DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and gria1b

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	952	Identity:	231/952 - (24%)
Similarity:	402/952 - (42%)	Gaps:	219/952 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PVQRAEFDTDIAMVLKELDALRLDVKVD--DT--TLTLTRSEDGLDMQRFCEILSTVGASAVIDL 88
            |....|:|.....:.:..|..:|..:||  ||  :..:|.:        ||...|. |..|:|.|
Zfish    32 PTDSHEYDVFRFALSQHNDVPKLVPQVDMVDTGSSFAMTYA--------FCSQFSK-GVYAIIGL 87

  Fly    89 TYSHWEEGYNLVRSLGIGYVRLERIMRPF-LDMFGDFMRQKRAN----NVAM---------VFMN 139
               :..:..|::.|. .|.:.:..:...| :|....|:.|.|..    .:|:         |:|.
Zfish    88 ---YDRKTMNMLMSF-CGALHVCFVTPSFPIDTNNQFVIQLRPELQDALIALVEHYKWNKFVYMY 148

  Fly   140 ARDA-VEAMQQML----------VGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTY-IALFARA 192
            :.|: :..:|::|          ....|.||...|        ||:.|:.|.....: |.|....
Zfish   149 SSDSGLTVLQKILDTAAEKTWQVTSINFDTLTEAA--------FLKAIQDLDNKKEFKIILDCEL 205

  Fly   193 AAMNGIFEKV--QKADLFQRPLEWHFV-----FLDTRDRVFKYRRQAELCTRFTL----NPRAIC 246
            ..:|.|...:  ||.:|    ..:|::     |||.  .:.::|:.....|.|.|    || .:.
Zfish   206 ERLNSILNLIAAQKKNL----KNYHYILANLGFLDL--NLTEFRKGGANVTGFQLMNYTNP-TVS 263

  Fly   247 RSM------PMPDL--------YCGS----GFTMQRAMLLNVLRSLI------NAAQVSPGYPLA 287
            |::      ...||        |.|:    |.|:......|:.:..|      ||.:.....|..
Zfish   264 RTIQDWLEFDSKDLKSPKRRLKYTGALTYDGVTVMATAFQNLRKQRIDISRRGNAGECLANPPAP 328

  Fly   288 IYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNF----LAYAPPLPHIQDQFQSPVPGLTFAVNI 348
            ..|..:...:..:|..........:.|..|.:||    :.:.|..|.
Zfish   329 WGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFTVSVMEFGPSGPK------------------ 375

  Fly   349 SAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRS 413
            ..||: ::.|.....|.:|:     :||||.....|.:.:.|....|:..|::..  .:|:
Zfish   376 KVGYW-NQREKYVSTATYSN-----MLNETFGLQNRTYVVTTILEAPYVMLKKNH--EQLV---- 428

  Fly   414 GLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFAIAALKM 477
            |...:||||::....:::.:.:.:.:.....|..|..: |...|:|:||:||.|:.|.|:|.|.:
Zfish   429 GNDKYEGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKADVAVAPLTI 493

  Fly   478 YSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDK 541
            ...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::::.:.:
Zfish   494 TLVREEVIDFSKPFM-SLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 557

  Fly   542 YSPY-----------------------------SSRNNR----QAYPYACREFTLRESFWFALTS 573
            :|||                             .|:|.|    :..|....||.:..|.||:|.:
Zfish   558 FSPYEWHADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGA 622

  Fly   574 FTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYT 638
            |..||...:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|.
Zfish   623 FMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYG 687

  Fly   639 VVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVAD 703
            .:....|.::|...|.|.                 |:|  :|.|            :.|::|...
Zfish   688 TLDGGSTKEFFRRSKIAV-----------------FEK--MWSY------------MKSAEPTVF 721

  Fly   704 AK---EGFANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDEL 764
            .|   ||...| ......||::.:|...:| |..:.|:..:||.....:.|.||..:||.|.:.:
Zfish   722 VKTTDEGVVRV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPV 785

  Fly   765 SYAILELQKDRFFEELKAKYWNQSNLPNCPL----SEDQ-EGITLESLGGVFIATLFGLVLAMMT 824
            :.|:|:|.:....::||.|:|....  .|..    |:|: ..::|.::.|||...:.||.|||:.
Zfish   786 NLAVLKLNEQGLLDKLKNKWWYDKG--ECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLV 848

  Fly   825 LGMEVLYYKKKQNALEITQVRPVNDSS---------GSGGNS 857
            ..:|..|    ::.:|..:::.:.|::         ||||.:
Zfish   849 ALVEFCY----KSRIESRRMKQIIDAAMLSSTLTRMGSGGEN 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	125/441 (28%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	91/339 (27%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	79/401 (20%)
		ANF_receptor	41..368	CDD:279440	71/354 (20%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	126/448 (28%)
		Lig_chan	536..842	CDD:278489	91/339 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910