DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir8a and GRIK1

DIOPT Version :9

Sequence 1:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_001317923.1 Gene:GRIK1 / 2897 HGNCID:4579 Length:949 Species:Homo sapiens


Alignment Length:809 Identity:212/809 - (26%)
Similarity:346/809 - (42%) Gaps:152/809 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 AVIDLT-YSHWEEGYNLVRSLGIGYVRLERIMR-PFLDMFGDFMRQKRANNVAMVFMNARDAVEA 146
            |::||. |.:|:. ..:|.....|.:||:.::: |........:||..:.|        :||...
Human   160 AILDLVLYYNWKT-VTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGN--------KDAKPL 215

  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRP 211
            :::|..|..| .:|.|.|. :.....|::|..:.....|...|            ....|||...
Human   216 LKEMKKGKEF-YVIFDCSH-ETAAEILKQILFMGMMTEYYHYF------------FTTLDLFALD 266

  Fly   212 LEWHFVFLDTRDRVFKYRRQAELCTRFTL----NPRAI----------CRSMPMPDLYCGSG-FT 261
            ||             .||......|.|.|    ||...          .::.|.|:.....| .|
Human   267 LE-------------LYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMT 318

  Fly   262 MQRAMLLNVLRSLINAAQVSPGYPLAI--YQDCNATASSSEV--SDP--LEKDDYNWLDMVHWSN 320
            .:.|::.:.:            |.:||  ::....|.||.:.  ..|  |.....|.:....|..
Human   319 TEAALMYDAV------------YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDG 371

  Fly   321 FLAYAPPLPHI--------QDQFQSPVPGLTFAVNISAGYYSSEHEAKT--DLAAWSSVGEMRLL 375
            ...      ||        :..|...:..|.......|....|:|..|.  .:..|:|...:.:.
Human   372 LTG------HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMT 430

  Fly   376 --------NETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQK 432
                    |.|.|.|.|...:.|....|:...|:.:      :...|...:||||:|.:..||..
Human   431 DSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD------KPLYGNDRFEGYCLDLLKELSNI 489

  Fly   433 LNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGI 497
            |.|.:::.....|..|..|:.|||:|:|.:|:....|.|:|.|.:...||:||||..|:. ..||
Human   490 LGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFM-TLGI 553

  Fly   498 SIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC--- 558
            ||..||| .....:|.|:..|..::|:.::.|.:|.:.:::.:.:::||...|     |:.|   
Human   554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYN-----PHPCNPD 613

  Fly   559 -----REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVER 618
                 ..|||..||||.:.:...||....|||:|.|::...:|.|.:::::::||||||||||||
Human   614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 678

  Fly   619 MQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYP 683
            |::|:.|.:.||:|::|.|..|:|..|..:|...|.:  |..:||   |..:|:           
Human   679 MESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIS--TYEKMW---AFMSSR----------- 727

  Fly   684 IKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQ 748
                        ..:..|.::.||...|   ...|||.:.:|..|:|...||||||::|.:...:
Human   728 ------------QQTALVRNSDEGIQRV---LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSK 777

  Fly   749 PYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGITL--ESLGGVF 811
            .|.|....||...|:::.|||:||::.....:|.|:|..:   .||..:::|...|  |::||:|
Human   778 GYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN---GCPEEDNKEASALGVENIGGIF 839

  Fly   812 IATLFGLVLAMMTLGMEVLYYKKKQNALE 840
            |....||||::.....|.:|..:|.|.:|
Human   840 IVLAAGLVLSVFVAIGEFIYKSRKNNDIE 868

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir8aNP_727328.1 PBP2_iGluR_putative 383..786 CDD:270435 127/411 (31%)
Lig_chan 520..818 CDD:278489 93/307 (30%)
GRIK1NP_001317923.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:324556 62/323 (19%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:328725 127/411 (31%)
Glutamate binding. /evidence=ECO:0000250 531..533 0/1 (0%)