DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and clumsy

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	907	Identity:	230/907 - (25%)
Similarity:	377/907 - (41%)	Gaps:	241/907 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FDTDIAMVLKEL----DALRLDVKVDDTTLTLTRSEDGLDMQRF----------CEILSTVGASA 84
            ::||     |||    |.|::...:.:.| |:.:...|.|.:.|          |.||.....:.
  Fly   161 YETD-----KELQQLQDILQVGEPISNPT-TVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNL 219

  Fly    85 VIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDM----FGDFMRQKRANNVAMVFMNARDAVE 145
            :..|..:      |.::.||    ..:.:..|.||.    ||: :....||...:..|:..|
  Fly   220 LKILQQA------NELKMLG----EYQSVFIPLLDTHSIDFGE-LSGVEANITTVRLMDPSD--- 270

  Fly   146 AMQQMLVGYPFRTLIMDASQTD--PGQHFL---ERIRS----LRPAPTYIALFARAAAMNGIFEK 201
                    :..:.::.|..:.:  .|::|.   .|::|    |..|   :.||::.....||||:
  Fly   271 --------FHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDA---VWLFSKGLTELGIFEE 324

  Fly   202 VQKADL-FQRPLEWHFVFLDTRDRVFKY--RRQAELCT-RFTLNPRAICRSMPMPDLYCGSGFTM 262
            :...|| .:|...|.|     ..|:.::  .|..|..| |...|... .||.          ||:
  Fly   325 LTAPDLECRRKKPWPF-----GKRIIEFIKARSEETSTGRIDFNENG-QRSF----------FTL 373

  Fly   263 QRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPP 327
             |.|.||           |.|:                            ||:..|
  Fly   374 -RFMELN-----------SDGF----------------------------LDLATW--------- 389

  Fly   328 LPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAE 392
                     .||.||        ...:.:.|::      ..||: :|.|:|       |.:.:..
  Fly   390 ---------DPVNGL--------DVLNDDEESE------KRVGQ-KLSNKT-------FIVSSRL 423

  Fly   393 SIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGE-W 456
            ..|:..| ||...||::   :|...:|||.||.|..:::.|||:||......|..|.||::.: |
  Fly   424 GAPFLTL-REPQEGEIL---TGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTW 484

  Fly   457 DGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRK-PVRRTSLFKFMTVLRLE 520
            ||:|..|:.|..|..|..|.|.|.|.:.:||.||:. ..||||...| |...|.||.|::...|:
  Fly   485 DGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFM-TLGISILFSKPPTPPTDLFSFLSPFSLD 548

  Fly   521 VWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYACRE-------FTLRESFWFALTSFTPQG 578
            ||:.:.:|.:..:::::.:.:.:|....|     |:.|:|       :::..:.|.::.|...||
  Fly   549 VWIYMGSAYLFISLLLFALARMAPDDWEN-----PHPCKEPEEVENIWSIMNTTWLSIGSLMGQG 608

  Fly   579 GGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDS 643
            ....|||.|.|::...:|.|.::||.::|||||||||..|....:.|.|.||.||:|.|..:...
  Fly   609 CDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGG 673

  Fly   644 DTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAK--- 705
            .|..:|.:..|:  |..:||                             .|:.|:.|....|
  Fly   674 STMGFFRDSNFS--TYQKMW-----------------------------TAMESASPSVFTKTND 707

  Fly   706 EGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILE 770
            ||...|...:|. |||:.:|..::|.:.|.|:|.::|.....:.|.:|:...|....::|.|:|:
  Fly   708 EGVERVQKGKNL-YAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLK 771

  Fly   771 LQKDRFFEELKAKYWNQSN-LPNCPLSEDQEGIT----LESLGGVFIATLFGLVLAMMTLGMEVL 830
            |.:.....|||.|:|.:.: ..||..|::..|.|    ||::||||:....|| |:.|.||....
  Fly   772 LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGL-LSAMVLGCTEF 835

  Fly   831 YYKKKQNALE--------------------ITQVRPVNDSSGSGGNSSTAPPTATSTTKQAW 872
            .:..|..|:|                    || .:||:.||.||.::|::  :::|.:|.::
  Fly   836 LWNVKSVAIEEKISLKEAFKSEALFAARIWIT-TKPVHTSSESGSSNSSS--SSSSRSKHSF 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	123/414 (30%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	85/312 (27%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	69/347 (20%)
		ANF_receptor	39..379	CDD:279440	58/265 (22%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	125/421 (30%)
		Lig_chan	548..812	CDD:278489	80/300 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.910