DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and Grik3

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	882	Identity:	229/882 - (25%)
Similarity:	364/882 - (41%)	Gaps:	198/882 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 AVIDLTYS-HWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRAN---NVAMVFMNARDAV 144
            |::||..| .|... .:|.....|.:||:.::          |...|.|   .:..:.:::.|:.
  Rat   162 AILDLVQSLKWRSA-TVVYDDSTGLIRLQELI----------MAPSRYNIRLKIRQLPIDSDDSR 215

  Fly   145 EAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQ 209
            ..:::|..|..|| :|.|.|.|...|                 :..:|.||..:.|
  Rat   216 PLLKEMKRGREFR-IIFDCSHTMAAQ-----------------ILKQAMAMGMMTE--------- 253

  Fly   210 RPLEWHFVF-------LDTRDRVFKYRRQAELCTRFTL----NPR--AICRSMPMPDLYCG---- 257
               .:||:|       ||..    .||......|.|.:    ||.  ||.....|..|...
  Rat   254 ---YYHFIFTTLDLYALDLE----PYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRAE 311

  Fly   258 ----SGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHW 318
                .|..|..|.||.....:::.              |...|....|:.........|.....:
  Rat   312 SGLLDGVMMTDAALLYDAVHIVSV--------------CYQRAPQMTVNSLQCHRHKAWRFGGRF 362

  Fly   319 SNFLAYAPPLPHIQDQFQSPVPGLT--FAVNISAG--------YYSSEHEAKTDLAAWS------ 367
            .||:..|        |::    |||  ...|.::|        ..|.:.:....:..||
  Rat   363 MNFIKEA--------QWE----GLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLN 415

  Fly   368 --SVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLS 430
              .|.:.|..|.|.|...|...:.|....|:...|:.:      |...|...:||||||.:..|:
  Rat   416 ITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSD------RTLYGNDRFEGYCIDLLKELA 474

  Fly   431 QKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQT 495
            ..|.|.:||...|.|..|..::.|:|:|:|.:|:..:.|.|:|.|.:...||:.|||..|:. ..
  Rat   475 HILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFM-TL 538

  Fly   496 GISIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC- 558
            |:||..||| ....|:|.|:..|..::|:.::.|.:|.:.:::.:.::|||...:   |:|  |
  Rat   539 GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYD---AHP--CN 598

  Fly   559 -------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616
                   ..|||..||||.:.|...||....|||:|.|::...:|.|.:::::::||||||||||
  Rat   599 PGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTV 663

  Fly   617 ERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWD 681
            |||::|:.|.:.||:|::|.|..|||..|..:|...|.:  |..:||
  Rat   664 ERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKIS--TFEKMW------------------ 708

  Fly   682 YPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFA 746
                        |..||:|.|..|.....:.....||||.:.:|..|:|...||||||::|.:..
  Rat   709 ------------AFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLID 761

  Fly   747 EQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE--GITLESLGG 809
            .:.|.:....||...|:::.|||:||::.....:|.|:|..|   .||..|::|  .:.::.:||
  Rat   762 SKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGS---GCPEEENKEASALGIQKIGG 823

  Fly   810 VFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHI 874
            :||....||||:::....|.:|           ::|...:.......|:.|.....|.|.|.
  Rat   824 IFIVLAAGLVLSVLVAVGEFIY-----------KLRKTAEREQRSFCSTVADEIRFSLTCQR--- 874

  Fly   875 PVLEAEEKPAKVSPPPSFET------ATFRGKKLPAR 905
               ..:.||   .||...:|      .||..::||.:
  Rat   875 ---RLKHKP---QPPMMVKTDAVINMHTFNDRRLPGK 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	131/411 (32%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	96/307 (31%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	62/325 (19%)
		ANF_receptor	55..398	CDD:279440	60/306 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	131/411 (32%)
		Lig_chan	564..832	CDD:278489	96/307 (31%)
		Glutamate binding	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810