DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GluRIIA

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	216/946 - (22%)
Similarity:	360/946 - (38%)	Gaps:	249/946 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DTTLTLTRSEDGLDMQRFCEILSTVG--ASAVIDLTYSHWE-EGYNLVRSLGIGYVRLERIMRPF 117
            |..|..||.|. |:.|....:..::.  :.|..::..|::| ..:.|:.....|..||:
  Fly   123 DLKLEATRQEQ-LNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQ------ 180

  Fly   118 LDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPA 182
                 |.|..:..|:..:...|..|..:         .:|.|..:..:|     |.|:...|...
  Fly   181 -----DLMNIQALNSDYVKLRNLADYAD---------DYRILWKETDET-----FHEQRIILDCE 226

  Fly   183 PTYIALFARAA---AMNGIFEKVQKADLFQRPLEWHFVFLDT-----RD---RVFK--------- 227
            |..:....:.:   .:.|.|.            .|....|||     ||   ..||
  Fly   227 PKTLKELLKVSIDFKLQGPFR------------NWFLTHLDTHNSGLRDIYNEDFKANITSVRLK 279

  Fly   228 ------YRRQAELCTR---------------------FTLNPRAICRSM-PM--PDLYCGSGFT- 261
                  :.|:....|:                     |..:.|.:..:| |.  |:.:|||...
  Fly   280 VVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPW 344

  Fly   262 MQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAP 326
            |..|.::|.::: |:...|.|.:.                ::.::.|:|.  ..:|: |...|.|
  Fly   345 MLGAFIVNEMKT-ISEDDVEPHFK----------------TENMKLDEYG--QRIHF-NLEIYKP 389

  Fly   327 PLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLN---------ETISPA 382
                              .||.....::.::..|           .||||         :..|..
  Fly   390 ------------------TVNEPMMVWTPDNGIK-----------KRLLNLELESAGTTQDFSEQ 425

  Fly   383 RRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHM 447
            |:.:.:.|....|:..::.:.   |..|.|..   :|||.:|.|.:||:.:.|::|.:.  |...
  Fly   426 RKVYTVVTHYEEPYFMMKEDH---ENFRGREK---YEGYAVDLISKLSELMEFDYEFMI--VNGN 482

  Fly   448 GELN-ELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIA-IRKPVRRTSL 510
            |:.| |..:|||::..|:.......:..|.:...|..|:||..|:. |.||||. .:.|....:.
  Fly   483 GKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFM-QLGISILHYKSPPEPKNQ 546

  Fly   511 FKFMTVLRLEVWL-SIVAALVGTAIMIWFMD-KYSPYSSRNNRQAYPYACRE-FTLRESFWFALT 572
            |.|:....:|||: .|.|.|:.|...::... .|..:...|.....|..... :.:..|.|..:.
  Fly   547 FAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVG 611

  Fly   573 SFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINY 637
            |...||....|:....|:|...:|.|.::||:|:|||||||||..:.|:.::||:.|..|.::::
  Fly   612 SIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHF 676

  Fly   638 TVVKDSDTHQYFVNMKFAEDTLY-RMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPV 701
            ..::...|..:|..   :.||.| |.|     |..|||                     |.|...
  Fly   677 GSMRGGSTSLFFSE---SNDTDYQRAW-----NQMKDF---------------------NPSAFT 712

  Fly   702 ADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSY 766
            :..|||.|.| ..|...|||:.::..:.|.|.|||:||::||...|:.|.:||..||.....||.
  Fly   713 STNKEGVARV-RKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSV 776

  Fly   767 AILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEG--ITLESLGGVFIATLFGLVLAMMTLGM-E 828
            :||:|.:....:::|.|:|...|: .|....:.:|  :::..|||||: .|.|.||..:.||: |
  Fly   777 SILQLSERGELQKMKNKWWKNHNV-TCDSYHEVDGDELSIIELGGVFL-VLAGGVLIGVILGIFE 839

  Fly   829 VLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFE 893
            .|                                         |::..:..||   :|:|..:|:
  Fly   840 FL-----------------------------------------WNVQNVAVEE---RVTPWQAFK 860

  Fly   894 -----TATFRGKKLPARITLGDGKFKPRHGLYARRN 924
                 ...|..:|.|.||:....|...|....:||:
  Fly   861 AELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRS 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	118/408 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	91/303 (30%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	60/356 (17%)
		ANF_receptor	46..386	CDD:279440	56/320 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	118/408 (29%)
		Lig_chan	556..828	CDD:278489	91/303 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.910