DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and Grik5

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	1131	Identity:	257/1131 - (22%)
Similarity:	421/1131 - (37%)	Gaps:	347/1131 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTT---------LTL 61
            |:|||.:.||...                       .:.|.:||:...:||.|         |.|
Mouse     5 LLLLLIVAFANPS-----------------------CQVLSSLRMAAILDDQTVCGRGERLALAL 46

  Fly    62 TRSE---------------DGLDMQR---------FCEIL------------STVGASAV----- 85
            .|.:               |..::||         .|:||            |...||.|
Mouse    47 AREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICG 111

  Fly    86 ---------------------------------IDLTYSHWEEGYN-----LVRSLGIGYVRLER 112
                                             :.|..|...:.:|     |:.:.....:|||.
Mouse   112 EKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEE 176

  Fly   113 IMRPFL--------DMFGD------FMRQKRANNVAMVFMNARDAVEAMQQML-------VGYPF 156
            ::|.||        .|..|      .:::.|.:.|:.:.::|..::..:...|       :|:|
Mouse   177 LVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFP- 240

  Fly   157 RTL------IMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFE---KVQKADLF--QR 210
            |:|      ::.||:......|.:.|.:....|        ...::||.|   .:....:|  ..
Mouse   241 RSLPLGLSCVLQASELGMTSAFYKYILTTMDFP--------ILHLDGIVEDSSNILGFSMFNTSH 297

  Fly   211 PLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLI 275
            |....||    |.....:|...|..|            .|.|.|.....|.... ::::.:|.|
Mouse   298 PFYPEFV----RSLNMSWRENCEAST------------YPGPALSAALMFDAVH-VVVSAVREL- 344

  Fly   276 NAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVP 340
            |.:|.....|||        .:|:.:. |......|:|.||.:.....        :.:|.|...
Mouse   345 NRSQEIGVKPLA--------CTSANIW-PHGTSLMNYLRMVEYDGLTG--------RVEFNSKGQ 392

  Fly   341 GLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRL--------LNETISPARRFFRIGTAESIPWS 397
            ...:.:.|    .....:...::..|.|...:.:        |::|:  |.:...:.|....|
Mouse   393 RTNYTLRI----LEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTL--ANKTLVVTTILENP-- 449

  Fly   398 YLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGD 462
            |:.|......|    ||...:||:|:|.:..|::.|.|.:.:...|.|..|.....|.|.|:||:
Mouse   450 YVMRRPNFQAL----SGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGE 510

  Fly   463 LV-RGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPV-RRTSLFKFMTVLRLEVWLSI 525
            |: |.:.|.|:||..:.:|||:||||..|:. ..||||..|..: |:...|.|:......|||.:
Mouse   511 LINRQKADLAVAAFTITAEREKVIDFSKPFM-TLGISILYRVHMGRKPGYFSFLDPFSPAVWLFM 574

  Fly   526 VAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC---------REFTLRESFWFALTSFTPQGGGE 581
            :.|.:..:.:::...:.|||...|     |:.|         .::||..|.||.:..|..||...
Mouse   575 LLAYLAVSCVLFLAARLSPYEWYN-----PHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEI 634

  Fly   582 APKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTH 646
            .|:|:|.|.:...:|.|.:::::::||||||||||:||:.||:|.:.||.|:.|.|..:....|.
Mouse   635 MPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTM 699

  Fly   647 QYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGF 708
            .:|.|.::  .|..|||..:                             .|.||   |...:||.
Mouse   700 TFFQNSRY--QTYQRMWNYM-----------------------------QSKQPSVFVKSTEEGI 733

  Fly   709 ANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQK 773
            |.|   .|:.|||:.:|...:|....|||||::|.:...:.|.:.:..||...||::.|||:||:
Mouse   734 ARV---LNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQE 795

  Fly   774 DRFFEELKAKYWNQSNLPNCPLSEDQ--EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKK- 835
            :...|.||.|:|...   .||..||.  :|:.:|::||:|:..:.||::|:....||.::..::
Mouse   796 NNRLEILKRKWWEGG---RCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRS 857

  Fly   836 ---------QNALE--------------------------ITQVRPVND---------SSGSGGN 856
                     |..|:                          :..:|.|.:         |:|:||:
Mouse   858 AESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGD 922

  Fly   857 SST-----------APP-----------TATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRG 899
            :..           .||           |.....::...|..|.|....|    ||       ||
Mouse   923 AGAHGGPQRLLDDPGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGA----PP-------RG 976

  Fly   900 KKLPARITLGDGKFKPRHGLYARRNL 925
            ...||..|   ...:||.|....|.|
Mouse   977 LGTPAEAT---SPPRPRPGPTGPREL 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	129/416 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	95/311 (31%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	76/448 (17%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	129/416 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810