Protein Alignment Ir8a and Gria2

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 566
• Identity: 154/566 - (27%)
• Similarity: 273/566 - (48%)
• Gaps: 82/566 - (14%)

  Fly   342 LTFAVNISAGYYSSEHEAKTD----LAAWSSVGEMRLL-------NETISPARRFFRIGTAESIP 395
            :.:.:||.        |.||:    :..||.|.:|.:.       |:|.....:...:.|....|
  Rat   369 INYTINIM--------ELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESP 425

  Fly   396 WSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGV 459
            :..:::..   |::   .|...:||||:|....:::...|::::.....|..|..: :...|:|:
  Rat   426 YVMMKKNH---EML---EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGM 484

  Fly   460 VGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWL 523
            ||:||.|:.|.|||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:
  Rat   485 VGELVYGKADIAIAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548

  Fly   524 SIVAALVGTAIMIWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGG 580
            .||.|.:|.:::::.:.::|||        ..|..:.:  .:..||.:..|.||:|.:|..||..
  Rat   549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS--ESTNEFGIFNSLWFSLGAFMRQGCD 611

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDT 645
            .:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.|::|:.|.|..:....|
  Rat   612 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGST 676

  Fly   646 HQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEG 707
            .::|...|.|.                 |.|  :|.|            :.|::|   |....||
  Rat   677 KEFFRRSKIAV-----------------FDK--MWTY------------MRSAEPSVFVRTTAEG 710

  Fly   708 FANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771
            .|.| ......||::.:|...:| |..:.|:..:||.....:.|.:|..:||.||..::.|:|:|
  Rat   711 VARV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKL 774

  Fly   772 QKDRFFEELKAKYW---NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYK 833
            .:....::||.|:|   .:....:....|....::|.::.|||...:.||.|||:...:|..|..
  Rat   775 SEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS 839

  Fly   834 KKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEA 879
            :.:.........|.|.:..|..||..     .:|.|:.:::..:|:
  Rat   840 RAEAKRMKVAKNPQNINPSSSQNSQN-----FATYKEGYNVYGIES 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	123/419 (29%)
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	9/36 (25%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	123/421 (29%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877		2/9 (22%)