DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GluRIIB

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	1029	Identity:	221/1029 - (21%)
Similarity:	382/1029 - (37%)	Gaps:	293/1029 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVLLLALRFAGSE---VLKI--TFWIEPVQRAEFDTDIAM------VLKELDALRLDVKVDDTT 58
            |::|.||:....:|   |:||  .|         |||::.:      .|:|::|:...:|:|...
  Fly     7 LVLLALAIASGANEDTLVIKIGAIF---------FDTEMKLADAFSAALEEVNAINPALKLDAIK 62

  Fly    59 LTLTRSEDGLDMQRF-CEILSTVGASAVI---DLTYSHWEEGYNLVRSLGIGYVRL--------- 110
            ..:| .:|.:.:|.. |:::.: |.:|:.   ..|.|...|  .|....||.:::.
  Fly    63 RYVT-VDDSIVLQDISCDLIGS-GVAAIFGPSSKTNSDIVE--VLCNMTGIPHLQFDWHPQQSNR 123

  Fly   111 ERI----------MRPFLD-MFGDFMRQK------------RANNV-----AMVFMNARDAVEAM 147
            ||:          |..||. .|.|.:..|            |::::     .:.:.....|...|
  Fly   124 ERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKM 188

  Fly   148 QQMLVGYPFRTL-----------------------IMDAS----QTDPGQH-FLE---------- 174
            |:...|..:|.|                       :::||    .|....| ||.
  Fly   189 QEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGID 253

  Fly   175 --------------RIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTR--- 222
                          |||:..|.|.:                 .:.|:|...::..|..|.::
  Fly   254 GFYSRDFTVAVAAVRIRTYVPPPVH-----------------DEIDVFDNSVDTRFSSLGSQLVY 301

  Fly   223 -DRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYP- 285
             ..|..|....|:..|         ....:|:..||.||......|:..::. |....|.|.:.
  Fly   302 DSIVLFYNALLEISQR---------PGFYIPNFSCGRGFWQPGPRLVEQMKQ-ITPKMVKPPFKT 356

  Fly   286 --LAIYQDCNATASSSEVSDP-LEKDDYNW---LDMVHWSNFLAYAPP------LPHIQDQFQSP 338
              |.|..|......:.||.:| :::..:.|   ..:|.:......:..      |.:.:|..|.|
  Fly   357 QRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKP 421

  Fly   339 VPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREE 403
            : ..|.|..:...|:|                                         |    |||
  Fly   422 I-RYTVATRVGKPYFS-----------------------------------------W----REE 440

  Fly   404 GTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGE 467
            ..|.   ...|...:|||.:|.|..|:|:..|:|..........|..: ...||||::..|:...
  Fly   441 PEGV---HYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNN 502

  Fly   468 TDFAIAALKMYSEREEVIDFLPPYYEQTGISI-AIRKPVRRTSLFKFMTVLRLEVWLSIVAALVG 531
            ....|..|.:...|..|:||..|:. |.|||| :.::|..:..::.|:.....||||.::.|::.
  Fly   503 AQIGICDLTITQARRSVVDFTVPFM-QLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMI 566

  Fly   532 TAIMIWF---MDKY---SPYSSRN---NRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAIS 587
            ||..:.|   :|:|   .|..:.|   .||      ..:.|..:.|..|.|...||....|:.:.
  Fly   567 TAFALIFTGRIDQYEWDQPVENVNREMERQ------NIWHLSNALWLVLGSMLNQGCDLLPRGLP 625

  Fly   588 GRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNM 652
            .|:|.|.:|:|.:|:..|:.|.||||:|..::...:.||..|..|:::.:..::...|..||..
  Fly   626 MRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSE- 689

  Fly   653 KFAEDTLYRM-WKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHE- 715
              :.||..|| |.::.                             |.:|.|..|.....||..:
  Fly   690 --SNDTDNRMAWNKML-----------------------------SFKPDAFTKNNEEGVDRVKL 723

  Fly   716 -NADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEE 779
             ...|||:.::..::|.:.|||.||::||.|.|:.|.:||...:.....||..||.|.:.....:
  Fly   724 SKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFK 788

  Fly   780 LKAKYWNQSNLPNC----PLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE 840
            |:.|::| ||...|    |..:|.: ..::|:||:|:..:.|:|:.::....|.|::.::.:..|
  Fly   789 LRNKWFN-SNESTCDSNVPTIDDGQ-FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKE 851

  Fly   841 ------------------------ITQVRPVNDSSGSGGNSSTAPPTATSTTKQ 870
                                    :...|...||:.:|.:|.....:|:|..|:
  Fly   852 KIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKKK 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	110/416 (26%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	85/313 (27%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	73/406 (18%)
		ANF_receptor	41..378	CDD:279440	65/367 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	114/460 (25%)
		Lig_chan	555..822	CDD:278489	84/306 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.910