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Protein Alignment Ir8a and GRIA2

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	569	Identity:	153/569 - (26%)
Similarity:	274/569 - (48%)	Gaps:	88/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 LTFAVNISAGYYSSEHEAKTD----LAAWSSVGEMRLL-------NETISPARRFFRIGTAESIP 395
            :.:.:||.        |.||:    :..||.|.:|.:.       |:|.....:...:.|....|
Human   369 INYTINIM--------ELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESP 425

  Fly   396 WSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGV 459
            :..:::..   |::   .|...:||||:|....:::...|::::.....|..|..: :...|:|:
Human   426 YVMMKKNH---EML---EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGM 484

  Fly   460 VGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWL 523
            ||:||.|:.|.|||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:
Human   485 VGELVYGKADIAIAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548

  Fly   524 SIVAALVGTAIMIWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGG 580
            .||.|.:|.:::::.:.::|||        ..|..:.:  .:..||.:..|.||:|.:|..||..
Human   549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS--ESTNEFGIFNSLWFSLGAFMQQGCD 611

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDT 645
            .:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.|::|:.|.|..:....|
Human   612 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGST 676

  Fly   646 HQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEG 707
            .::|...|.|.                 |.|  :|.|            :.|::|   |....||
Human   677 KEFFRRSKIAV-----------------FDK--MWTY------------MRSAEPSVFVRTTAEG 710

  Fly   708 FANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771
            .|.| ......||::.:|...:| |..:.|:..:||.....:.|.:|..:||.|...::.|:|:|
Human   711 VARV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKL 774

  Fly   772 QKDRFFEELKAKYW---NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYK 833
            .:....::||.|:|   .:....:....|....::|.::.|||...:.||.|||:...:| ..||
Human   775 SEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE-FCYK 838

  Fly   834 KKQNALEI---TQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEA 879
            .:..|..:   ...:.:|.||.....:       .:|.|:.:::..:|:
Human   839 SRAEAKRMKVAKNAQNINPSSSQNSQN-------FATYKEGYNVYGIES 880

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.