DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and gria4b

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	889	Identity:	212/889 - (23%)
Similarity:	359/889 - (40%)	Gaps:	220/889 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLER 112
            |:|...:....|:|.   |..|..||..:..|              :.||::          |:.
Zfish   132 LQLRPSIRGALLSLL---DHYDWNRFVFLYDT--------------DRGYSI----------LQA 169

  Fly   113 IMRPFLDMFGDFMRQKRANN----VAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFL 173
            ||            :|...|    .|:...|..||           .:|.|:.|          |
Zfish   170 IM------------EKAGQNGWQVSAICVENFNDA-----------SYRQLLED----------L 201

  Fly   174 ERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVF--LDTRD-RVFKYRRQAELC 235
            :|    |...|:: :...|..:|.:.|::  ..:.:....:|::.  |..:| .:.::.......
Zfish   202 DR----RQEKTFV-IDLEAERLNNMLEQI--VSVGKHVKGYHYIMANLGFKDINLERFMHGGANV 259

  Fly   236 TRFTL----NPRAI----------CRSMP---MPDLYCGSGFTMQRAMLL-----NVLRSLINAA 278
            |.|.|    ||..|          .|..|   .|..|. |..|....|::     |:.|..::.:
Zfish   260 TGFQLVDFSNPMVIKLMQRWNKLDQREYPGSDAPPKYT-SALTYDGVMVMAEAFRNLRRQKVDIS 323

  Fly   279 QVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLT 343
            :      ..|..||.|..::.            |...:.....|...    |:|        |||
Zfish   324 R------RGIAGDCLANPAAP------------WNQGIDMERTLKQV----HLQ--------GLT 358

  Fly   344 FAVNIS-----AGYYSSEHEAKTD----LAAWSSVGEMRLL-------NETISPARRFFRIGTAE 392
            ..|...     ..|.....|.|::    :..|:...::.|.       |||.....|...:.|..
Zfish   359 GNVQFDHYGRRVNYTMDVFELKSNGPRRIGYWNDADKLVLTQDHALLPNETSGMENRTVIVTTIM 423

  Fly   393 SIPWSYLRRE----EGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEI-VAPEVGHMGELNE 452
            ..|:..|::.    ||..:          :||||:|....:::.:.|:::| :.|:..:.....|
Zfish   424 EGPYVMLKKNWEMYEGNEQ----------YEGYCVDLASEIAKHIGFKYKISIVPDGKYGARDPE 478

  Fly   453 LGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTV 516
            ...|:|:||:||.|:.:.|:|.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..
Zfish   479 TKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDP 542

  Fly   517 LRLEVWLSIVAALVGTAIMIWFMDKYSPY-----SSRNNRQAYP--YACREFTLRESFWFALTSF 574
            |..|:|:.||.|.:|.:::::.:.::|||     .........|  ....||.:..|.||:|.:|
Zfish   543 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGTDGLPSDQPPNEFGIFNSLWFSLGAF 607

  Fly   575 TPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTV 639
            ..||...:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..
Zfish   608 MQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTDIAYGT 672

  Fly   640 VKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADA 704
            :....|.::|...|.|   :|.                ::|.|            :.|::|....
Zfish   673 LDSGSTKEFFRRSKIA---VYE----------------KMWSY------------MKSAEPTVFT 706

  Fly   705 K---EGFANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELS 765
            |   ||.|.| ......|||:.:|...:| |..:.|:..:||.....:.|.||..:||.|...::
Zfish   707 KTTAEGVARV-RKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVN 770

  Fly   766 YAILELQKDRFFEELKAKYWNQSNLPNC------PLSEDQEGITLESLGGVFIATLFGLVLAMMT 824
            .|:|:|.:....::||.|:|....  .|      ...:..:.::|.::.|||...:.||.|||:.
Zfish   771 LAVLKLNEQGLLDKLKNKWWYDKG--ECGSGGGGEKDKSSQALSLSNVAGVFYILVGGLGLAMLV 833

  Fly   825 LGMEVLYYKK---KQNALEITQVR------PVNDSSGSGGNSST 859
            ..:|..|..:   |:..|..|:..      .:..|.|..|...|
Zfish   834 ALIEFCYKSRNEAKRMKLTFTEAMRNKARLSITGSVGENGRVLT 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	124/419 (30%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	87/314 (28%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	64/363 (18%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	125/421 (30%)
		Lig_chan	546..827	CDD:306551	87/314 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910