Protein Alignment Ir8a and Grin2c

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 1033
• Identity: 229/1033 - (22%)
• Similarity: 346/1033 - (33%)
• Gaps: 307/1033 - (29%)

  Fly    48 LRLDVKVDDTTLTLTRSEDGLDMQRFCEILS--------TVGASAVIDLTYSHWEEGYNLVRSLG 104
            |:|.|.::.....|.:..:..|...|..|.|        ..|..||.|.:|..|.....|...||
Mouse   202 LQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELG 266

  Fly   105 IG--YVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDA----VEAMQQMLVGYPFRTLIMDA 163
            .|  ..|.:|:           :||..| .|.:.:.:..:|    .||.|..|||
Mouse   267 PGGPRARTQRL-----------LRQVDA-PVLVAYCSREEAEVLFAEAAQAGLVG---------- 309

  Fly   164 SQTDPGQHFLERIRSL--RPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRV- 225
                ||..:|....:|  ..||.       ||...|:...|.::        |.   |..|.:|
Mouse   310 ----PGHVWLVPNLALGSTDAPP-------AAFPVGLISVVTES--------WR---LSLRQKVR 352

  Fly   226 ----------FKYRRQAELCTRFTL-NPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAA- 278
                      ..||||..     || .|...|||.|.|.......|          .|.|:|..
Mouse   353 DGVAILALGAHSYRRQYG-----TLPAPAGDCRSHPGPVSPAREAF----------YRHLLNVTW 402

  Fly   279 -----QVSPG----YPLAIYQDCNATASSSEVSDPLEKDDYNWLDMV-HWSNFLAYA--PPLPHI 331
                 ..|||    .|..:....|.               :...:|| .|.:.:.|.  |..|..
Mouse   403 EGRDFSFSPGGYLVQPTMVVIALNR---------------HRLWEMVGRWDHGVLYMKYPVWPRY 452

  Fly   332 QDQFQSPVPG--LTFAVNISAGYYSSEH-EAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES 393
            ....|..|..  ||.|......:...|. :..|.....::|...|..|.|.|         :.:.
Mouse   453 STSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFS---------SGDI 508

  Fly   394 IPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDG 458
            .|::.|                 ..:|:|||.:.:|::.:.|.:::.....|..|: ...|.|:|
Mouse   509 TPYTKL-----------------CCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGK-RVRGVWNG 555

  Fly   459 VVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW- 522
            ::|::.....|.||.:|.:..||.|:|||..|:.| ||||:.:.:.....|...|:......||
Mouse   556 MIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVE-TGISVMVARSNGTVSPSAFLEPYSPAVWV 619

  Fly   523 LSIVAALVGTAIMIWFMDKYSPYSSRNN-----RQAYPYACREFTLRESFW--FALTSFTPQGGG 580
            :..|..|...||.::..:.:||.|...|     :...|    .||:.:|.|  :||. |......
Mouse   620 MMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKSGGP----SFTIGKSVWLLWALV-FNNSVPI 679

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE------------------ 627
            |.|:..:.:::|..:..|.|:.||::|||||||:..|:....|..|.
Mouse   680 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGT 744

  Fly   628 ----QLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQY 688
                ...|..|.||   :|..||....|.:..||.|    ..|.:.|.
Mouse   745 VPNGSTERNIRSNY---RDMHTHMVKFNQRSVEDAL----TSLKMGAR----------------- 785

  Fly   689 GHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAEQP 749
             |:...::                       |||:|:|.:.|...::  |.|..:  |:|||...
Mouse   786 -HVSRKLD-----------------------AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTG 826

  Fly   750 YAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGITLESLGGVFIAT 814
            |.:|:|:.||....:..|:|:...|...::|:. .|......|.........:.::::.|||...
Mouse   827 YGIAMQKDSHWKRAIDLALLQFLGDGETQKLET-VWLSGICHNEKNEVMSSKLDIDNMAGVFYML 890

  Fly   815 LFGLVLAMMTLGMEVLYYKK--------------------------------------------- 834
            |..:.||::....|.|.|.|
Mouse   891 LVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLTAG 955

  Fly   835 --KQNALEITQVR----PVNDSSGS----------GGNSSTAPPTATSTTKQAWHIPVLEAEEKP 883
              :.|.|::.|..    ...|.|||          .||:..||...||..:..  .|....:..|
Mouse   956 SAQANVLKMLQAARDMVSTADVSGSLDRATRTIENWGNNRRAPAPTTSGPRSC--TPGPPGQPSP 1018

  Fly   884 AKVSPPPSFET-ATFRGKKLPARITLGDGKFKP-------RHGLYAR--RNLGASDSH 931
            :...||....| ...|..:.|||.....|..:|       ||...||  ..:|...||
Mouse  1019 SGWRPPGGGRTPLARRAPQPPARPATCAGSPQPDVSRASCRHAWDARWPVRVGHQGSH 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	102/436 (23%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	70/317 (22%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	113/487 (23%)
		NMDAR2_C	905..>980	CDD:463148	8/74 (11%)