DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir8a and GRIN2B

DIOPT Version :9

Sequence 1:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:908 Identity:192/908 - (21%)
Similarity:338/908 - (37%) Gaps:233/908 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 VQRAEF----DTDIAMVLKELDALRLDVKV------DDTTL-TLTRSEDGLDMQRFCEILSTVGA 82
            |.|.|.    :||...::..:..|..|.|:      |||.. .:.:..|.:..|....||...|.
Human    65 VPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGG 129

  Fly    83 SAVI----DLTYSHWEEGYNLVRSLGIGYVRLER-------IMRPFLDMFGDFMRQKRANNVAMV 136
            |::|    |.:...::.|.::.:...:....:|.       |:..:...:.||:.:.|:      
Human   130 SSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRS------ 188

  Fly   137 FMNARDAVEAMQQMLVGYPF-RTLIMDASQTDPG---QHFLERIRS-------LRPAPTYIALFA 190
                     .::...||:.. ..|::|.|..|..   |:.|::::|       .:...|||...|
Human   189 ---------TIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVA 244

  Fly   191 RAAAMNG-----IFEKVQKADLFQRPL------------EWHF-VFLDTRDRVFKYRRQAELCT- 236
            .:..:.|     |...:...|....|.            ||.: :....||.:      |.:.| 
Human   245 NSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGI------AIITTA 303

  Fly   237 --------RFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGY---PLAIYQ 290
                    .|...|::.|.:.....:|..:   |....|:||.....|.:....||   |..:..
Human   304 ASDMLSEHSFIPEPKSSCYNTHEKRIYQSN---MLNRYLINVTFEGRNLSFSEDGYQMHPKLVII 365

  Fly   291 DCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSS 355
            ..|.......|.        .|.|......:..:....|..::|....:..:|.           
Human   366 LLNKERKWERVG--------KWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTL----------- 411

  Fly   356 EHEAKTDLAAWSSVGEM--RLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIW 418
             .||...:.  .||..:  ..:..|:...:|.......:..| .|:::               ..
Human   412 -EEAPFVIV--ESVDPLSGTCMRNTVPCQKRIVTENKTDEEP-GYIKK---------------CC 457

  Fly   419 EGYCIDFIIRLSQKLNFEFEIVAPEVG-HMGELNELGEWDGVVGDLVRGETDFAIAALKMYSERE 482
            :|:|||.:.::|:.:.|.:::.....| |..::|  |.|:|::|::|......|:.:|.:..||.
Human   458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGKKIN--GTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   483 EVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWFMDKYSPYS 546
            ||:||..|:.| ||||:.:.:.....|...|:.....:|| :..|..|:.:|:.::..:.:||..
Human   521 EVVDFSVPFIE-TGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG 584

  Fly   547 SRNNRQAYPYAC----RE-----FTLRESFW----FALTSFTPQGGGEAPKAISGRMLVAAYWLF 598
              .||      |    ||     ||:.::.|    ....:..|.   :.||..:.:::|:.:..|
Human   585 --YNR------CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPV---QNPKGTTSKIMVSVWAFF 638

  Fly   599 VVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMW 663
            .|:.||::|||||||:..|.....|..|.                       :.||         
Human   639 AVIFLASYTANLAAFMIQEEYVDQVSGLS-----------------------DKKF--------- 671

  Fly   664 KELALNASKDFK-KFRIWDYP-------IKEQYG--HILLAINSSQPVADA----KEGFANVDAH 714
                 ....||. .||....|       |:..|.  |..:...:.:.|.||    |.|  .:|  
Human   672 -----QRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTG--KLD-- 727

  Fly   715 ENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAEQPYAVAVQQGSHLGDELSYAILELQKDR 775
                 |||:|:|.:.|...|:  |.|..:  |:|||...|.:|:|:.|....::..|||:|..|.
Human   728 -----AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDG 787

  Fly   776 FFEELKAKYW------NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYY 832
            ..|||:| .|      |:.|    .:...|  :.::::.|||......:.|:::|...|.|:|
Human   788 EMEELEA-LWLTGICHNEKN----EVMSSQ--LDIDNMAGVFYMLGAAMALSLITFICEHLFY 843

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir8aNP_727328.1 PBP2_iGluR_putative 383..786 CDD:270435 109/441 (25%)
Lig_chan 520..818 CDD:278489 82/335 (24%)
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 64/359 (18%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 115/490 (23%)
HisJ <459..>542 CDD:223904 28/85 (33%)
Lig_chan 557..829 CDD:278489 82/335 (24%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 2/21 (10%)