Protein Alignment Ir8a and Grid2

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_032193.1
• Gene: Grid2 / 14804
• MGIID: 95813
• Length: 1007
• Species: Mus musculus
• Alignment Length: 817
• Identity: 192/817 - (23%)
• Similarity: 337/817 - (41%)
• Gaps: 189/817 - (23%)

  Fly    70 MQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVA 134
            :|.|.:.:|..|    :|:.....|...|.:.:.....:|:|.:.|     :.|.:|:      |
Mouse   181 IQEFLDKVSQQG----MDVALQKVENNINKMITTLFDTMRIEELNR-----YRDTLRR------A 230

  Fly   135 MVFMNARDA----VEAMQQMLVGYPFRTLIMDASQTDPGQHFLER--------IRSLRPAPTYIA 187
            ::.||...|    .|.::..||.:....:|::....|.....|.|        ||...|.|..|:
Mouse   231 ILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNIS 295

  Fly   188 LFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFK--YRRQAELCTRFTLNPR-AICRSM 249
                                               .|.|:  :|..:.||     :|: ...::|
Mouse   296 -----------------------------------QRCFRGNHRISSSLC-----DPKDPFAQNM 320

  Fly   250 PMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLD 314
            .:.:||           :.:.:..|.||..                         .:.:|..|..
Mouse   321 EISNLY-----------IYDTVLLLANAFH-------------------------KKLEDRKWHS 349

  Fly   315 MVHWSNFLAYAPPLPHIQDQFQS----PVPGLT----FAVN----------ISAGYYSSEHEAKT 361
            |...|.....:.|....:...::    .|.|||    |..|          :...|.........
Mouse   350 MASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVR 414

  Fly   362 DLAAWSSVGEMR--LLNETISPARR--FFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYC 422
            .|..|:.|..:.  |.::.:....|  ..|:.|....|: .:..|...|:..:       ::|:.
Mouse   415 KLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPF-VMVSENVLGKPKK-------YQGFS 471

  Fly   423 IDFIIRLSQKLNFEFEI-VAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVID 486
            ||.:..||..|.|.:|| |||:..: |...|.|.|:|:||:||....|..|:||.:..:||.|:|
Mouse   472 IDVLDALSNYLGFNYEIYVAPDHKY-GSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVD 535

  Fly   487 FLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNR 551
            |...|.:.: :.:.:|:..:...:|..:....|.:|..|...::...::::.::..:|...:..
Mouse   536 FTTRYMDYS-VGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMG- 598

  Fly   552 QAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616
                 :....||..|.||...||..|||......::.||::.|:|||.:::::::|||||||||:
Mouse   599 -----SMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTI 658

  Fly   617 ERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMK----FAEDTLY-RMWKELALNASKDFKK 676
            .|:::.:|||:.|::|:.|.|..|.||..:|: |.||    |..|::| :||:  .:|.|.
Mouse   659 TRIESSIQSLQDLSKQTDIPYGTVLDSAVYQH-VRMKGLNPFERDSMYSQMWR--MINRSN---- 716

  Fly   677 FRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITR--NCNLT 739
                               .|...|.:::.|...|   :..:|||:.|:|.::|....  :|:..
Mouse   717 -------------------GSENNVLESQAGIQKV---KYGNYAFVWDAAVLEYVAINDPDCSFY 759

  Fly   740 EVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPL--SED--QE 800
            .||...|::.|.:|:|.||...|..|..|||||:....:.||.|:|.::.  .|.|  |.|  |:
Mouse   760 TVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNG--QCDLYSSVDAKQK 822

  Fly   801 G--ITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKK 835
            |  :.::||.|||.....|:||:.:...:|..:.::|
Mouse   823 GGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRK 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	119/412 (29%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		40/254 (16%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	55/338 (16%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	118/410 (29%)
		Interaction with AP4M1. /evidence=ECO:0000250|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007