DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and Grin2b

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	908	Identity:	192/908 - (21%)
Similarity:	338/908 - (37%)	Gaps:	233/908 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VQRAEF----DTDIAMVLKELDALRLDVKV------DDTTL-TLTRSEDGLDMQRFCEILSTVGA 82
            |.|.|.    :||...::..:..|..|.|:      |||.. .:.:..|.:..|....||...|.
Mouse    65 VPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGG 129

  Fly    83 SAVI----DLTYSHWEEGYNLVRSLGIGYVRLER-------IMRPFLDMFGDFMRQKRANNVAMV 136
            |::|    |.:...::.|.::.:...:....:|.       |:..:...:.||:.:.|:
Mouse   130 SSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRS------ 188

  Fly   137 FMNARDAVEAMQQMLVGYPF-RTLIMDASQTDPG---QHFLERIRS-------LRPAPTYIALFA 190
                     .::...||:.. ..|::|.|..|..   |:.|::::|       .:...|||...|
Mouse   189 ---------TIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVA 244

  Fly   191 RAAAMNG-----IFEKVQKADLFQRPL------------EWHF-VFLDTRDRVFKYRRQAELCT- 236
            .:..:.|     |...:...|....|.            ||.: :....||.:      |.:.|
Mouse   245 NSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGI------AIITTA 303

  Fly   237 --------RFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGY---PLAIYQ 290
                    .|...|::.|.:.....:|..:   |....|:||.....|.:....||   |..:..
Mouse   304 ASDMLSEHSFIPEPKSSCYNTHEKRIYQSN---MLNRYLINVTFEGRNLSFSEDGYQMHPKLVII 365

  Fly   291 DCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSS 355
            ..|.......|.        .|.|......:..:....|..::|....:..:|.
Mouse   366 LLNKERKWERVG--------KWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTL----------- 411

  Fly   356 EHEAKTDLAAWSSVGEM--RLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIW 418
             .||...:.  .||..:  ..:..|:...:|.......:..| .|:::               ..
Mouse   412 -EEAPFVIV--ESVDPLSGTCMRNTVPCQKRIISENKTDEEP-GYIKK---------------CC 457

  Fly   419 EGYCIDFIIRLSQKLNFEFEIVAPEVG-HMGELNELGEWDGVVGDLVRGETDFAIAALKMYSERE 482
            :|:|||.:.::|:.:.|.:::.....| |..::|  |.|:|::|::|......|:.:|.:..||.
Mouse   458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGKKIN--GTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   483 EVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWFMDKYSPYS 546
            ||:||..|:.| ||||:.:.:.....|...|:.....:|| :..|..|:.:|:.::..:.:||..
Mouse   521 EVVDFSVPFIE-TGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG 584

  Fly   547 SRNNRQAYPYAC----RE-----FTLRESFW----FALTSFTPQGGGEAPKAISGRMLVAAYWLF 598
              .||      |    ||     ||:.::.|    ....:..|.   :.||..:.:::|:.:..|
Mouse   585 --YNR------CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPV---QNPKGTTSKIMVSVWAFF 638

  Fly   599 VVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMW 663
            .|:.||::|||||||:..|.....|..|.                       :.||
Mouse   639 AVIFLASYTANLAAFMIQEEYVDQVSGLS-----------------------DKKF--------- 671

  Fly   664 KELALNASKDFK-KFRIWDYP-------IKEQYG--HILLAINSSQPVADA----KEGFANVDAH 714
                 ....||. .||....|       |:..|.  |..:...:.:.|.||    |.|  .:|
Mouse   672 -----QRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTG--KLD-- 727

  Fly   715 ENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAEQPYAVAVQQGSHLGDELSYAILELQKDR 775
                 |||:|:|.:.|...|:  |.|..:  |:|||...|.:|:|:.|....::..|||:|..|.
Mouse   728 -----AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDG 787

  Fly   776 FFEELKAKYW------NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYY 832
            ..|||:| .|      |:.|    .:...|  :.::::.|||......:.|:::|...|.|:|
Mouse   788 EMEELEA-LWLTGICHNEKN----EVMSSQ--LDIDNMAGVFYMLGAAMALSLITFICEHLFY 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	109/441 (25%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	82/335 (24%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	64/354 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	115/490 (23%)
		NMDAR2_C	840..1482	CDD:402274	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910