DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GluRIB

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster

Alignment Length:	1003	Identity:	222/1003 - (22%)
Similarity:	401/1003 - (39%)	Gaps:	277/1003 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LTRSEDGLDM---------QRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERI--- 113
            ||.|...||.         |...:.:...|...:|.|..||            .|.:||::|
  Fly   140 LTPSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSH------------DGLLRLQQIYQG 192

  Fly   114 MRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVG-YPFRTLIMDASQTDPGQHFLERIR 177
            :||..:.| .....||.:||:|    |.:.:..::|  :| :..:.:::|.......|..::.:|
  Fly   193 LRPGNESF-QVELVKRISNVSM----AIEFLHTLEQ--IGRFENKHIVLDCPTEMAKQILIQHVR 250

  Fly   178 SLR-PAPTYIALFARAAAMNGIFEKVQKADLFQRPLEW------HFVFLDTRDRVFK-----YRR 230
            .|| ...||..|.: ...|:..:|        ...:|:      .|..:||..|:.:     ::|
  Fly   251 DLRLGRRTYHYLLS-GLVMDDRWE--------SEIIEFGAINITGFRIVDTNRRLVREFYDSWKR 306

  Fly   231 QAELCTRFTLNPRAICRSMPMPDLYCGSG---FTMQRAMLLNVLRSLINA----AQVSPGYPLAI 288
                     |:|:          :..|:|   .:.|.|::.:.:..|:.|    .:..|......
  Fly   307 ---------LDPQ----------MSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNN 352

  Fly   289 YQDCNATASSSEVSDPLEKDDYNW-------------------------------LD---MVHWS 319
            .|..:.|...::.:.....|.||:                               ||   ...|.
  Fly   353 VQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWV 417

  Fly   320 NFLAYAPPLPHIQDQFQSPVPGLTFAVNIS-----AGY-----YSSEHEAKTDLAAWSSVGEMRL 374
            |...:...:.....:.:  :.|||..:..:     ..|     ..:.:.|...:|.|:....::.
  Fly   418 NAWEHGDKISRYLRKVE--IEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQP 480

  Fly   375 LNETISPAR--------RFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQ 431
            ||......|        |.:.:.|....|:..| ::...||.:.   |...:||||.|....|::
  Fly   481 LNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIML-KQVAFGEKLH---GNNRFEGYCKDLADLLAK 541

  Fly   432 KLNFEFEIVAPEVGHMG--ELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQ 494
            :|...:|:...:.|:.|  :.:..|.|||:||:|||.|.|.||||:.:.:|||.||||..|:. .
  Fly   542 ELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFM-S 605

  Fly   495 TGISIAIRKPVRRT-SLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSR-------NNR 551
            .||||.|:|||::| .:|.||..|..|:|:|::.:.:|.:|:::|:.::||:..|       .::
  Fly   606 LGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQ 670

  Fly   552 QAYPYA---------------------------------------------------------CR 559
            ...|:|                                                         ..
  Fly   671 SPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVN 735

  Fly   560 EFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQ 624
            ||::..||||:|.:|..||...:|:::|||:..|:::.|.:::::::|||||||||||||.||:.
  Fly   736 EFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPIN 800

  Fly   625 SLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYG 689
            |.|.||.|:.:.|..:....|..:|..            .::.|:.       ::|:|....:
  Fly   801 SPEDLAMQTEVQYGTLLHGSTWDFFRR------------SQIGLHN-------KMWEYMNSRK-- 844

  Fly   690 HILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRN-CNLTEVGEVFAEQPYAVA 753
            |:.:      |..|  ||...| .:....||.:.:|.:.:|...|. |:..:||.....:.:.:|
  Fly   845 HVFV------PTYD--EGIKRV-RNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIA 900

  Fly   754 VQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE----GITLESLGGVFIAT 814
            ...||.|.|.::.|:|.|:::....:|:.|:|.:.  ..|...:|.|    .::|.::.|:|...
  Fly   901 TPLGSALKDPINLAVLTLKENGELIKLRNKWWYEK--AECSTHKDGETSHSELSLSNVAGIFYIL 963

  Fly   815 LFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSG------------------------- 854
            :.||::::....:|..:..:...:.          |||||
  Fly   964 IGGLLVSVFVAILEYCFRSRDSRSA----------SSGSGMGLGMGLGGGMSGGSLGKANGSMML 1018

  Fly   855 GNSSTAPPTATSTTKQAWHIPVLEAEEK 882
            |.||..|....|:.:::.....:.|:.|
  Fly  1019 GPSSAVPGGMPSSHQRSTLTDTMHAKAK 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	131/478 (27%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	84/366 (23%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	67/386 (17%)
		ANF_receptor	55..461	CDD:279440	64/369 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	131/477 (27%)
		Lig_chan	632..967	CDD:278489	84/366 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.910