DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and glr-7

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	926	Identity:	287/926 - (30%)
Similarity:	438/926 - (47%)	Gaps:	170/926 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LDALRLDVKVDDTTLTLTRSE--DGLDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGY 107
            :|..|:||      ::|.|.:  |..|:...|:  ..|..|.||.:..|:  :..:||..|
Worm     4 VDKYRVDV------ISLERYDFNDSSDINSLCD--QMVNVSFVISVCRSN--DSISLVAEL---- 54

  Fly   108 VRLERIMRPFLDM-FGDFMRQKRANNV--------------AMVFMNARDAVEA----MQQMLVG 153
            .|:.::....:|: :..........:|              .:||.|....:.|    .....|.
Worm    55 ARISQVPTIQVDLNYWSLPLNFNGTSVPTISSPSYTTMVLSTLVFQNVITDIFADLNITPNSTVL 119

  Fly   154 Y-----PFRTLIMDASQTDPGQHFL---ERIRSLRPAPTYIALFARAAAMNGIF-----EKVQK- 204
            |     |..|...||....||..|:   ..:..:|...|.:    |.|::|.:.     |.|::
Worm   120 YDNMYPPDFTAWRDAFSVLPGIRFVPMETTVLRMRAQITQL----RMASINSLILVAKTENVERF 180

  Fly   205 ----ADLFQRPLEWHFVFLDTRD-RVFKYRRQAELCTRFTLNPRAICRSMPMPDL---------- 254
                ||..::.:...:|.  |:| ..||. ...|....|.|.|..:.:.|.:.||
Worm   181 TLEAADFIEQRVFNTYVL--TKDITAFKC-DSCESAFMFWLRPFPVGKLMEIRDLDDYLFRNEIG 242

  Fly   255 ----YCGSGF-TMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNAT----------ASSSEVSDP 304
                |..:|: ::..|..:||:           ||.....:..|||          ...||.:..
Worm   243 LELDYSINGWDSLNVAFYMNVM-----------GYAFETIRTMNATFDVLPTFTCQTGPSEPNIT 296

  Fly   305 LEKDDYNWLDMVH-WSNFLAYAPPLPHIQDQFQSPVPGLT-FAVNISAGYY----SSEHE---AK 360
            ....|....|..| :.|:..                .||. |..::....|    ..:||   ..
Worm   297 TTVRDIILNDPAHEYGNYTE----------------AGLNMFFQDVEVRIYKIDRDRDHEDALFN 345

  Fly   361 TDLAAWSSVGEMRLLNETISPARR---FFRIGTAESIPWSYLRREEGTGELIRDRSGLP--IWEG 420
            .::..||.:.::.::..|:....|   .||:.|....|:.             .|:|.|  .:||
Worm   346 KEVGVWSPISKLSVMYGTLQVDVRNLNIFRVVTLIQPPFV-------------QRTGDPDTPYEG 397

  Fly   421 YCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVI 485
            ||||.|..:..::||.:.|...|.|..|.:::.|.|:|::|.||.|..|.|:|.|.:.:|||..:
Worm   398 YCIDLINMIQVEVNFTYTIYEVEDGSFGTMDDNGNWNGLIGALVSGSADIALAPLSVMAERENDV 462

  Fly   486 DFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNN 550
            ||..|||:..|.:|.::|.....||||||.||...|||.||||.:.|:|::|..|::||||..||
Worm   463 DFTVPYYDLVGTTILMKKADVEYSLFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTNN 527

  Fly   551 RQAY--PYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAF 613
            ::.|  ....|:|:|:|..||.:||.||||||||||.||||::.|.:|||..:::|::|||||||
Worm   528 KERYQNDIEKRQFSLKECLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAF 592

  Fly   614 LTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNAS---KDFK 675
            |||.|::.|:.||:.||:|.:|.|..:|.|.:..||..|...|:|.|.||||::||.|   :|..
Worm   593 LTVSRLEQPISSLDDLAKQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRA 657

  Fly   676 KFRIWDYPIKEQYGHILLAINSSQ-PVADAKEGFANVDAH-----ENAD-YAFIHDSAEIKYEIT 733
            |..:||||:.:::.::...:..|: ||        |:|..     .:.| :|||.|:.||||...
Worm   658 KLAVWDYPVSDKFTNMWRYMQESKLPV--------NMDTAVDRVLNSVDGFAFIGDATEIKYAAL 714

  Fly   734 RNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQS-NLPNCPLSE 797
            .||||.:||..|:.:|||:|||.|..|.|::|.|||.|..:|..|.||.|:|..: |..:||.|.
Worm   715 TNCNLQQVGTEFSRKPYAIAVQSGHILKDKISSAILMLLNERRLETLKEKWWTDNPNKVSCPDSS 779

  Fly   798 DQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKK--------QNALEITQVRPVNDSSGS 853
            |: :||:::::|||||..|.|:.|:::||..|..|||:|        |..||:.|.:.|..:...
Worm   780 DESDGISIQNIGGVFIVILAGIALSIVTLAFEYYYYKRKARKAAEKEQEELEMKQSQQVVPNGFH 844

  Fly   854 GGNSSTAPPTATSTTK 869
            ........|..|:.||
Worm   845 TNGVKQDAPKLTNGTK 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	176/419 (42%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	139/311 (45%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	27/124 (22%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	175/414 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810