DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and Grik

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	893	Identity:	223/893 - (24%)
Similarity:	378/893 - (42%)	Gaps:	196/893 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PFLDMFGDFMRQKRANNV----AMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERI 176
            ||||...||..|....|:    |.:.:..||.|.|:     |:...|:|.::.:      :|..:
  Fly   119 PFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVAL-----GWESFTIIYESGE------YLPTV 172

  Fly   177 RSL-----RPAPTYIALFARAAAMNG----IFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQA 232
            |.|     ...|| :.:......:||    :..:::.||      ::.||.:.:...:.::.:||
  Fly   173 RELLQMYGTAGPT-VTVRRYELDLNGNYRNVLRRIRNAD------DFSFVVVGSMATLPEFFKQA 230

  Fly   233 ELCTRFTLNPRAICRSMPM------PDLYCGSGFTMQRAMLLNVLRSLINAAQVSPG------YP 285
            :.....|.:.|.|..::..      |..:.|:..|..|.              |||.      ..
  Fly   231 QQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRL--------------VSPDSEQVQEVA 281

  Fly   286 LAIYQ--------DCNATASSSEVSDPLE------------------KDDYNW---LDMVHWSNF 321
            .|:|:        .|..|.|.:.|.|.::                  .||..|   ..:|::...
  Fly   282 KALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKS 346

  Fly   322 L---AYAPPL----PHIQDQFQSPVPGLTFAVNISAGYYSSE--HEAKTDLAAWSSVGEMR-LLN 376
            |   ....|:    ..::..|:..|..|..:.....|.:|.|  .:......|.|...:|| |:|
  Fly   347 LTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVN 411

  Fly   377 ETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVA 441
            ::       |.:.||.|.|:..|:.   |.|.:   .|...:||:.|:.|..||:||.|.:....
  Fly   412 KS-------FVVITAISEPYGMLKE---TSEKL---EGNDQFEGFGIELIDELSKKLGFSYTWRL 463

  Fly   442 PEVGHMGELN-ELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPV 505
            .|....|.:: :.|||:|::.:::....|..|..|.|.||||..:||..|:. ..||.|..|||:
  Fly   464 QEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFM-SLGIGILFRKPM 527

  Fly   506 RR-TSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC--------REF 561
            :. ..||.||:....||||.:..|.:|.:|.::.:.:.||....|     ||.|        .:|
  Fly   528 KEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDN-----PYPCIEEPTELENQF 587

  Fly   562 TLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSL 626
            :.....||::.:...||...||||.|.|.:.|::|.|.:::::::|||||||||||.:.||:...
  Fly   588 SFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDA 652

  Fly   627 EQLAR-QSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGH 690
            :.|:: :..:||.......|..:|....:  .|..||:         :|.:    |.|   ||
  Fly   653 DDLSKNKGGVNYGAKIGGATFNFFKESNY--PTYQRMY---------EFMR----DNP---QY-- 697

  Fly   691 ILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQ 755
               ..|::|      ||   ||..||::|||:.:|..|:|...|.|.||:||.:..|:.|.:|::
  Fly   698 ---MTNTNQ------EG---VDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMR 750

  Fly   756 QGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNC--PLSEDQEGITLE--SLGGVF----I 812
            :.....|.||.|:||:|:.....::|.|:|.:......  ...||...:.||  :|||||    :
  Fly   751 KNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGV 815

  Fly   813 ATLFGLVLAMMTLGMEVLYYKKKQNALEIT-------QVRPVNDSSGSGGNSSTAPPTATSTTKQ 870
            .:.||:.::::.:   ||..|::.:..:::       ::|.:...|   ||:........|:...
  Fly   816 GSFFGIFVSLLEM---VLGVKERSDENQVSFKTELLDEIRFILQCS---GNTKAVKYPKNSSRSN 874

  Fly   871 AWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARITLGDGKFKPRHG 918
            |      .::.|.:.:|.           ..||...:..|...|..||
  Fly   875 A------SSKSKGSSMSV-----------DSLPEDTSEADASGKHNHG 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	130/413 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	96/314 (31%)
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	58/303 (19%)
		ANF_receptor	53..374	CDD:279440	54/286 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	131/420 (31%)
		Lig_chan	543..816	CDD:278489	95/309 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010