Protein Alignment Ir8a and GRIN2C

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 980
• Identity: 213/980 - (21%)
• Similarity: 341/980 - (34%)
• Gaps: 293/980 - (29%)

  Fly    48 LRLDVKVDDTTLTLTRSEDGLDMQRFCEILS--------TVGASAVIDLTYSHWEEGYNLVRSLG 104
            |:|.|.::.....|.:..:..|...|..|.|        ..|..||.|.::..|.....:...||
Human   140 LQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELG 204

  Fly   105 IG--YVRLERIMRPFLD--MFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQ 165
            .|  ..|.:|::|. ||  :|..:..::.|.   ::|      .||.|..|||
Human   205 PGGPRARTQRLLRQ-LDAPVFVAYCSREEAE---VLF------AEAAQAGLVG------------ 247

  Fly   166 TDPGQHFLERIRSL----RPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRV- 225
              ||..:|....:|    .|..|:..         |:...|.::        |.   |..|.:|
Human   248 --PGHVWLVPNLALGSTDAPPATFPV---------GLISVVTES--------WR---LSLRQKVR 290

  Fly   226 ----------FKYRRQAELCTRFTL-NPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAA- 278
                      ..|.||     ..|| .|...||..|.|.......|          .|.|:|..
Human   291 DGVAILALGAHSYWRQ-----HGTLPAPAGDCRVHPGPVSPAREAF----------YRHLLNVTW 340

  Fly   279 -----QVSPG----YPLAIYQDCNATASSSEVSDPLEKDDYNWLDMV-HWSNFLAYA--PPLPHI 331
                 ..|||    .|..:....|.               :...:|| .|.:.:.|.  |..|..
Human   341 EGRDFSFSPGGYLVQPTMVVIALNR---------------HRLWEMVGRWEHGVLYMKYPVWPRY 390

  Fly   332 QDQFQSPVPG--LTFAVNISAGYYSSEH-EAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES 393
            ....|..|..  ||.|......:...|. :..|.....::|...|..|.|.|         :.:.
Human   391 SASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFS---------SGDV 446

  Fly   394 IPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDG 458
            .|::.|                 ..:|:|||.:.:|::.:.|.:::.....|..|: ...|.|:|
Human   447 APYTKL-----------------CCKGFCIDILKKLARVVKFSYDLYLVTNGKHGK-RVRGVWNG 493

  Fly   459 VVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW- 522
            ::|::.....|.||.:|.:..||.|::||..|:.| ||||:.:.:.....|...|:......||
Human   494 MIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVE-TGISVMVARSNGTVSPSAFLEPYSPAVWV 557

  Fly   523 LSIVAALVGTAIMIWFMDKYSPYS-----SRNNRQAYPYACREFTLRESFW--FALTSFTPQGGG 580
            :..|..|...||.::..:.:||.|     :|..:...|    .||:.:|.|  :||. |......
Human   558 MMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGP----AFTIGKSVWLLWALV-FNNSVPI 617

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE------------------ 627
            |.|:..:.:::|..:..|.|:.||::|||||||:..|:....|..|.
Human   618 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFK 682

  Fly   628 -------------------------QLARQSRINYTVVKDSDTHQYFVNMKFAEDTL--YRMWKE 665
                                     ...|..|.||   :|..||....|.:..||.|  .:|..|
Human   683 TFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNY---RDMHTHMVKFNQRSVEDALTSLKMGSE 744

  Fly   666 LALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKY 730
                                            :|||....:             |||:|:|.:.|
Human   745 --------------------------------AQPVPRKLD-------------AFIYDAAVLNY 764

  Fly   731 EITRN--CNLTEV--GEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLP 791
            ...::  |.|..:  |:|||...|.:|:|:.||....:..|:|:...|...::|:. .|......
Human   765 MAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLET-VWLSGICQ 828

  Fly   792 NCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGME-VLYYKKKQNALEITQV-------RPVN 848
            |.........:.::::.|||...|..:.||::....| ::|:|.:.:....:|:       |.:.
Human   829 NEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIY 893

  Fly   849 DSSGSGGNSSTAP-----PTATSTTKQAWHIPVLEAEE---KPAKVS------------------ 887
             |..||..|..:|     |..|:::.||..:.:|:|..   ..|.||
Human   894 -SCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLDRATRTIENWGGGRR 957

  Fly   888 -PPPS 891
             ||||
Human   958 APPPS 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	103/459 (22%)
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	65/317 (21%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	114/510 (22%)
		NMDAR2_C	866..>941	CDD:463148	18/75 (24%)