DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and Grin1

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	NP_001359487.1	Gene:	Grin1 / 14810	MGIID:	95819	Length:	959	Species:	Mus musculus

Alignment Length:	897	Identity:	190/897 - (21%)
Similarity:	338/897 - (37%)	Gaps:	258/897 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KELDALRLDVK-VDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIG 106
            |.:.||.::.: ::...:.|:.|||        :..:...|:|::::|              |.|
Mouse   223 KNVTALLMEARDLEARVIILSASED--------DAATVYRAAAMLNMT--------------GSG 265

  Fly   107 YVRL--ERIMRPFLDMFGDFMRQKRANNVAMVFMNAR-------DAVEAMQQMLVGYPFRTLIMD 162
            ||.|  ||      ::.|:.:|......:.:..:|.:       |||..:.|.:     ..|:..
Mouse   266 YVWLVGER------EISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAV-----HELLEK 319

  Fly   163 ASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVF- 226
            .:.|||.:..:......:..|.:..:...:...:|:..:|:              |.:..||.|
Mouse   320 ENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVE--------------FNEDGDRKFA 370

  Fly   227 KYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQD 291
            .|                             |...:|...|:.|  .:.|...|.|       .|
Mouse   371 NY-----------------------------SIMNLQNRKLVQV--GIYNGTHVIP-------ND 397

  Fly   292 CNATASSSEVSDPLEKDDYNWLDMV--HWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYS 354
            ........|...|........|.:|  |...|: |..|                   .:|.|...
Mouse   398 RKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFV-YVKP-------------------TMSDGTCK 442

  Fly   355 SEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLP-IW 418
            .|.....|                  |.::....|..::.|.|             .|..:| ..
Mouse   443 EEFTVNGD------------------PVKKVICTGPNDTSPGS-------------PRHTVPQCC 476

  Fly   419 EGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELG-----EWDGVVGDLVRGETDFAIAALKMY 478
            .|:|:|.:|:|::.:||.:|:.....|..|....:.     ||:|::|:|:.|:.|..:|.|.:.
Mouse   477 YGFCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTIN 541

  Fly   479 SEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYS 543
            :||.:.|:|..|:..| |::|.::|.:.|::|..||...:..:||.:..::...|:|::.:|::|
Mouse   542 NERAQYIEFSKPFKYQ-GLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFS 605

  Fly   544 PY------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGE-APKAISGRMLVAAYWLFVVL 601
            |:      |......|       .||..:.||:.......|.|| ||::.|.|:|...:..|.::
Mouse   606 PFGRFKVNSEEEEEDA-------LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 663

  Fly   602 MLATFTANLAAFLTVERMQTPVQSLE--QLARQS-RINYTVVKDSDTHQYFVNMKFAEDTLYRMW 663
            ::|::||||||||.::|.:..:..:.  :|...| :..|..||.|....|| ..:....|:||..
Mouse   664 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYF-RRQVELSTMYRHM 727

  Fly   664 KELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEI 728
            :                    |..|.....||   |.|.|            |..:|||.|||.:
Mouse   728 E--------------------KHNYESAAEAI---QAVRD------------NKLHAFIWDSAVL 757

  Fly   729 KYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYW-------N 786
            ::|.::.|:|...||:|....:.:.:::.|.....:|.:||:..::.|.|:|. |.|       :
Mouse   758 EFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLD-KTWVRYQECDS 821

  Fly   787 QSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLY-----YKKKQNALEITQVRP 846
            :||.|        ..:|.|::.|||:....|:|..:..:.:|:.|     .::||..|....|
Mouse   822 RSNAP--------ATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAV-- 876

  Fly   847 VNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFR 898
                                   ..|...:  .:.|..:..|.|. :.||||
Mouse   877 -----------------------NVWRKNL--QDRKSGRAEPDPK-KKATFR 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	109/425 (26%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	80/314 (25%)
Grin1	NP_001359487.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	44/265 (17%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	120/499 (24%)
		Ion_trans_2	<622..677	CDD:369572	21/54 (39%)
		CaM_bdg_C0	856..884	CDD:371136	6/54 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910