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Protein Alignment Ir8a and GRIA3

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	853	Identity:	211/853 - (24%)
Similarity:	364/853 - (42%)	Gaps:	199/853 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 MRP-----FLDMFGDFMRQK--------RANNVAMVFMNARDAVEAMQQML---VG-----YPFR 157
            |||     .|.:.|.:..:|        |..::....|.|  ||:...|:.   ||     ..||
Human   141 MRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA--AVQNNWQVTARSVGNIKDVQEFR 203

  Fly   158 TLIMDASQTDPGQHFL----ERIRSL--------RPAPTYIALFARAAAMNGIFEKVQKADL--- 207
            .:|.:..:....::.:    |||.::        :.:..|..:.|.....:.:.|:|.....
Human   204 RIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANIT 268

  Fly   208 -FQ-----RPLEWHF----VFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTM 262
             ||     .|:...|    |.||.|:  |...:.|.|.....|...||        |.....|..
Human   269 GFQIVNNENPMVQQFIQRWVRLDERE--FPEAKNAPLKYTSALTHDAI--------LVIAEAFRY 323

  Fly   263 QRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPP 327
            .|...::|.|      :.|.|       ||.|..:                  |.||..:.....
Human   324 LRRQRVDVSR------RGSAG-------DCLANPA------------------VPWSQGIDIERA 357

  Fly   328 LPHIQDQFQSPVPGLT-------------FAVNI---------SAGYYSSEHEAKTDLAAWSSVG 370
            |..:|      |.|:|             :.:::         .|||: :|:|      .:....
Human   358 LKMVQ------VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYW-NEYE------RFVPFS 409

  Fly   371 EMRLLNETISPARRFFRIGTAESIPW-SYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLN 434
            :.::.|::.|...|...:.|....|: .|.:..|       ...|...:||||:|....:::.:.
Human   410 DQQISNDSASSENRTIVVTTILESPYVMYKKNHE-------QLEGNERYEGYCVDLAYEIAKHVR 467

  Fly   435 FEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGIS 498
            .::::.....|..|..: |...|:|:||:||.|..|.|:|.|.:...|||||||..|:. ..|||
Human   468 IKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFM-SLGIS 531

  Fly   499 IAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYS---SRNNR-----QAY 554
            |.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::::.:.::|||.   ..||.     |:.
Human   532 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSP 596

  Fly   555 PYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERM 619
            |....||.:..|.||:|.:|..||...:|:::|||::...:|.|.:::::::|||||||||||||
Human   597 PDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 661

  Fly   620 QTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPI 684
            .:|::|.|.||:|:.|.|..:....|.::|...|.|   :|.                ::|.|
Human   662 VSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA---VYE----------------KMWSY-- 705

  Fly   685 KEQYGHILLAINSSQPVADAK---EGFANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVF 745
                      :.|::|....|   :|.|.| ......:||:.:|...:| |..:.|:..:||...
Human   706 ----------MKSAEPSVFTKTTADGVARV-RKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNL 759

  Fly   746 AEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPL----SEDQ-EGITLE 805
            ..:.|.||..:||.|.:.::.|:|:|.:....::||.|:|....  .|..    |:|: ..::|.
Human   760 DSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKG--ECGSGGGDSKDKTSALSLS 822

  Fly   806 SLGGVFIATLFGLVLAMMTLGMEVLYYKKKQN-ALEITQVRPVNDSSGSGGNSSTAPPTAT---S 866
            ::.|||...:.||.||||...:|..|..:.:: .:::|:         :..|...||.|.|   :
Human   823 NVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTK---------NTQNFKPAPATNTQNYA 878

  Fly   867 TTKQAWHI 874
            |.::.:::
Human   879 TYREGYNV 886

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.