Protein Alignment Ir8a and GRIN1

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_005266130.1
• Gene: GRIN1 / 2902
• HGNCID: 4584
• Length: 959
• Species: Homo sapiens
• Alignment Length: 912
• Identity: 196/912 - (21%)
• Similarity: 339/912 - (37%)
• Gaps: 272/912 - (29%)

  Fly    33 EFD------TDIAMVLKELDALRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYS 91
            :||      |.:.|..|||:|         ..:.|:.|||        :..:...|:|::::|
Human   217 QFDPGTKNVTALLMEAKELEA---------RVIILSASED--------DAATVYRAAAMLNMT-- 262

  Fly    92 HWEEGYNLVRSLGIGYVRL--ERIMRPFLDMFGDFMRQKRANNVAMVFMNAR-------DAVEAM 147
                        |.|||.|  ||      ::.|:.:|......:.:..:|.:       |||..:
Human   263 ------------GSGYVWLVGER------EISGNALRYAPDGILGLQLINGKNESAHISDAVGVV 309

  Fly   148 QQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPL 212
            .|.:     ..|:...:.|||.:..:......:..|.:..:...:...:|:..:|:
Human   310 AQAV-----HELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVE--------- 360

  Fly   213 EWHFVFLDTRDRVF-KYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLIN 276
                 |.:..||.| .|                             |...:|...|:.|  .:.|
Human   361 -----FNEDGDRKFANY-----------------------------SIMNLQNRKLVQV--GIYN 389

  Fly   277 AAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMV--HWSNFLAYAPPLPHIQDQFQSPV 339
            ...|.|       .|........|...|........|.:|  |...|:...|.|
Human   390 GTHVIP-------NDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTL----------- 436

  Fly   340 PGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEG 404
                     |.|....|.....|                  |.::....|..::.|.|
Human   437 ---------SDGTCKEEFTVNGD------------------PVKKVICTGPNDTSPGS------- 467

  Fly   405 TGELIRDRSGLP-IWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELG-----EWDGVVGDL 463
                  .|..:| ...|:|||.:|:|::.:||.:|:.....|..|....:.     ||:|::|:|
Human   468 ------PRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 526

  Fly   464 VRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAA 528
            :.|:.|..:|.|.:.:||.:.|:|..|:..| |::|.::|.:.|::|..||...:..:||.:..:
Human   527 LSGQADMIVAPLTINNERAQYIEFSKPFKYQ-GLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLS 590

  Fly   529 LVGTAIMIWFMDKYSPY------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGE-APKAI 586
            :...|:|::.:|::||:      |......|       .||..:.||:.......|.|| ||::.
Human   591 VHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA-------LTLSSAMWFSWGVLLNSGIGEGAPRSF 648

  Fly   587 SGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE--QLARQS-RINYTVVKDSDTHQY 648
            |.|:|...:..|.::::|::||||||||.::|.:..:..:.  :|...| :..|..||.|....|
Human   649 SARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIY 713

  Fly   649 FVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDA 713
            | ..:....|:||..:                    |..|.....||   |.|.|
Human   714 F-RRQVELSTMYRHME--------------------KHNYESAAEAI---QAVRD---------- 744

  Fly   714 HENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFE 778
              |..:|||.|||.:::|.::.|:|...||:|....:.:.:::.|.....:|.:||:..::.|.|
Human   745 --NKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFME 807

  Fly   779 ELKAKYW-------NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLY----- 831
            :|. |.|       ::||.|        ..:|.|::.|||:....|:|..:..:.:|:.|
Human   808 DLD-KTWVRYQECDSRSNAP--------ATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKD 863

  Fly   832 YKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETAT 896
            .::||..|....|                         ..|...:  .:.|..:..|.|. :.||
Human   864 ARRKQMQLAFAAV-------------------------NVWRKNL--QDRKSGRAEPDPK-KKAT 900

  Fly   897 FR 898
            ||
Human   901 FR 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	110/425 (26%)
		Lig_chan	520..818	CDD:278489	80/314 (25%)
GRIN1	XP_005266130.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	49/280 (18%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	121/499 (24%)
		CaM_bdg_C0	856..884	CDD:402271	6/54 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910