Protein Alignment Ir8a and Grik1

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_006522977.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 866
• Identity: 216/866 - (24%)
• Similarity: 338/866 - (39%)
• Gaps: 266/866 - (30%)

  Fly    84 AVIDLT-YSHWEEGYNLVRSLGIGYVRLERIMR-PFLDMFGDFMRQKRANNVAMVFMNARDAVEA 146
            ||:||. |.:|:. ..:|.....|.:||:.::: |........:||..:.|        :||...
Mouse   160 AVLDLVLYYNWKT-VTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGN--------KDAKPL 215

  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRP 211
            :::|..|..| .:|.|.|.                         ..||      ::.|..||...
Mouse   216 LKEMKKGKEF-YVIFDCSH-------------------------ETAA------EILKQILFMGM 248

  Fly   212 L-EWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLI 275
            : |::..|..|.|             .|.|:          .:||..||..|....|||:
Mouse   249 MTEYYHYFFTTLD-------------LFALD----------LELYRYSGVNMTGFRLLNI----- 285

  Fly   276 NAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVP 340
                                 .:..||..:||          ||.....|||.|.
Mouse   286 ---------------------DNPHVSSIIEK----------WSMERLQAPPRPE---------- 309

  Fly   341 GLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETIS--------PAR---RFFRIGTAESI 394
                 ..:..|..::|.....|.....::...|....|:|        |.|   ||..:  .:..
Mouse   310 -----TGLLDGVMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNL--IKEA 367

  Fly   395 PWSYLR----------------------REEGT----GELI------------------------ 409
            .|..|.                      :||||    ||:.
Mouse   368 RWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDG 432

  Fly   410 -RDRS---------------------------------GLPIWEGYCIDFIIRLSQKLNFEFEIV 440
             ||||                                 |...:||||:|.:..||..|.|.:::.
Mouse   433 NRDRSNNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVK 497

  Fly   441 APEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKP- 504
            ....|..|..|:.|||:|:|.:|:....|.|:|.|.:...||:||||..|:. ..||||..|||
Mouse   498 LVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFM-TLGISILYRKPN 561

  Fly   505 VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC--------REF 561
            .....:|.|:..|..::|:.::.|.:|.:.:::.:.:::||...|     |:.|        ..|
Mouse   562 GTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYN-----PHPCNPDSDVVENNF 621

  Fly   562 TLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSL 626
            ||..||||.:.:...||....|||:|.|::...:|.|.:::::::|||||||||||||::|:.|.
Mouse   622 TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSA 686

  Fly   627 EQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHI 691
            :.||:|::|.|..|:|..|..:|...|.:  |..:||   |..:|:
Mouse   687 DDLAKQTKIEYGAVRDGSTMTFFKKSKIS--TYEKMW---AFMSSR------------------- 727

  Fly   692 LLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQ 756
                ..|..|.::.||...|   ...|||.:.:|..|:|...||||||::|.:...:.|.|....
Mouse   728 ----QQSALVKNSDEGIQRV---LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPI 785

  Fly   757 GSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGITL--ESLGGVFIATLFGLV 819
            ||...|:::.|||:||::.....:|.|:|..:   .||..:.:|...|  |::||:||....|||
Mouse   786 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGN---GCPEEDSKEASALGVENIGGIFIVLAAGLV 847

  Fly   820 LAMMTLGMEVLYYKKKQNALE 840
            |::.....|.:|..:|.|.:|
Mouse   848 LSVFVAIGEFIYKSRKNNDIE 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	139/498 (28%)
		Lig_chan	520..818	CDD:278489	94/307 (31%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	69/387 (18%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	124/405 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810