DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and glr-5

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	975	Identity:	222/975 - (22%)
Similarity:	386/975 - (39%)	Gaps:	251/975 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 WIEPVQRAEF-DTDIAM----VLKELDALRLDVKVDD--------------TTLTLTRSEDGLD- 69
            |:.  ||..: |.|:.:    ||...||::...|:.:              ....|.|..|.||
Worm    49 WLS--QRGIYGDIDLVIEYIDVLDHYDAIKKACKMLEKDHIVALLGGSHAALNAQLERITDDLDI 111

  Fly    70 --MQRFCEILSTVGAS------------AVIDLTYSHWE--------EGYNLVRSLGIGYVRLER 112
              :....::.:.:|.|            ||:|: ::||.        ||...:|       |||:
Worm   112 PFLTAIDDLRTDMGKSKIDFWPRPQLFEAVVDM-FTHWRWNRIVLVYEGDERIR-------RLEQ 168

  Fly   113 IM--------RPFLDMF--GDFMRQKRANNV-------------------AMVFMNARDA----V 144
            ::        |.:|...  ||:|  |.|..|                   .:|.||....    :
Worm   169 LLESEEYASIRFYLIKVHDGDYM--KAARQVKELEECRLLHKKDCSEFSRLLVDMNPEHTYTFLL 231

  Fly   145 EAMQQMLVGYPFRTLI--MDASQTDPGQHFLERIRSLRPAP---TYIA----LFARAAAMNGIFE 200
            .::|..|:......|:  |:.|..|.........|.:.|.|   |::.    .|..:.....|.|
Worm   232 ASLQMGLIELKHWFLLTNMELSTMDMELFRYNHARFISPYPVDSTFLTENRDAFNFSHFKEHITE 296

  Fly   201 K-VQKADLFQRPLEWHFVFLDTRDRVFKYRRQ-AELCTRFTLN--PRAICRSMPMPDLYCGSGFT 261
            | ..|.|..:.......||  |.|.|:.:... .||.:...:|  |:.:||...........|.:
Worm   297 KWAMKTDNSRNLKMMEAVF--TFDAVYAFANVFNELSSHMQMNDVPQTLCRKSSRNSRKYQHGRS 359

  Fly   262 MQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNF----- 321
            :...::.|.|..|....:...|:||.                               |||
Worm   360 LIDNIVHNDLHGLSGDLRRLNGHPLK-------------------------------SNFSMRIQ 393

  Fly   322 -LAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRF 385
             |.|:..|..|  .|..|...:  .||:|.       ::|..|.....|      ::.:.|   .
Worm   394 LLGYSGRLDDI--GFWEPATNV--HVNMSG-------DSKAQLQRNVQV------SDELKP---H 438

  Fly   386 FRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGEL 450
            ||:.|....|:..|::..  .||..:..    :||:|||.:..||:.|.|.:.|.|.:.|..|
Worm   439 FRVTTIMERPYVMLKKNH--YELDANSK----FEGFCIDLLAELSKDLGFTYTIHAVKDGKYG-- 495

  Fly   451 NEL---GEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKP-VRRTSLF 511
            |:.   |.|||::|:::|||.:.|:|.|.:...|.|.:||..|:. ..||||..:.| .::..||
Worm   496 NDKYGNGSWDGMMGEILRGEAEMAVAPLTVNYRRSEAVDFTKPFL-SLGISILYKVPDDQQPDLF 559

  Fly   512 KFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNN------RQAYPYAC------------ 558
            .|:..|..::|.:|..:::...:.::|:...:||....|      .:.:|.|.
Worm   560 SFLNPLSWQIWTAIATSIITVTLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMS 624

  Fly   559 REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPV 623
            ..::...:.|:.|::....|....|:|:|.|:|...:|:|.:::::.:||||||.|||.|...|:
Worm   625 NNYSFWNTVWYVLSTMLKGGCDFGPRAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPI 689

  Fly   624 QSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQY 688
            ::|:.||.|:.|:|..::...|.|:|...:.|...                   ::|.| :|::
Worm   690 KNLDDLANQTTISYGTIRGGSTMQFFQESRIAAHV-------------------KMWQY-MKDK- 733

  Fly   689 GHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVA 753
             .:.:..|..           .|:...:.:||::.:|..::||..:|||||::|.|...:.|.:|
Worm   734 -DVFVTSNGK-----------GVERALSMNYAYLMESTSLEYETQQNCNLTQIGGVLGSKGYGIA 786

  Fly   754 VQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNC-----PLSEDQEGITLESLGGVFIA 813
            :.:.|...|.:|..||...|....|..|.|:| :|....|     .:..|:..:::.::.|:||.
Worm   787 LAKKSEWTDRISRQILLYAKRGIIEMKKTKWW-RSKGAACASTASAVKHDRFALSMYNVAGLFIT 850

  Fly   814 TLFGLVLAMMTLGMEVL----YYKKKQ------------------NALEITQVRPVNDSSGSGGN 856
            ...|:|||.:.:..|::    :..||:                  |:|...:.|....:..|.||
Worm   851 LGVGIVLAAIVVIFELIHRCHHIAKKEGKPFLEELLYELRFALNMNSLSDHRSRQKMSTCNSNGN 915

Fly 857 856
Worm 916 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	113/424 (27%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	74/320 (23%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	84/417 (20%)
		ANF_receptor	38..377	CDD:279440	70/341 (21%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	114/423 (27%)
		Lig_chan	568..855	CDD:278489	74/320 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910