DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and KaiR1D

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	950	Identity:	229/950 - (24%)
Similarity:	394/950 - (41%)	Gaps:	235/950 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPLLVLLLAL--RFAGS--EVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTTLTLTR 63
            ||||:|.|.|  |.|.|  :::||.....|   |:...::|. .:.:|.:..|..:      |.|
  Fly     9 LPLLLLQLILNCRKAQSLPDIIKIGGLFHP---ADDHQELAF-RQAVDRINADRSI------LPR 63

  Fly    64 SEDGLDMQRF------------CEILSTVGASAVIDLTYSH--------------------WEEG 96
            |:....::|.            |.:|: :|.:|:.....||                    |:
  Fly    64 SKLVAQIERISPFDSFHAGKRVCGLLN-IGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWD-- 125

  Fly    97 YNLVR------------SLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQ 149
            |.|.|            :|...||              |.:|........:::.| .|.:..:|:
  Fly   126 YRLRRESCLVNLYPHPNTLSKAYV--------------DIVRHWGWKTFTIIYEN-NDGIVRLQE 175

  Fly   150 MLVGY---PFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQ-- 209
            :|..:   ||...:...|.:...:..|::|::  .|..:|.|......::.:.::.|:..:..
  Fly   176 LLKAHGMTPFPITVRQLSDSGDYRPLLKQIKN--SAEAHIVLDCSTERIHEVLKQAQQIGMMSDY 238

  Fly   210 -----RPLEWHFVFLD---------TRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGF 260
                 ..|:.|.|.||         |..|:...:..:::..:::::.:.:.||..:..:...:..
  Fly   239 HSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSETAL 303

  Fly   261 TMQRAMLL-NVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAY 324
            ......|. ..|..|..:.|:.. :|::    |:..::              |.......|::..
  Fly   304 MYDAVHLFAKALHDLDTSQQIDI-HPIS----CDGQST--------------WQHGFSLINYMKI 349

  Fly   325 APPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEA-KTD---------------LAAWSSV---G 370
            .            .:.|||..:..       :|:. :||               :..|:|.   |
  Fly   350 V------------EMKGLTNVIKF-------DHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDG 395

  Fly   371 --------------EMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGY 421
                          |..|.|:|:.       :.|..|.|  |..|:|....|    ||...:|||
  Fly   396 INFTRTFSQKQQEIEANLKNKTLV-------VTTILSNP--YCMRKESAIPL----SGNDQFEGY 447

  Fly   422 CIDFIIRLSQKLNFEFEIVAPEVGHMGELNEL-GEWDGVVGDLVRGETDFAIAALKMYSEREEVI 485
            .:|.|..:|:.|.|.::|.....|..|.||:| |||:|::.:|:....|.|||.|.:..|||:.:
  Fly   448 AVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAV 512

  Fly   486 DFLPPYYEQTGISIAIRKPVRR-TSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRN 549
            ||..|:. ..|:||..|||::: .:||.|::.|.|:||:.:..|.:|.:::::.:.|::||
  Fly   513 DFTTPFM-NLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPY---- 572

  Fly   550 NRQAYPYACRE-----FTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTAN 609
            ...||..|..|     |||....|||:.|...||....|||:|.||:...:|.|.::|::::|||
  Fly   573 EWPAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTAN 637

  Fly   610 LAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDF 674
            ||||||||||.:|::|.|.||:|:||.|..:|...|..:|.:.|.:  |..|||.
  Fly   638 LAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKIS--TYQRMWS---------- 690

  Fly   675 KKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNC 736
                               .:.|::|   .|...||...| |.....|||:.:|..|:|...|||
  Fly   691 -------------------FMESARPSVFTASNGEGVERV-AKGKGSYAFLMESTSIEYVTERNC 735

  Fly   737 NLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQS------NLPNCPL 795
            .||:||.:...:.|.:|....|.....::..||:||::.....||.|:|.:.      .:.....
  Fly   736 ELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKS 800

  Fly   796 SEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKK 835
            |.....:.|.::||||:..:.|:.:|.:....|.::..:|
  Fly   801 SSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	139/412 (34%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	96/311 (31%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	65/433 (15%)
		ANF_receptor	42..378	CDD:279440	58/400 (15%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	141/419 (34%)
		Lig_chan	547..823	CDD:278489	96/311 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.910