DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir8a and Grin3a

DIOPT Version :9

Sequence 1:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster
Sequence 2:NP_001263284.1 Gene:Grin3a / 242443 MGIID:1933206 Length:1135 Species:Mus musculus


Alignment Length:890 Identity:194/890 - (21%)
Similarity:334/890 - (37%) Gaps:239/890 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 LKELDALR--LDVKVDDTTLTLTR------SEDGLDMQRFCE-ILSTVGASAVIDLTYSHW---- 93
            :.|||.:.  |.:.|    |::.|      |::.|.:|...| .||:.....|..||.::|    
Mouse   206 MMELDLVSSVLHIPV----LSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFS 266

  Fly    94 ----EEGYNLVRSLGI----GYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQM 150
                :|.:|:...|.:    ....||.|:                 |:.....:.:|.:..:|..
Mouse   267 LLLCQEDWNITDFLLLTENNSKFHLESII-----------------NITANLSSTKDLLSFLQVQ 314

  Fly   151 LVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWH 215
                                  ||.||:  ..||.:.......::..|||...:..|  .|.:.|
Mouse   315 ----------------------LENIRN--STPTMVMFGCDMGSIRQIFEMSTQFGL--SPPDLH 353

  Fly   216 FVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGS------GFTMQRAMLLNVLRSL 274
            :|..|:::       ..||.|          ..:|:..:..|.      .:.:|.||.| |.|::
Mouse   354 WVLGDSQN-------VEELRT----------EGLPLGLIAHGKTTQSVFEYYVQDAMEL-VARAV 400

  Fly   275 INAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPV 339
            ..|..:.|  .||:..   :|.:..:|...      |.....:.|.|||            .:..
Mouse   401 ATATMIQP--ELALLP---STMNCMDVKTT------NLTSGQYLSRFLA------------NTTF 442

  Fly   340 PGLTFAVNISAG-YYSSEHE--------------AKTDLAAWSSVGEMRLLNETISP--ARR--- 384
            .||:.::.:... ..|||:.              ..|.|.:|.  |...:::..|.|  |:|   
Mouse   443 RGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQ--GGRIVMDSGIWPEQAQRHKT 505

  Fly   385 --------FFRIGTAESIPWSYLRR--EEG---TGELIRD-------------------RSGLPI 417
                    ..|:.|....|:.:.|.  :||   .|:|..|                   ...:||
Mouse   506 HFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPI 570

  Fly   418 -----WEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKM 477
                 ..|||||.:.:|::.:||:|::.....|..|.... |.|.|:||||:.|..:.|:.:..:
Mouse   571 KFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKN-GHWTGLVGDLLSGTANMAVTSFSI 634

  Fly   478 YSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKY 542
            .:.|.:||||..|:: .|.:.|.:|.......:..||..|...:||.|..||..|||.:...:..
Mouse   635 NTARSQVIDFTSPFF-STSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWK 698

  Fly   543 SPY----SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLML 603
            ||:    ..||..:.:     .|:...:..:||. |......:.||..:||.|:..:.:|.:..|
Mouse   699 SPFGMTPKGRNRNKVF-----SFSSALNVCYALL-FGRTAAIKPPKCWTGRFLMNLWAIFCMFCL 757

  Fly   604 ATFTANLAAFLTVERMQTPVQSLE--QLARQSR-INYTVVKDSDTHQYFVNMKFAEDTLYRMWKE 665
            :|:||||||.:..|::...:..:.  :|...|: ..:..|::|....| |...|.|...|     
Mouse   758 STYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY-VRQSFPEMHEY----- 816

  Fly   666 LALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKY 730
                    .:::.:...|...||       ..:.|              |..| |||.|.|.:.|
Mouse   817 --------MRRYNVPATPDGVQY-------LKNDP--------------EKLD-AFIMDKALLDY 851

  Fly   731 EIT--RNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNC 793
            |::  .:|.|..||:.||.:.|.:.:...|.|...:|..|.:.:...|.:.|..|::..     .
Mouse   852 EVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKV-----V 911

  Fly   794 PLSEDQEGIT------LESLGGVFIATLFGLVLAMM-TLGMEVLY 831
            |..:....:|      ::...|:|:....|..|::: |:|..::|
Mouse   912 PCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVY 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir8aNP_727328.1 PBP2_iGluR_putative 383..786 CDD:270435 111/451 (25%)
Lig_chan 520..818 CDD:278489 71/312 (23%)
Grin3aNP_001263284.1 PBP1_iGluR_NMDA_NR3 30..497 CDD:107372 72/380 (19%)
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 110/439 (25%)
Lig_chan 676..942 CDD:278489 71/312 (23%)
PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7 951..987 2/6 (33%)
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1082..1115
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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