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Protein Alignment Ir8a and GRIK2

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	1025	Identity:	242/1025 - (23%)
Similarity:	406/1025 - (39%)	Gaps:	257/1025 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVLLL----------ALRFA-----------GSEVLKITFWIEPVQRAEFDTDIAMVLKELDAL 48
            ||:.||          .|||.           |:|.|...|.:..:.|..
Human    19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNR--------------- 68

  Fly    49 RLDVKVDDTTLTLTRSEDGL-----DMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRS----LG 104
               ..:.:||||....:..|     ..::.|:.|| :|.:|:...::|   ...|.|:|    ||
Human    69 ---TLLPNTTLTYDTQKINLYDSFEASKKACDQLS-LGVAAIFGPSHS---SSANAVQSICNALG 126

  Fly   105 IGYVRL-------ERIMRPFLDMFGDFMRQKRA----------NNVAMVF------MNARDAVEA 146
            :.:::.       :.....::.::.||....||          ..|.:|:      :..::.::|
Human   127 VPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKA 191

  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAM-NGIFEKVQKADLFQR 210
            ..:..:....|.|..|.....|      .::.::....:..:|..:..| .||.::.....:...
Human   192 PSRYNLRLKIRQLPADTKDAKP------LLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTE 250

  Fly   211 PLEWHFVF-------LDTRDRVFKYRRQAELCTRF----TLNPRAI----------CRSMPMPDL 254
              .:|::|       ||    |..||......|.|    |.|.:..          .::.|.||.
Human   251 --YYHYIFTTLDLFALD----VEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDS 309

  Fly   255 YCGSGF-TMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCN-------ATASSSEVSDPLEKDDYN 311
            ....|| |...|::.:.:..:..|.|..|...::..| ||       .|...|.:.:
Human   310 GLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ-CNRHKPWRFGTRFMSLIKE-------- 365

  Fly   312 WLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLT----------FAVNISAGYYSSEHEAKTDLAAW 366
                .||.                     |||          ...:......|.:.|....:..|
Human   366 ----AHWE---------------------GLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTW 405

  Fly   367 SSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCI 423
            .....:.:        .|.|.|.:.|...:.|....|:...::.:      :...|...:|||||
Human   406 DPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSD------KPLYGNDRFEGYCI 464

  Fly   424 DFIIRLSQKLNFEFEIVAPEVGHMGELNEL-GEWDGVVGDLVRGETDFAIAALKMYSEREEVIDF 487
            |.:..||..|.|.:||...|.|..|..::. |:|:|:|.:|:..:.|.|:|.|.:...||:||||
Human   465 DLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDF 529

  Fly   488 LPPYYEQTGISIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNR 551
            ..|:. ..||||..||| .....:|.|:..|..::|:.|:.|.:|.:.:::.:.::|||...|
Human   530 SKPFM-TLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYN-- 591

  Fly   552 QAYPYAC--------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTA 608
               |:.|        ..|||..||||.:.:...||....|||:|.|::...:|.|.:::::::||
Human   592 ---PHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 653

  Fly   609 NLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKD 673
            |||||||||||::|:.|.:.||:|::|.|..|:|..|..:|...|.:  |..:||   |..:|:
Human   654 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIS--TYDKMW---AFMSSR- 712

  Fly   674 FKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNL 738
                                  ..|..|...:||...|   ..:||||:.:|..|::...|||||
Human   713 ----------------------RQSVLVKSNEEGIQRV---LTSDYAFLMESTTIEFVTQRNCNL 752

  Fly   739 TEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGIT 803
            |::|.:...:.|.|....||...|:::.|||:||::.....:|.|:|..:   .||..|.:|...
Human   753 TQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN---GCPEEESKEASA 814

  Fly   804 L--ESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE--------ITQVRPVNDSSGSGGNSS 858
            |  :::||:||....||||::.....|.||..||...||        :.::|
Human   815 LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELR------------- 866

  Fly   859 TAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARITL 908
                .:....::..|.|     :.|..|.........||..::||.:.|:
Human   867 ----MSLKCQRRLKHKP-----QAPVIVKTEEVINMHTFNDRRLPGKETM 907

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.