DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and GRIK4

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	821	Identity:	204/821 - (24%)
Similarity:	342/821 - (41%)	Gaps:	172/821 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRP 211
            ::|.|:.....::.|.....|| ...|:.||..:.|.  |.:.|.|:..:.|..|.  |:|....
Human   179 LRQFLISKDTLSVRMLDDTRDP-TPLLKEIRDDKTAT--IIIHANASMSHTILLKA--AELGMVS 238

  Fly   212 LEWHFVFLDTR-----------DRV----FKYRRQA-----ELCTRFTLNPRAICRSMPMPDLYC 256
            ..:.::|.:..           |||    |....|:     |.......:.:..|..:|.
Human   239 AYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPF----- 298

  Fly   257 GSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVS-DPLEKDD----------Y 310
             :|..:..|:|.:.:.:::.|.           |:.|   .|.|:. .||....          .
Human   299 -TGPALSSALLFDAVYAVVTAV-----------QELN---RSQEIGVKPLSCGSAQIWQHGTSLM 348

  Fly   311 NWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNI---------SAGYYSSEHEAKTDLAAW 366
            |:|.||.......      ||  :|.|......:|:.|         ..|.:........|...:
Human   349 NYLRMVELEGLTG------HI--EFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLY 405

  Fly   367 SSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQ 431
            :|.....|.|.|:.       :.|....|:..|:...      ::..|...:||:|:|.:..|::
Human   406 ASNISDTLFNTTLV-------VTTILENPYLMLKGNH------QEMEGNDRYEGFCVDMLKELAE 457

  Fly   432 KLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTG 496
            .|.|.::|.....|..|.....|.|.|:||:|:..:.|.|:|.|.:.:|||:||||..|:. ..|
Human   458 ILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFM-TLG 521

  Fly   497 ISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC-- 558
            |||..|..: |:...|.|:......|||.::.|.:..:.:::.:.:.:||...:     |:.|
Human   522 ISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYS-----PHPCAQ 581

  Fly   559 -------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616
                   .:::|..|.||.:..|..||...||:|:|.|.:...:|.|.:::::::||||||||||
Human   582 GRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTV 646

  Fly   617 ERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWD 681
            :||..|::|::.||.|:.|.|..:....:..:|.|.::  .|..|||..:
Human   647 QRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRY--QTYQRMWNYM--------------- 694

  Fly   682 YPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGE 743
                          .|.||   |...:||.|.|   .|::|||:.:|...:|...||||||::|.
Human   695 --------------YSKQPSVFVKSTEEGIARV---LNSNYAFLLESTMNEYYRQRNCNLTQIGG 742

  Fly   744 VFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQ--EGITLES 806
            :...:.|.:.:..||...||...|||:||::...|.||.|:|...   .||..||.  :|:.:|:
Human   743 LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGG---KCPKEEDHRAKGLGMEN 804

  Fly   807 LGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE-------ITQVRPV---NDSSGSGGNSSTAP 861
            :||:|:..:.||::|:....:|.|:..:...|.|       :|::|.:   .||.......:..|
Human   805 IGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVP 869

  Fly   862 PTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKL 902
            |..          |.:..|.:|.        .|||....||
Human   870 PPR----------PPIPEERRPR--------GTATLSNGKL 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	122/415 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	92/311 (30%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	46/253 (18%)
		ANF_receptor	43..382	CDD:279440	45/235 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	124/422 (29%)
		Lig_chan	547..816	CDD:278489	92/310 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910