DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir8a and GRIK3

DIOPT Version :9

Sequence 1:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_000822.2 Gene:GRIK3 / 2899 HGNCID:4581 Length:919 Species:Homo sapiens


Alignment Length:882 Identity:229/882 - (25%)
Similarity:364/882 - (41%) Gaps:198/882 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 AVIDLT-YSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRAN---NVAMVFMNARDAV 144
            |::||. |..|... .:|.....|.:||:.::          |...|.|   .:..:.:::.|:.
Human   162 AILDLVQYLKWRSA-TVVYDDSTGLIRLQELI----------MAPSRYNIRLKIRQLPIDSDDSR 215

  Fly   145 EAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQ 209
            ..:::|..|..|| :|.|.|.|...|                 :..:|.||..:.|         
Human   216 PLLKEMKRGREFR-IIFDCSHTMAAQ-----------------ILKQAMAMGMMTE--------- 253

  Fly   210 RPLEWHFVF-------LDTRDRVFKYRRQAELCTRFTL----NPR--AICRSMPMPDLYCG---- 257
               .:||:|       ||..    .||......|.|.:    ||.  ||.....|..|...    
Human   254 ---YYHFIFTTLDLYALDLE----PYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSE 311

  Fly   258 ----SGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHW 318
                .|..|..|.||.....:::.              |...|....|:.........|.....:
Human   312 SGLLDGVMMTDAALLYDAVHIVSV--------------CYQRAPQMTVNSLQCHRHKAWRFGGRF 362

  Fly   319 SNFLAYAPPLPHIQDQFQSPVPGLT--FAVNISAG--------YYSSEHEAKTDLAAWS------ 367
            .||:..|        |::    |||  ...|.::|        ..|.:.:....:..||      
Human   363 MNFIKEA--------QWE----GLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLN 415

  Fly   368 --SVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLS 430
              .|.:.|..|.|.|...|...:.|....|:...|:.:      |...|...:||||||.:..|:
Human   416 ITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSD------RTLYGNDRFEGYCIDLLKELA 474

  Fly   431 QKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQT 495
            ..|.|.:||...|.|..|..::.|:|:|:|.:|:..:.|.|:|.|.:...||:.|||..|:. ..
Human   475 HILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFM-TL 538

  Fly   496 GISIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC- 558
            |:||..||| ....|:|.|:..|..::|:.::.|.:|.:.:::.:.::|||...:   |:|  | 
Human   539 GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYD---AHP--CN 598

  Fly   559 -------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616
                   ..|||..||||.:.|...||....|||:|.|::...:|.|.:::::::||||||||||
Human   599 PGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTV 663

  Fly   617 ERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWD 681
            |||::|:.|.:.||:|::|.|..|||..|..:|...|.:  |..:||                  
Human   664 ERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKIS--TFEKMW------------------ 708

  Fly   682 YPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFA 746
                        |..||:|.|..|.....:.....||||.:.:|..|:|...||||||::|.:..
Human   709 ------------AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLID 761

  Fly   747 EQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE--GITLESLGG 809
            .:.|.:....||...|:::.|||:||::.....:|.|:|..|   .||..|::|  .:.::.:||
Human   762 SKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGS---GCPEEENKEASALGIQKIGG 823

  Fly   810 VFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHI 874
            :||....||||:::....|.:|           ::|...:.......|:.|.....|.|.|.   
Human   824 IFIVLAAGLVLSVLVAVGEFVY-----------KLRKTAEREQRSFCSTVADEIRFSLTCQR--- 874

  Fly   875 PVLEAEEKPAKVSPPPSFET------ATFRGKKLPAR 905
               ..:.||   .||...:|      .||..::||.:
Human   875 ---RVKHKP---QPPMMVKTDAVINMHTFNDRRLPGK 905

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir8aNP_727328.1 PBP2_iGluR_putative 383..786 CDD:270435 131/411 (32%)
Lig_chan 520..818 CDD:278489 96/307 (31%)
GRIK3NP_000822.2 PBP1_iGluR_Kainate_GluR5_7 34..417 CDD:107388 62/325 (19%)
ANF_receptor 55..398 CDD:279440 60/306 (20%)
PBP2_iGluR_Kainate_GluR7 433..801 CDD:270441 131/411 (32%)
Lig_chan 564..832 CDD:278489 96/307 (31%)
Glutamate binding. /evidence=ECO:0000250 690..692 0/1 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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