DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and GluRIIE

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	189/776 - (24%)
Similarity:	317/776 - (40%)	Gaps:	178/776 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 NVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMN 196
            |...|....|.:|:.          |.:::.:|:|.|  .||.:.:.:
  Fly   200 NYKQVLRRVRKSVDN----------RIVVVGSSETMP--EFLNQAQQV----------------- 235

  Fly   197 GIFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGF- 260
            ||..:..|..:..  |::|...|:.    :|| .:|.:......:|    ..|.:.:|....|:
  Fly   236 GIINEDYKYIIGN--LDFHSFDLEE----YKY-SEANITGLRLFSP----EKMAVKELLMKLGYP 289

  Fly   261 -------------TMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNW 312
                         |::.|:..:.::......:..|..|:.  |:|:....|       .:||
  Fly   290 TDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMP--QNCSQRTES-------VRDD--- 342

  Fly   313 LDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAK----TDLAAWSSVGEMR 373
                 .|:|..|...|.........|:   .|..|:..||:....|.:    ..:..|....:.|
  Fly   343 -----GSSFKNYMRTLRLTDRLLTGPI---YFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYR 399

  Fly   374 -----------------LLNETISPARRFFRIGTAESIPWSYL----RREEGTGELIRDRSGLPI 417
                             |.|:|      |..:.:..:.|::.|    ::.||..:
  Fly   400 PQRLAPTTAQFDSVDNSLANKT------FIILLSVPNKPYAQLVETYKQLEGNSQ---------- 448

  Fly   418 WEGYCIDFIIRLSQKLNFEFEIVAPEVGH-MGELNE-LGEWDGVVGDLVRGETDFAIAALKMYSE 480
            :|||.:|.|..|:.||.|.|..|  ..|: .|..|: ..|..|::.:::.|..|.||..|.:.||
  Fly   449 YEGYGVDLIKELADKLGFNFTFV--NGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSE 511

  Fly   481 REEVIDFLPPYYEQTGISIAIRKPVRRT-SLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSP 544
            ||:.:||..|:. ..||:|...||.:.| .||.||.....|||..:..:.:|.::..:.:.:.||
  Fly   512 REQALDFTIPFM-NLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSP 575

  Fly   545 YSSRNNRQAYPYAC--------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVL 601
            ....|     ||.|        .:|||..|.||...:...||....|||:|.|.:.:.:|.|.::
  Fly   576 SEWDN-----PYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLI 635

  Fly   602 MLATFTANLAAFLTVERMQTPVQSLEQLA-RQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKE 665
            :::::|||||||||:|:.|:.:.|::.|| .:..:.|...|...|..:|  |..||:...:|
  Fly   636 VVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFF--MTSAEERYKKM--- 695

  Fly   666 LALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKY 730
                     .||               ::.|......|..||...|..  |..|||:.:|..|:|
  Fly   696 ---------NKF---------------MSENPQYLTEDNMEGVNRVKT--NTHYAFLMESTSIEY 734

  Fly   731 EITRNCNLTEVGEVFAEQPYAVAVQQG-SHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCP 794
            ...|.|||.::|:...|:.|.:|:::. .|.| :.:.|:||||:....|::|.|:||:.....|.
  Fly   735 NTKRECNLKKIGDALDEKGYGIAMRKDWPHRG-KFNNALLELQEQGVLEKMKNKWWNEVGTGICA 798

  Fly   795 LSEDQEGIT---LESLGGVFIATLFGLVLAMMTLGM--EVLYYKKKQNALEITQVRPVNDS 850
            ..||....|   :.:|.|||...|.|...|:: .|:  .||:..||.:...:    |:.|:
  Fly   799 TKEDAPDATPLDMNNLEGVFFVLLVGSCCALL-YGIISWVLFVMKKAHHYRV----PLRDA 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	122/419 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	90/310 (29%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	43/255 (17%)
		ANF_receptor	51..382	CDD:279440	42/241 (17%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	124/426 (29%)
		Lig_chan	551..824	CDD:278489	90/309 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.910