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Protein Alignment Ir8a and Gria3

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001106213.1	Gene:	Gria3 / 29628	RGDID:	70958	Length:	888	Species:	Rattus norvegicus

Alignment Length:	917	Identity:	222/917 - (24%)
Similarity:	379/917 - (41%)	Gaps:	239/917 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DTDIAMVLKELDALRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWEEG--- 96
            |.|:..|::...||:                        ..|||.:|        |..||:.
  Rat   126 DADVQFVIQMRPALK------------------------GAILSLLG--------YYKWEKFVYL 158

  Fly    97 YNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANN---VAMVFMNARDAVEAMQQMLVGYPFRT 158
            |:..|    |:..|:.||...:.           ||   .|....|.:|..|          ||.
  Rat   159 YDTER----GFSVLQAIMEAAVQ-----------NNWQVTARSVGNIKDVQE----------FRR 198

  Fly   159 LIMDASQTDPGQHFL----ERIRSL--------RPAPTYIALFARAAAMNGIFEKVQKADL---- 207
            :|.:..:....::.:    |||.::        :.:..|..:.|.....:.:.|:|.....
  Rat   199 IIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITG 263

  Fly   208 FQ-----RPLEWHF----VFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQ 263
            ||     .|:...|    |.||.|:  |...:.|.|.....|...||        |.....|...
  Rat   264 FQIVNNENPMVQQFIQRWVRLDERE--FPEAKNAPLKYTSALTHDAI--------LVIAEAFRYL 318

  Fly   264 RAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPL 328
            |...::|.|      :.|.|       ||.|..:                  |.||..:.....|
  Rat   319 RRQRVDVSR------RGSAG-------DCLANPA------------------VPWSQGIDIERAL 352

  Fly   329 PHIQDQFQSPVPGLT-------------FAVNI---------SAGYYSSEHEAKTDLAAWSSVGE 371
            ..:|      |.|:|             :.:::         .|||: :|:|      .:....:
  Rat   353 KMVQ------VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYW-NEYE------RFVPFSD 404

  Fly   372 MRLLNETISPARRFFRIGTAESIPW-SYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNF 435
            .::.|::.|...|...:.|....|: .|.:..|       ...|...:||||:|....:::.:..
  Rat   405 QQISNDSSSSENRTIVVTTILESPYVMYKKNHE-------QLEGNERYEGYCVDLAYEIAKHVRI 462

  Fly   436 EFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISI 499
            ::::.....|..|..: |...|:|:||:||.|..|.|:|.|.:...|||||||..|:. ..||||
  Rat   463 KYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFM-SLGISI 526

  Fly   500 AIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYS---SRNNR-----QAYP 555
            .|:||.: :..:|.|:..|..|:|:.||.|.:|.:::::.:.::|||.   ..||.     |:.|
  Rat   527 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPP 591

  Fly   556 YACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQ 620
            ....||.:..|.||:|.:|..||...:|:::|||::...:|.|.:::::::|||||||||||||.
  Rat   592 DPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 656

  Fly   621 TPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIK 685
            :|::|.|.||:|:.|.|..:....|.::|...|.|   :|.                ::|.|
  Rat   657 SPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA---VYE----------------KMWSY--- 699

  Fly   686 EQYGHILLAINSSQPVADAK---EGFANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFA 746
                     :.|::|....|   :|.|.| ......:||:.:|...:| |..:.|:..:||....
  Rat   700 ---------MKSAEPSVFTKTTADGVARV-RKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLD 754

  Fly   747 EQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPL----SEDQ-EGITLES 806
            .:.|.||..:||.||:.::.|:|:|.:....::||.|:|....  .|..    |:|: ..::|.:
  Rat   755 SKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKG--ECGSGGGDSKDKTSALSLSN 817

  Fly   807 LGGVFIATLFGLVLAMMTLGMEVLYYKKKQN-ALEITQVRPVNDSSGSGGNSSTAPPTAT---ST 867
            :.|||...:.||.||||...:|..|..:.:: .:::|:         :..|...||.|.|   :|
  Rat   818 VAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTK---------NTQNFKPAPATNTQNYAT 873

  Fly   868 TKQAWHI 874
            .::.:::
  Rat   874 YREGYNV 880

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.