Protein Alignment Ir8a and GRIN2A

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 959
• Identity: 198/959 - (20%)
• Similarity: 335/959 - (34%)
• Gaps: 314/959 - (32%)

  Fly    23 TFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGA----- 82
            |.| .|.|.|              .|.|||.|  ..|.:.|::....:...|:::|  ||
Human   105 TLW-GPEQAA--------------GLPLDVNV--VALLMNRTDPKSLITHVCDLMS--GARIHGL 150

  Fly    83 -----------SAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMV 136
                       :.::|...||     ..|..|||                         :..|.:
Human   151 VFGDDTDQEAVAQMLDFISSH-----TFVPILGI-------------------------HGGASM 185

  Fly   137 FMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEK 201
            .|..:|......|.......:..:|.....|...|....:.::.|.......|.:....|..
Human   186 IMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSF--- 247

  Fly   202 VQKADLFQRPLEWHFVFLDTRDRVFK-YRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRA 265
                      :.|....:.|.|..|: .:.|.:|        :.|..|:.:  |||...   :..
Human   248 ----------VGWDMQNVITLDTSFEDAKTQVQL--------KKIHSSVIL--LYCSKD---EAV 289

  Fly   266 MLLNVLRSL----------------INAAQVSPGYPLAI----YQDCN--------------ATA 296
            ::|:..|||                .|...:...:|..:    |.|.:              .||
Human   290 LILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTA 354

  Fly   297 SSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQ----DQFQSP-VPGLT---FAVNIS---- 349
            :||    .|||..|                 :|..:    .|.:.| ||..|   |.||::
Human   355 ASS----MLEKFSY-----------------IPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGK 398

  Fly   350 ------AGY----------YSSEHEAKTDLAAWSSVGEMRLLNETIS----------------PA 382
                  .||          .:.:.|       |..||:..  |.|:|                |.
Human   399 DLSFTEEGYQVHPRLVVIVLNKDRE-------WEKVGKWE--NHTLSLRHAVWPRYKSFSDCEPD 454

  Fly   383 RRFFRIGTAESIPW---------------------SYLRREEGTGELIRDRSGLPI---WEGYCI 423
            .....|.|.|..|:                     .:::....|.|      |:.:   .:|:||
Human   455 DNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNE------GMNVKKCCKGFCI 513

  Fly   424 DFIIRLSQKLNFEFEIVAPEVG-HMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDF 487
            |.:.:||:.:.|.:::.....| |..::|.:  |:|::|::|......|:.:|.:..||.||:||
Human   514 DILKKLSRTVKFTYDLYLVTNGKHGKKVNNV--WNGMIGEVVYQRAVMAVGSLTINEERSEVVDF 576

  Fly   488 LPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWFMDKYSPYSSRNN- 550
            ..|:.| ||||:.:.:.....|...|:......|| :..|..|:.:||.::..:.:||.....|
Human   577 SVPFVE-TGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNL 640

  Fly   551 -RQAYPYACREFTLRESFW----FALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANL 610
             :...|:. ..||:.::.|    ....:..|.   :.||..:.:::|:.:..|.|:.||::||||
Human   641 AKGKAPHG-PSFTIGKAIWLLWGLVFNNSVPV---QNPKGTTSKIMVSVWAFFAVIFLASYTANL 701

  Fly   611 AAFLTVERMQTPVQSLEQLARQSRINYT------VVKDSDTHQYFVNMKFAEDTLYRMWKELALN 669
            |||:..|.....|..|.....|...:|:      .|.:..|.:...|
Human   702 AAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRN------------------ 748

  Fly   670 ASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADA----KEGFANVDAHENADYAFIHDSAEIKY 730
                       :||...||    :...:.:.|.||    |.|  .:|       |||:|:|.:.|
Human   749 -----------NYPYMHQY----MTKFNQKGVEDALVSLKTG--KLD-------AFIYDAAVLNY 789

  Fly   731 EITRN--CNLTEVGE--VFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYW------ 785
            :..|:  |.|..:|.  :||...|.:|:|:||....::..|:|:...|...|||:. .|
Human   790 KAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELET-LWLTGICH 853

  Fly   786 NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKK 834
            |:.|    .:...|  :.::::.|||......:.|:::|...|.|:|.|
Human   854 NEKN----EVMSSQ--LDIDNMAGVFYMLAAAMALSLITFIWEHLFYWK 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	107/454 (24%)
		Lig_chan	520..818	CDD:278489	76/324 (23%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810