Protein Alignment Ir8a and GRIN2C

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_016880033.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1337
• Species: Homo sapiens
• Alignment Length: 980
• Identity: 213/980 - (21%)
• Similarity: 341/980 - (34%)
• Gaps: 293/980 - (29%)

  Fly    48 LRLDVKVDDTTLTLTRSEDGLDMQRFCEILS--------TVGASAVIDLTYSHWEEGYNLVRSLG 104
            |:|.|.::.....|.:..:..|...|..|.|        ..|..||.|.::..|.....:...||
Human   215 LQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELG 279

  Fly   105 IG--YVRLERIMRPFLD--MFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQ 165
            .|  ..|.:|::|. ||  :|..:..::.|.   ::|      .||.|..|||
Human   280 PGGPRARTQRLLRQ-LDAPVFVAYCSREEAE---VLF------AEAAQAGLVG------------ 322

  Fly   166 TDPGQHFLERIRSL----RPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRV- 225
              ||..:|....:|    .|..|:..         |:...|.::        |.   |..|.:|
Human   323 --PGHVWLVPNLALGSTDAPPATFPV---------GLISVVTES--------WR---LSLRQKVR 365

  Fly   226 ----------FKYRRQAELCTRFTL-NPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAA- 278
                      ..|.||     ..|| .|...||..|.|.......|          .|.|:|..
Human   366 DGVAILALGAHSYWRQ-----HGTLPAPAGDCRVHPGPVSPAREAF----------YRHLLNVTW 415

  Fly   279 -----QVSPG----YPLAIYQDCNATASSSEVSDPLEKDDYNWLDMV-HWSNFLAYA--PPLPHI 331
                 ..|||    .|..:....|.               :...:|| .|.:.:.|.  |..|..
Human   416 EGRDFSFSPGGYLVQPTMVVIALNR---------------HRLWEMVGRWEHGVLYMKYPVWPRY 465

  Fly   332 QDQFQSPVPG--LTFAVNISAGYYSSEH-EAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES 393
            ....|..|..  ||.|......:...|. :..|.....::|...|..|.|.|         :.:.
Human   466 SASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFS---------SGDV 521

  Fly   394 IPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDG 458
            .|::.|                 ..:|:|||.:.:|::.:.|.:::.....|..|: ...|.|:|
Human   522 APYTKL-----------------CCKGFCIDILKKLARVVKFSYDLYLVTNGKHGK-RVRGVWNG 568

  Fly   459 VVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW- 522
            ::|::.....|.||.:|.:..||.|::||..|:.| ||||:.:.:.....|...|:......||
Human   569 MIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVE-TGISVMVARSNGTVSPSAFLEPYSPAVWV 632

  Fly   523 LSIVAALVGTAIMIWFMDKYSPYS-----SRNNRQAYPYACREFTLRESFW--FALTSFTPQGGG 580
            :..|..|...||.::..:.:||.|     :|..:...|    .||:.:|.|  :||. |......
Human   633 MMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGP----AFTIGKSVWLLWALV-FNNSVPI 692

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE------------------ 627
            |.|:..:.:::|..:..|.|:.||::|||||||:..|:....|..|.
Human   693 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFK 757

  Fly   628 -------------------------QLARQSRINYTVVKDSDTHQYFVNMKFAEDTL--YRMWKE 665
                                     ...|..|.||   :|..||....|.:..||.|  .:|..|
Human   758 TFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNY---RDMHTHMVKFNQRSVEDALTSLKMGSE 819

  Fly   666 LALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKY 730
                                            :|||....:             |||:|:|.:.|
Human   820 --------------------------------AQPVPRKLD-------------AFIYDAAVLNY 839

  Fly   731 EITRN--CNLTEV--GEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLP 791
            ...::  |.|..:  |:|||...|.:|:|:.||....:..|:|:...|...::|:. .|......
Human   840 MAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLET-VWLSGICQ 903

  Fly   792 NCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGME-VLYYKKKQNALEITQV-------RPVN 848
            |.........:.::::.|||...|..:.||::....| ::|:|.:.:....:|:       |.:.
Human   904 NEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIY 968

  Fly   849 DSSGSGGNSSTAP-----PTATSTTKQAWHIPVLEAEE---KPAKVS------------------ 887
             |..||..|..:|     |..|:::.||..:.:|:|..   ..|.||
Human   969 -SCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLDRATRTIENWGGGRR 1032

  Fly   888 -PPPS 891
             ||||
Human  1033 APPPS 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	103/459 (22%)
		Lig_chan	520..818	CDD:278489	78/354 (22%)
GRIN2C	XP_016880033.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810