Protein Alignment Ir8a and GluRIB

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1003
• Identity: 222/1003 - (22%)
• Similarity: 401/1003 - (39%)
• Gaps: 277/1003 - (27%)

  Fly    61 LTRSEDGLDM---------QRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERI--- 113
            ||.|...||.         |...:.:...|...:|.|..||            .|.:||::|
  Fly   140 LTPSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSH------------DGLLRLQQIYQG 192

  Fly   114 MRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVG-YPFRTLIMDASQTDPGQHFLERIR 177
            :||..:.| .....||.:||:|    |.:.:..::|  :| :..:.:::|.......|..::.:|
  Fly   193 LRPGNESF-QVELVKRISNVSM----AIEFLHTLEQ--IGRFENKHIVLDCPTEMAKQILIQHVR 250

  Fly   178 SLR-PAPTYIALFARAAAMNGIFEKVQKADLFQRPLEW------HFVFLDTRDRVFK-----YRR 230
            .|| ...||..|.: ...|:..:|        ...:|:      .|..:||..|:.:     ::|
  Fly   251 DLRLGRRTYHYLLS-GLVMDDRWE--------SEIIEFGAINITGFRIVDTNRRLVREFYDSWKR 306

  Fly   231 QAELCTRFTLNPRAICRSMPMPDLYCGSG---FTMQRAMLLNVLRSLINA----AQVSPGYPLAI 288
                     |:|:          :..|:|   .:.|.|::.:.:..|:.|    .:..|......
  Fly   307 ---------LDPQ----------MSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNN 352

  Fly   289 YQDCNATASSSEVSDPLEKDDYNW-------------------------------LD---MVHWS 319
            .|..:.|...::.:.....|.||:                               ||   ...|.
  Fly   353 VQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWV 417

  Fly   320 NFLAYAPPLPHIQDQFQSPVPGLTFAVNIS-----AGY-----YSSEHEAKTDLAAWSSVGEMRL 374
            |...:...:.....:.:  :.|||..:..:     ..|     ..:.:.|...:|.|:....::.
  Fly   418 NAWEHGDKISRYLRKVE--IEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQP 480

  Fly   375 LNETISPAR--------RFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQ 431
            ||......|        |.:.:.|....|:..| ::...||.:.   |...:||||.|....|::
  Fly   481 LNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIML-KQVAFGEKLH---GNNRFEGYCKDLADLLAK 541

  Fly   432 KLNFEFEIVAPEVGHMG--ELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQ 494
            :|...:|:...:.|:.|  :.:..|.|||:||:|||.|.|.||||:.:.:|||.||||..|:. .
  Fly   542 ELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFM-S 605

  Fly   495 TGISIAIRKPVRRT-SLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSR-------NNR 551
            .||||.|:|||::| .:|.||..|..|:|:|::.:.:|.:|:::|:.::||:..|       .::
  Fly   606 LGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQ 670

  Fly   552 QAYPYA---------------------------------------------------------CR 559
            ...|:|                                                         ..
  Fly   671 SPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVN 735

  Fly   560 EFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQ 624
            ||::..||||:|.:|..||...:|:::|||:..|:::.|.:::::::|||||||||||||.||:.
  Fly   736 EFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPIN 800

  Fly   625 SLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYG 689
            |.|.||.|:.:.|..:....|..:|..            .::.|:.       ::|:|....:
  Fly   801 SPEDLAMQTEVQYGTLLHGSTWDFFRR------------SQIGLHN-------KMWEYMNSRK-- 844

  Fly   690 HILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRN-CNLTEVGEVFAEQPYAVA 753
            |:.:      |..|  ||...| .:....||.:.:|.:.:|...|. |:..:||.....:.:.:|
  Fly   845 HVFV------PTYD--EGIKRV-RNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIA 900

  Fly   754 VQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE----GITLESLGGVFIAT 814
            ...||.|.|.::.|:|.|:::....:|:.|:|.:.  ..|...:|.|    .::|.::.|:|...
  Fly   901 TPLGSALKDPINLAVLTLKENGELIKLRNKWWYEK--AECSTHKDGETSHSELSLSNVAGIFYIL 963

  Fly   815 LFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSG------------------------- 854
            :.||::::....:|..:..:...:.          |||||
  Fly   964 IGGLLVSVFVAILEYCFRSRDSRSA----------SSGSGMGLGMGLGGGMSGGSLGKANGSMML 1018

  Fly   855 GNSSTAPPTATSTTKQAWHIPVLEAEEK 882
            |.||..|....|:.:::.....:.|:.|
  Fly  1019 GPSSAVPGGMPSSHQRSTLTDTMHAKAK 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	131/478 (27%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	67/388 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	131/477 (27%)
		Lig_chan	630..966	CDD:459656	84/367 (23%)