Protein Alignment Ir8a and glr-4

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001254126.1
• Gene: glr-4 / 174258
• WormBaseID: WBGene00001615
• Length: 951
• Species: Caenorhabditis elegans
• Alignment Length: 1003
• Identity: 219/1003 - (21%)
• Similarity: 384/1003 - (38%)
• Gaps: 313/1003 - (31%)

  Fly    71 QRFCEILSTVGASAVIDLTYSHWEEGYNLVRS---------LGIGYVRLERIMRPFLDMFG---- 122
            :|.|||:.. |..||: |:....|:...|::|         |.:....|...:..|:.:.|
 Worm    78 ERMCEIMQQ-GIVAVV-LSNEESEQDSQLIKSMCHYFNIPCLSLQSTSLRDSVSDFVTLLGPSRG 140

  Fly   123 -------DFMRQKRANNVAMVFMNARDAVEAMQQML------------VGYPFRTLIMDASQTDP 168
                   :|:...|.....:.:.:..| :|.:..::            :....|.|   .:.||.
 Worm   141 AGARATSEFLDSMRWTGFLLAYQHGSD-LEDLSPLMQYKQIVDTGGRRIHIKIRRL---PNNTDD 201

  Fly   169 GQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAE 233
            .:.||:.:::.......|........:..:.::.:..::.:.|  :.:||.:|
 Worm   202 YEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPP--FSYVFTNT------------ 252

  Fly   234 LCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASS 298
                               ||          ::|.:.|.::..|:           ..||.|...
 Worm   253 -------------------DL----------SLLEDFLNNMYGAS-----------FHCNITGLQ 277

  Fly   299 SEVSDPLEKDD--------YNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSS 355
            ...:||:.|..        |.....::....|.:||.        ||.:             ...
 Worm   278 LVKNDPMMKTQLALTSEAVYVVGMSIYRMRELGHAPR--------QSSI-------------MCD 321

  Fly   356 EHEAKTDLAAWSSVGEMRLLNETISPAR------------------------------RFFRIGT 390
            .|:      .||   :.|::||.|...:                              :|.::|.
 Worm   322 SHD------IWS---DGRIMNEGIRKLKLRNQLTGDVQFKSNGERDDIMYHGVGRINSQFVKLGN 377

  Fly   391 -AESIPWSYLRREEGTGEL-----IRDRSGLPI------------------WEGYCIDFIIRLSQ 431
             :|...|::..|.....|.     ..|..||.:                  :||:|||.:..::|
 Worm   378 WSEKRGWNFDSRYANRWEFDIDPDSEDLEGLHLRVVVYLEEPFVIKTGENQYEGFCIDLLNEMTQ 442

  Fly   432 KLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTG 496
            .|.|.:.|:..:.|..|..:|.|.|:|::|.|.|.|.|.:::|:.:...|.||:||..|:. ..|
 Worm   443 VLKFNYTIIEVQDGTYGIEDESGRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFM-HLG 506

  Fly   497 ISIAIRKPVRRT---SLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRN--------- 549
            |||.:.:....|   ||:.|:..|.|.||:|::.:....:..:..:.|:|||...|
 Worm   507 ISILLARTSEETDKGSLWTFLEPLSLTVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDF 571

  Fly   550 ----NRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANL 610
                |::      .:||:..||||.:.|...||....|:|.:.|::...:|:|..::::::||.|
 Worm   572 ENIKNQK------NQFTVLNSFWFTMGSLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQL 630

  Fly   611 AAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLY-RMWKELALNASKDF 674
            |||||||||.||::|.:.||.|.:|.|.|:|...|..:|...|.   .:| |||.
 Worm   631 AAFLTVERMSTPIESTQDLANQQKIRYGVLKSGSTMDFFRESKI---PMYERMWS---------- 682

  Fly   675 KKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNC 736
                               .:.||.|   |..::||.|.|   ::..||::.:|:.::|.:.|:|
 Worm   683 -------------------VMESSSPGVFVNSSREGIARV---KSGGYAYMMESSMLEYYLERDC 725

  Fly   737 NLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYW-NQSNLPNC--PLSED 798
            .|..:|.:...:.|.:|:.:||.|.|.||..:|:||:....|.||.|:| ::...|:|  |.||.
 Worm   726 ELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEK 790

  Fly   799 QEGITLESLGGVFIATLFGLVLAMM--------------------TLGMEVLYYK------KKQN 837
            ......:::.|:|...|.||::|.:                    .:|..:.:|:      |:::
 Worm   791 ATNSKPQNIFGIFYVLLTGLIVAFLLACGEYCIESRHEAFRLKLTIVGKFMDWYRGNSNDSKQRS 855

  Fly   838 ALEITQVRPVNDSSGSGGNSSTA--PPTATSTTKQAWHIPVLEAEEKPAKVS------------- 887
            .|...|:    |::|...:.||.  |||...        |.|.:...|.::|
 Worm   856 KLRNMQL----DTAGQEVSISTRHDPPTPPQ--------PALTSRPDPTRLSISSPAPTICVVSC 908

  Fly   888 ---------PPPSFETATFR--GKKLPA 904
                     .|||...|..|  .:.|||
 Worm   909 DDGTPISRDRPPSISRAGLRRLSRMLPA 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	130/477 (27%)
glr-4	NP_001254126.1	Periplasmic_Binding_Protein_type1	30..385	CDD:471960	57/396 (14%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:473866	120/406 (30%)