DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and GRIK5

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	968	Identity:	227/968 - (23%)
Similarity:	381/968 - (39%)	Gaps:	263/968 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTT---------LTL 61
            |:|||.:.||...                       .:.|.:||:...:||.|         |.|
Human     5 LLLLLIVAFASPS-----------------------CQVLSSLRMAAILDDQTVCGRGERLALAL 46

  Fly    62 TRSE---------------DGLDMQR---------FCEIL------------STVGASAV----- 85
            .|.:               |..::||         .|:||            |...||.|
Human    47 AREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICG 111

  Fly    86 ---------------------------------IDLTYSHWEEGYN-----LVRSLGIGYVRLER 112
                                             :.|..|...:.:|     |:.:.....:|||.
Human   112 EKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEE 176

  Fly   113 IMRPFL--------DMFGD------FMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDA 163
            ::|.||        .|..|      .:::.|.:.|:.:.::|..::..:           ::..|
Human   177 LVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHL-----------ILRKA 230

  Fly   164 SQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFE---KVQKADLF--QRPLEWHFVFLDTRD 223
            |:......|.:.|.:....|        ...::||.|   .:....:|  ..|....||    |.
Human   231 SELGMTSAFYKYILTTMDFP--------ILHLDGIVEDSSNILGFSMFNTSHPFYPEFV----RS 283

  Fly   224 RVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAI 288
            ....:|...|..|  .|.| |:..::....::          ::::.:|.| |.:|.....|||
Human   284 LNMSWRENCEAST--YLGP-ALSAALMFDAVH----------VVVSAVREL-NRSQEIGVKPLA- 333

  Fly   289 YQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYY 353
                   .:|:.:. |......|:|.||.:.....        :.:|.|......:.:.|    .
Human   334 -------CTSANIW-PHGTSLMNYLRMVEYDGLTG--------RVEFNSKGQRTNYTLRI----L 378

  Fly   354 SSEHEAKTDLAAWSSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIR 410
            ....:...::..|.|...:.:        |::|:  |.:...:.|....|  |:.|......|
Human   379 EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTL--ANKTLVVTTILENP--YVMRRPNFQAL-- 437

  Fly   411 DRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLV-RGETDFAIAA 474
              ||...:||:|:|.:..|::.|.|.:.:...|.|..|.....|.|.|:||:|: |.:.|.|:||
Human   438 --SGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500

  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWF 538
            ..:.:|||:||||..|:. ..||||..|..: |:...|.|:......|||.::.|.:..:.:::.
Human   501 FTITAEREKVIDFSKPFM-TLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFL 564

  Fly   539 MDKYSPYSSRNNRQAYPYAC---------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAA 594
            ..:.|||...|     |:.|         .::||..|.||.:..|..||....|:|:|.|.:...
Human   565 AARLSPYEWYN-----PHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGV 624

  Fly   595 YWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTL 659
            :|.|.:::::::||||||||||:||:.||:|.:.||.|:.|.|..:....|..:|.|.::  .|.
Human   625 WWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRY--QTY 687

  Fly   660 YRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAF 721
            .|||..:                             .|.||   |...:||.|.|   .|:.|||
Human   688 QRMWNYM-----------------------------QSKQPSVFVKSTEEGIARV---LNSRYAF 720

  Fly   722 IHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWN 786
            :.:|...:|....|||||::|.:...:.|.:.:..||...||::.|||:||::...|.||.|:|.
Human   721 LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE 785

  Fly   787 QSNLPNCPLSEDQ--EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEIT 842
            ..   .||..||.  :|:.:|::||:||..:.||::|:....||.::..::....|.|
Human   786 GG---RCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEET 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	129/416 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	96/311 (31%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	69/431 (16%)
		ANF_receptor	42..379	CDD:279440	63/394 (16%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	129/416 (31%)
		Lig_chan	546..816	CDD:278489	96/311 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910