DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and Grik5

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	1118	Identity:	252/1118 - (22%)
Similarity:	413/1118 - (36%)	Gaps:	344/1118 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTT---------LTL 61
            |:|||.:.||...                       .:.|.:||:...:||.|         |.|
  Rat     5 LLLLLIVAFANPS-----------------------CQVLSSLRMAAILDDQTVCGRGERLALAL 46

  Fly    62 TRSE---------------DGLDMQR---------FCEIL------------STVGASAV----- 85
            .|.:               |..::||         .|:||            |...||.|
  Rat    47 AREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICG 111

  Fly    86 ---------------------------------IDLTYSHWEEGYN-----LVRSLGIGYVRLER 112
                                             :.|..|...:.:|     |:.:.....:|||.
  Rat   112 EKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEE 176

  Fly   113 IMRPFL--------DMFGD------FMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDA 163
            ::|.||        .|..|      .:::.|.:.|:.:.::|..::..:           ::..|
  Rat   177 LVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHL-----------VLRKA 230

  Fly   164 SQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFE---KVQKADLF--QRPLEWHFVFLDTRD 223
            |:......|.:.|.:....|        ...::||.|   .:....:|  ..|....||    |.
  Rat   231 SELGMTSAFYKYILTTMDFP--------ILHLDGIVEDSSNILGFSMFNTSHPFYPEFV----RS 283

  Fly   224 RVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAI 288
            ....:|...|..|            .|.|.|.....|.... ::::.:|.| |.:|.....|||
  Rat   284 LNMSWRENCEAST------------YPGPALSAALMFDAVH-VVVSAVREL-NRSQEIGVKPLA- 333

  Fly   289 YQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYY 353
                   .:|:.:. |......|:|.||.:.....        :.:|.|......:.:.|    .
  Rat   334 -------CTSANIW-PHGTSLMNYLRMVEYDGLTG--------RVEFNSKGQRTNYTLRI----L 378

  Fly   354 SSEHEAKTDLAAWSSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIR 410
            ....:...::..|.|...:.:        |::|:  |.:...:.|....|  |:.|......|
  Rat   379 EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTL--ANKTLVVTTILENP--YVMRRPNFQAL-- 437

  Fly   411 DRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLV-RGETDFAIAA 474
              ||...:||:|:|.:..|::.|.|.:.:...|.|..|.....|.|.|:||:|: |.:.|.|:||
  Rat   438 --SGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500

  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWF 538
            ..:.:|||:||||..|:. ..||||..|..: |:...|.|:......|||.::.|.:..:.:::.
  Rat   501 FTITAEREKVIDFSKPFM-TLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFL 564

  Fly   539 MDKYSPYSSRNNRQAYPYAC---------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAA 594
            ..:.|||...|     |:.|         .::||..|.||.:..|..||....|:|:|.|.:...
  Rat   565 AARLSPYEWYN-----PHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGV 624

  Fly   595 YWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTL 659
            :|.|.:::::::||||||||||:||:.||:|.:.||.|:.|.|..:....|..:|.|.::  .|.
  Rat   625 WWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRY--QTY 687

  Fly   660 YRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAF 721
            .|||..:                             .|.||   |...:||.|.|   .|:.|||
  Rat   688 QRMWNYM-----------------------------QSKQPSVFVKSTEEGIARV---LNSRYAF 720

  Fly   722 IHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWN 786
            :.:|...:|....|||||::|.:...:.|.:.:..||...||::.|||:||::...|.||.|:|.
  Rat   721 LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE 785

  Fly   787 QSNLPNCPLSEDQ--EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKK----------QNAL 839
            ..   .||..||.  :|:.:|::||:|:..:.||::|:....||.::..::          |..|
  Rat   786 GG---RCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEML 847

  Fly   840 E--------------------------ITQVRPVND---------SSGSGGNSST---------- 859
            :                          :..:|.|.:         |:|:||::..
  Rat   848 QELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDD 912

  Fly   860 -APP-----------TATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARITLGDGK 912
             .||           |.....::...|..|.|....|    ||       ||...||..|   ..
  Rat   913 PGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGA----PP-------RGLGTPAEAT---SP 963

  Fly   913 FKPRHGLYARRNL 925
            .:||.|....|.|
  Rat   964 PRPRPGPTGPREL 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	129/416 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	95/311 (31%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	71/435 (16%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	129/416 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810