Zfish   575 GTVLLVGTLVYLLNWLNPPRLPMGSVSST----------TLYNSMWFVYGSFVQQGGEVPYTTLA 629

  Fly   588 GRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNM 652
            .||::..:|||.:::::::|||||||||:.|::..:|||:.||:|:.:.|..|.||..:.. |..
Zfish   630 TRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAKQTDLPYGTVLDSAVYDQ-VRS 693

  Fly   653 K----FAEDTLY-RMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVD 712
            |    |..|.:| :||:.:....                         .:...|.::|||...|
Zfish   694 KGMNPFERDPMYSQMWRMINRTG-------------------------GAENNVEESKEGIRKV- 732

  Fly   713 AHENADYAFIHDSAEIKYEI--TRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDR 775
              :...:||:.|:|.::|..  ..:|:|..|....|::.|.:|:|.||...|..|..|||||::.
Zfish   733 --KYGRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQQNG 795

  Fly   776 FFEELKAKYWNQSNLPNC----PLSEDQEGITLE--SLGGVFIATLFGLVLAMMTLGMEVLYYKK 834
            ..:.||.|:|.:.:  .|    |:...:.|..|:  |..|||.....|:||:.:...:|..:.::
Zfish   796 DMDILKLKWWPRDS--PCDLYSPVGTRKSGSALDIHSFAGVFFVLAAGVVLSCLIATVETWWTRR 858

  Fly   835 K 835
            |
Zfish   859 K 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	118/421 (28%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	89/314 (28%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	59/296 (20%)
		ANF_receptor	42..404	CDD:279440	54/270 (20%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	118/414 (29%)
		Lig_chan	568..841	CDD:278489	89/313 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810