DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and Grin3b

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	185/819 - (22%)
Similarity:	298/819 - (36%)	Gaps:	218/819 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 MRPFLDMFGDFMRQKRANNVAMVFMNARD-----------AVEAMQQMLVGYPFRTLIMDASQTD 167
            :...||:....:|.....::|:|....||           |.:|.:          .::|.|:.|
  Rat   155 LETILDVLVSLVRAHAWEDIALVLCRVRDPGSLVTLWTNHASQAPK----------FVLDLSRLD 209

  Fly   168 PGQHFLERIRSLR--------------PAPTYIALFARAAAMNGIFEKVQKAD--LFQRPLEWHF 216
                  .|..|||              |.|..:.|....|..:.:.|......  |...||
  Rat   210 ------SRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGPQWLLGTPL---- 264

  Fly   217 VFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRA-------MLLNVLRSL 274
                                     |.....:..:|......|.|.|.:       |:..|.::|
  Rat   265 -------------------------PAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQAL 304

  Fly   275 INAAQVSPG---YPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQ 336
            .:.|.|.|.   .|..:..|...|..|......|             :.||.        ...||
  Rat   305 SSMALVHPERALLPAVVNCDDLKTGGSEATGRTL-------------ARFLG--------NTSFQ 348

  Fly   337 SPVPGLTFAVNI--SAGYYSSEHEAKTDL-------AAWSSVGE--------------MRLLNET 378
                |.|.||.:  |:..:.|.|.....|       .||::||.              :|:.:.:
  Rat   349 ----GRTGAVWVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPS 409

  Fly   379 ISPARRFFRIGTAESIPWSYLRR--EEG---TGELIRD-----------------RSGLP----- 416
            .:.||...|:.|....|:.:.|.  |:|   .|:|..|                 ...:|
  Rat   410 GTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRR 474

  Fly   417 IWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSER 481
            ...|||||.:.||::.|.|:||:.....|..|.|.: |.|.|:||||:.|....|:.:..:.|.|
  Rat   475 CCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRD-GRWTGLVGDLLAGRAHMAVTSFSINSAR 538

  Fly   482 EEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYS 546
            .:|:||..|:: .|.:.|.:|.....:.:..||..|...:|:.:.|||..||:.:...:..|||.
  Rat   539 SQVVDFTSPFF-STSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYG 602

  Fly   547 ----SRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFT 607
                .||....:.|: ....|..:..|..|.     ..:.||..:||.|:..:.:|.:|:|:::|
  Rat   603 LTPRGRNRGTVFSYS-SALNLCYAILFGRTV-----SSKTPKCPTGRFLMNLWAIFCLLVLSSYT 661

  Fly   608 ANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASK 672
            |||||.:..::      :.|:|:.        :.|...|......:|.  |::....|..:.||
  Rat   662 ANLAAVMVGDK------TFEELSG--------IHDPKLHHPSQGFRFG--TVWESSAEAYIKAS- 709

  Fly   673 DFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEIT--RN 735
                     :|  |.:.|:.   ..|.|.  ...|.|.:.:......|||.|.:.:.||::  .:
  Rat   710 ---------FP--EMHAHMR---RHSAPT--TPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDAD 758

  Fly   736 CNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE 800
            |.|..||:.||.:.|.:.:.|.|.|...||..|...:...|.:.|..|::..     .|..:...
  Rat   759 CKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKM-----VPCGKRVF 818

  Fly   801 GITLESL-------GGVFIATLFGLVLAMMT-LGMEVLY 831
            .:| |:|       .|:|:....||..|::| ||..|.|
  Rat   819 AVT-ETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFY 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	113/435 (26%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	73/310 (24%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	56/319 (18%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	113/434 (26%)
		Lig_chan	576..842	CDD:278489	73/310 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000