DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir8a and GRIA4

DIOPT Version :9

Sequence 1:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_000820.4 Gene:GRIA4 / 2893 HGNCID:4574 Length:902 Species:Homo sapiens


Alignment Length:877 Identity:206/877 - (23%)
Similarity:351/877 - (40%) Gaps:227/877 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 DTDIAMVLKELDALR-----LDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWE 94
            |.....:|:|||..:     :|.:::             .:|...|.:.:||...          
Human   191 DVSYRQLLEELDRRQEKKFVIDCEIE-------------RLQNILEQIVSVGKHV---------- 232

  Fly    95 EGYN-LVRSLGIGYVRLERIMRPFLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGY 154
            :||: ::.:||...:.|||.:....::.|    ||       |..|| :...|..:.:.|.  .|
Human   233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDF-------NTPMV-IKLMDRWKKLDQR--EY 287

  Fly   155 PFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFL 219
            |       .|:|.|         ....|.||..:...|.....:  :.||.|:.:          
Human   288 P-------GSETPP---------KYTSALTYDGVLVMAETFRSL--RRQKIDISR---------- 324

  Fly   220 DTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGY 284
                     |..|..|   ..||.|     |.     |.|..|:|.:....::.|....|     
Human   325 ---------RGNAGDC---LANPAA-----PW-----GQGIDMERTLKQVRIQGLTGNVQ----- 362

  Fly   285 PLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNIS 349
                                                |..|...:.:..|.|:....|..     .
Human   363 ------------------------------------FDHYGRRVNYTMDVFELKSTGPR-----K 386

  Fly   350 AGYYSSEHEAKTDLAAWSSVGEMRLL-------NETISPARRFFRIGTAESIPWSYLRREEGTGE 407
            .||             |:.:.::.|:       |:|.:...|...:.|....|:...::.....|
Human   387 VGY-------------WNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFE 438

  Fly   408 LIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFA 471
                  |...:||||:|....:::.:..:::|.....|..|..: :...|:|:||:||.|:.:.|
Human   439 ------GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIA 497

  Fly   472 IAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIM 535
            ||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::
Human   498 IAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 561

  Fly   536 IWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLV 592
            ::.:.::|||        ..:......|  ..||.:..|.||:|.:|..||...:|:::|||::.
Human   562 LFLVSRFSPYEWHTEEPEDGKEGPSDQP--PNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 624

  Fly   593 AAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAED 657
            ..:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..:....|.::|...|.|  
Human   625 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA-- 687

  Fly   658 TLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADY 719
             :|.                ::|.|            :.|::|   .....||.|.| ......:
Human   688 -VYE----------------KMWTY------------MRSAEPSVFTRTTAEGVARV-RKSKGKF 722

  Fly   720 AFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAK 783
            ||:.:|...:| |..:.|:..:||.....:.|.||..:||.|...::.|:|:|.:....::||.|
Human   723 AFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK 787

  Fly   784 YWNQSNL--PNCPLSEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQ-NALEIT-- 842
            :|.....  |....|:|: ..::|.::.|||...:.||.|||:...:|..|..:.: ..:::|  
Human   788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFS 852

  Fly   843 -QVR-----PVNDSSGSGGNSSTAP-PTATST 867
             .:|     .:..|.|..|...|.. |.|..|
Human   853 EAIRNKARLSITGSVGENGRVLTPDCPKAVHT 884

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir8aNP_727328.1 PBP2_iGluR_putative 383..786 CDD:270435 121/416 (29%)
Lig_chan 520..818 CDD:278489 87/312 (28%)
GRIA4NP_000820.4 PBP1_iGluR_AMPA_GluR4 28..398 CDD:107383 58/348 (17%)
PBP2_iGluR_AMPA_GluR4 414..795 CDD:270445 122/421 (29%)
Glutamate binding. /evidence=ECO:0000250 500..502 0/1 (0%)