DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and Ir75d

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	107/509 - (21%)
Similarity:	188/509 - (36%)	Gaps:	125/509 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 QVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHW-SNFLAYAPPLPH----IQDQFQSP 338
            |||....|...|..:|.....:...|   ..::..:..|| ::||  .|.||:    :..:|.|.
  Fly    91 QVSTESSLRDLQHVDALDEHKDAPPP---KSFHANNSTHWETSFL--LPALPYKMGILLLEFSSE 150

  Fly   339 VPGLTFAVNISAGYYSSEHEAKTDLAAW----SSVGEMRLLN--ETISPARRFFRIGTAESI--- 394
            .     |:|:.....:|||...|....|    ...|::.||.  |...|.....|:...|::
  Fly   151 C-----ALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLLEDPEIFIPPDSELRVLHYENVGNF 210

  Fly   395 -----------PWSYLRRE----------------EGTGELI---RDRSGLPIWEGYCIDF---- 425
                       .|..|:|.                :..|..|   :|..|:.......|.|
  Fly   211 SCSLIDLYKVAAWKPLKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLF 275

  Fly   426 ---------------------IIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETD 469
                                 ::.|:.:||..:...  :..:.|.....|.:||::|...|.|.|
  Fly   276 TNIEDLSLRHIDTISKVNHRLMLELANRLNMSYNTY--QTVNYGWRQPNGSFDGLMGRFQRYELD 338

  Fly   470 FAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAI 534
            .|..|:.|..:|..::||:...| :....|..|:|........|......:||:||:..|:.|.:
  Fly   339 LAQLAIFMRLDRIALVDFVAETY-RVRAGIMFRQPPLSAVANIFAMPFENDVWVSILMLLIITTV 402

  Fly   535 MIWFMDKYSPYSSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFV 599
            ::.....:||:   |:..:|         .::..|...:...||.....:..|.|::|...::..
  Fly   403 VLVLELFFSPH---NHDMSY---------MDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAA 455

  Fly   600 VLMLATFTANLAAFLTVERMQTP---VQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDT--- 658
            :.:..:|:||:.|.|     |:|   :|||..|. ||.:...|   .||.  :..:.|.|.|
  Fly   456 LFLFTSFSANIVALL-----QSPSDAIQSLSDLG-QSPLEIGV---QDTQ--YNKIYFTESTDPV 509

  Fly   659 ---LYRMWKELALNASKDF-------KKFR--IWDYPIKEQYGHILLAINSSQP 700
               ||.  |::|......:       :|.|  ::.|.::.|.|:.:::...|:|
  Fly   510 TKNLYH--KKIASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	79/394 (20%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	46/199 (23%)
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	48/203 (24%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	46/199 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910