back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and Grin2a

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	953	Identity:	198/953 - (20%)
Similarity:	345/953 - (36%)	Gaps:	269/953 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 WIEPVQRAEFD-----TDIAMVL-----------------KELDALRLDVKVDDTTLTLTRSEDG 67
            |.:|.|.|..:     .:||::|                 ::...|.|||.|  ..|.:.|::..
  Rat    18 WRDPAQNAAAEKGPPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLDVNV--VALLMNRTDPK 80

  Fly    68 LDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGD--FMRQKRA 130
            ..:...|:::|  ||.                :..|..|....:..:...||....  |:.....
  Rat    81 SLITHVCDLMS--GAR----------------IHGLVFGDDTDQEAVAQMLDFISSQTFIPILGI 127

  Fly   131 NNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAM 195
            :..|.:.|..:|......|.......:..:|.....|...|....:.::.|.......|.:....
  Rat   128 HGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVD 192

  Fly   196 NGIFEKVQKADLFQRPLEWHFVFLDTRDRVFK-YRRQAELCTRFTLNPRAICRSMPMPDLYCGSG 259
            |..             :.|....:.|.|..|: .:.|.:|        :.|..|:.:  |||...
  Rat   193 NSF-------------VGWDMQNVITLDTSFEDAKTQVQL--------KKIHSSVIL--LYCSKD 234

  Fly   260 FTMQRAMLLNVLRSL----------------INAAQVSPGYPLAI----YQDCN----------- 293
               :..::|:..|||                .|...:...:|..:    |.|.:
  Rat   235 ---EAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGL 296

  Fly   294 ---ATASSSEVSDPLEKDDYNWLDMVHWSNF-LAYAPPLP-HIQDQFQSPV----PGLTFAVNIS 349
               .||:||    .|||  ::::.....|.: .|..|..| |...||...|    ..|:|.   .
  Rat   297 GILTTAASS----MLEK--FSYIPEAKASCYGQAEKPETPLHTLHQFMVNVTWDGKDLSFT---E 352

  Fly   350 AGY----------YSSEHEAKTDLAAWSSVGEMRLLNETIS----------------PARRFFRI 388
            .||          .:.:.|       |..||:..  |:|:|                |......|
  Rat   353 EGYQVHPRLVVIVLNKDRE-------WEKVGKWE--NQTLSLRHAVWPRYKSFSDCEPDDNHLSI 408

  Fly   389 GTAESIPW---------------------SYLRREEGTGELIRDRSGLPI---WEGYCIDFIIRL 429
            .|.|..|:                     .:::....|.|      |:.:   .:|:|||.:.:|
  Rat   409 VTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNE------GMNVKKCCKGFCIDILKKL 467

  Fly   430 SQKLNFEFEIVAPEVG-HMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYE 493
            |:.:.|.:::.....| |..::|.:  |:|::|::|......|:.:|.:..||.||:||..|:.|
  Rat   468 SRTVKFTYDLYLVTNGKHGKKVNNV--WNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVE 530

  Fly   494 QTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWFMDKYSPYSSRNN--RQAYP 555
             ||||:.:.:.....|...|:......|| :..|..|:.:||.::..:.:||.....|  :...|
  Rat   531 -TGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAP 594

  Fly   556 YACREFTLRESFW----FALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616
            :. ..||:.::.|    ....:..|.   :.||..:.:::|:.:..|.|:.||::|||||||:..
  Rat   595 HG-PSFTIGKAIWLLWGLVFNNSVPV---QNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQ 655

  Fly   617 ERMQTPVQSLEQLARQSRINYT------VVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFK 675
            |.....|..|.....|...:|:      .|.:..|.:...|
  Rat   656 EEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRN------------------------ 696

  Fly   676 KFRIWDYPIKEQYGHILLAINSSQPVADA----KEGFANVDAHENADYAFIHDSAEIKYEITRN- 735
                 :||...||    :...:.:.|.||    |.|  .:|       |||:|:|.:.|:..|:
  Rat   697 -----NYPYMHQY----MTRFNQRGVEDALVSLKTG--KLD-------AFIYDAAVLNYKAGRDE 743

  Fly   736 -CNLTEVGE--VFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYW------NQSNLP 791
             |.|..:|.  :||...|.:|:|:||....::..|:|:...|...|||:. .|      |:.|
  Rat   744 GCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELET-LWLTGICHNEKN-- 805

  Fly   792 NCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKK 834
              .:...|  :.::::.|||......:.|:::|...|.|:|.|
  Rat   806 --EVMSSQ--LDIDNMAGVFYMLAAAMALSLITFIWEHLFYWK 844

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.