Protein Alignment Ir8a and Grik4

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_036704.1
• Gene: Grik4 / 24406
• RGDID: 2734
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 1017
• Identity: 242/1017 - (23%)
• Similarity: 405/1017 - (39%)
• Gaps: 252/1017 - (24%)

  Fly     3 LPLLVLLLA-----LRFAG----------SEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDV 52
            ||..:|::|     ||.|.          .|.|.||.....:.||.         :.|...:::|
  Rat    11 LPAWLLMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAP---------ERLGKAKVEV 66

  Fly    53 KVDDTTLTLTRSEDGLDMQRFCEIL-----------STVGASAVIDLTYSHWEEGYNLVRSLGIG 106
            .:    ..|.|..:....:..|:||           |:..:|::|.          |:.....:.
  Rat    67 DI----FELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIIS----------NICGEKEVP 117

  Fly   107 YVRL--ERIMRPFLDMFGDFMRQKRANNVAMV------FMNARDAV-------------EAMQQM 150
            :.::  |..:|..|..|..........::::.      |.|...|.             :.::|.
  Rat   118 HFKVAPEEFVRFQLQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQF 182

  Fly   151 LVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWH 215
            |:.....::.|.....|| ...|:.||..:.|.  |.:.|.|:..:.|..|.  |:|......:.
  Rat   183 LISKDTLSVRMLDDTRDP-TPLLKEIRDDKTAT--IIIHANASMSHTILLKA--AELGMVSAYYT 242

  Fly   216 FVFLDTR-----------DRV----FKYRRQA-----ELCTRFTLNPRAICRSMPMPDLYCGSGF 260
            ::|.:..           |||    |....|:     |.......:.:..|..:|.      :|.
  Rat   243 YIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPF------TGP 301

  Fly   261 TMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVS-DPLEKDD----------YNWLD 314
            .:..|:|.:.:.:::.|.           |:.|   .|.|:. .||....          .|:|.
  Rat   302 ALSSALLFDAVYAVVTAV-----------QELN---RSQEIGVKPLSCGSAQIWQHGTSLMNYLR 352

  Fly   315 MVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNI---------SAGYYSSEHEAKTDLAAWSSVG 370
            ||.......      ||  :|.|......:|:.|         ..|.:........|...::|..
  Rat   353 MVELEGLTG------HI--EFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSRLYASNI 409

  Fly   371 EMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNF 435
            ...|.|.|:.       :.|....|:..|:...      :|..|...:||:|:|.:..|::.|.|
  Rat   410 SDSLFNTTLV-------VTTILENPYLMLKGNH------QDMEGNDRYEGFCVDMLKELAEILRF 461

  Fly   436 EFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIA 500
            .::|.....|..|.....|.|.|:||:|:..:.|.|:|.|.:.:|||:||||..|:. ..||||.
  Rat   462 NYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFM-TLGISIL 525

  Fly   501 IRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC------ 558
            .|..: ||...|.|:......|||.::.|.:..:.:::.:.:.:||...:     |:.|
  Rat   526 YRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYS-----PHPCAQGRCN 585

  Fly   559 ---REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQ 620
               .:::|..|.||.:..|..||...||:|:|.|.:...:|.|.:::::::||||||||||:||:
  Rat   586 LLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRME 650

  Fly   621 TPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIK 685
            .|::|::.||.|:.|.|..:....:..:|.|.::  .|..|||..:
  Rat   651 VPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRY--QTYQRMWNYM------------------- 694

  Fly   686 EQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAE 747
                      .|.||   |...:||.|.|   .|::|||:.:|...:|...||||||::|.:...
  Rat   695 ----------YSKQPSVFVKSTEEGIARV---LNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDT 746

  Fly   748 QPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQ--EGITLESLGGV 810
            :.|.:.:..||...||...|||:||::...|.||.|:|...   .||..||.  :|:.:|::||:
  Rat   747 KGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGG---KCPKEEDHRAKGLGMENIGGI 808

  Fly   811 FIATLFGLVLAMMTLGMEVLYYKKKQNALEI-------TQVRPV---NDS-----SGSGGNSSTA 860
            |:..:.||::|:....:|.|:..:...|.|:       |::|.:   .|:     ..|||    .
  Rat   809 FVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMMTELRSIILCQDNIHPRRRRSGG----L 869

  Fly   861 PPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKL 902
            ||..          |||| |.:|.        .|||....||
  Rat   870 PPQP----------PVLE-ERRPR--------GTATLSNGKL 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	124/415 (30%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	73/433 (17%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	126/422 (30%)
		QRL_CxxC_CxxC	863..927	CDD:469521	16/53 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956