Protein Alignment Ir8a and glr-4

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001254126.1
• Gene: glr-4 / 174258
• WormBaseID: WBGene00001615
• Length: 951
• Species: Caenorhabditis elegans
• Alignment Length: 1003
• Identity: 219/1003 - (21%)
• Similarity: 384/1003 - (38%)
• Gaps: 313/1003 - (31%)

  Fly    71 QRFCEILSTVGASAVIDLTYSHWEEGYNLVRS---------LGIGYVRLERIMRPFLDMFG---- 122
            :|.|||:.. |..||: |:....|:...|::|         |.:....|...:..|:.:.|
 Worm    78 ERMCEIMQQ-GIVAVV-LSNEESEQDSQLIKSMCHYFNIPCLSLQSTSLRDSVSDFVTLLGPSRG 140

  Fly   123 -------DFMRQKRANNVAMVFMNARDAVEAMQQML------------VGYPFRTLIMDASQTDP 168
                   :|:...|.....:.:.:..| :|.:..::            :....|.|   .:.||.
 Worm   141 AGARATSEFLDSMRWTGFLLAYQHGSD-LEDLSPLMQYKQIVDTGGRRIHIKIRRL---PNNTDD 201

  Fly   169 GQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAE 233
            .:.||:.:::.......|........:..:.::.:..::.:.|  :.:||.:|
 Worm   202 YEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPP--FSYVFTNT------------ 252

  Fly   234 LCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASS 298
                               ||          ::|.:.|.::..|:           ..||.|...
 Worm   253 -------------------DL----------SLLEDFLNNMYGAS-----------FHCNITGLQ 277

  Fly   299 SEVSDPLEKDD--------YNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSS 355
            ...:||:.|..        |.....::....|.:||.        ||.:             ...
 Worm   278 LVKNDPMMKTQLALTSEAVYVVGMSIYRMRELGHAPR--------QSSI-------------MCD 321

  Fly   356 EHEAKTDLAAWSSVGEMRLLNETISPAR------------------------------RFFRIGT 390
            .|:      .||   :.|::||.|...:                              :|.::|.
 Worm   322 SHD------IWS---DGRIMNEGIRKLKLRNQLTGDVQFKSNGERDDIMYHGVGRINSQFVKLGN 377

  Fly   391 -AESIPWSYLRREEGTGEL-----IRDRSGLPI------------------WEGYCIDFIIRLSQ 431
             :|...|::..|.....|.     ..|..||.:                  :||:|||.:..::|
 Worm   378 WSEKRGWNFDSRYANRWEFDIDPDSEDLEGLHLRVVVYLEEPFVIKTGENQYEGFCIDLLNEMTQ 442

  Fly   432 KLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTG 496
            .|.|.:.|:..:.|..|..:|.|.|:|::|.|.|.|.|.:::|:.:...|.||:||..|:. ..|
 Worm   443 VLKFNYTIIEVQDGTYGIEDESGRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFM-HLG 506

  Fly   497 ISIAIRKPVRRT---SLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRN--------- 549
            |||.:.:....|   ||:.|:..|.|.||:|::.:....:..:..:.|:|||...|
 Worm   507 ISILLARTSEETDKGSLWTFLEPLSLTVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDF 571

  Fly   550 ----NRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANL 610
                |::      .:||:..||||.:.|...||....|:|.:.|::...:|:|..::::::||.|
 Worm   572 ENIKNQK------NQFTVLNSFWFTMGSLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQL 630

  Fly   611 AAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLY-RMWKELALNASKDF 674
            |||||||||.||::|.:.||.|.:|.|.|:|...|..:|...|.   .:| |||.
 Worm   631 AAFLTVERMSTPIESTQDLANQQKIRYGVLKSGSTMDFFRESKI---PMYERMWS---------- 682

  Fly   675 KKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNC 736
                               .:.||.|   |..::||.|.|   ::..||::.:|:.::|.:.|:|
 Worm   683 -------------------VMESSSPGVFVNSSREGIARV---KSGGYAYMMESSMLEYYLERDC 725

  Fly   737 NLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYW-NQSNLPNC--PLSED 798
            .|..:|.:...:.|.:|:.:||.|.|.||..:|:||:....|.||.|:| ::...|:|  |.||.
 Worm   726 ELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEK 790

  Fly   799 QEGITLESLGGVFIATLFGLVLAMM--------------------TLGMEVLYYK------KKQN 837
            ......:::.|:|...|.||::|.:                    .:|..:.:|:      |:::
 Worm   791 ATNSKPQNIFGIFYVLLTGLIVAFLLACGEYCIESRHEAFRLKLTIVGKFMDWYRGNSNDSKQRS 855

  Fly   838 ALEITQVRPVNDSSGSGGNSSTA--PPTATSTTKQAWHIPVLEAEEKPAKVS------------- 887
            .|...|:    |::|...:.||.  |||...        |.|.:...|.::|
 Worm   856 KLRNMQL----DTAGQEVSISTRHDPPTPPQ--------PALTSRPDPTRLSISSPAPTICVVSC 908

  Fly   888 ---------PPPSFETATFR--GKKLPA 904
                     .|||...|..|  .:.|||
 Worm   909 DDGTPISRDRPPSISRAGLRRLSRMLPA 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	130/477 (27%)
		Lig_chan	520..818	CDD:278489	92/317 (29%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	57/396 (14%)
		ANF_receptor	45..365	CDD:279440	54/376 (14%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	120/406 (30%)
		Lig_chan	533..810	CDD:278489	92/317 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010