Protein Alignment Ir8a and Gria2

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 555
• Identity: 151/555 - (27%)
• Similarity: 266/555 - (47%)
• Gaps: 86/555 - (15%)

  Fly   342 LTFAVNISAGYYSSEHEAKTD----LAAWSSVGEMRLL-------NETISPARRFFRIGTAESIP 395
            :.:.:||.        |.||:    :..||.|.:|.:.       |:|.....:...:.|....|
Mouse   369 INYTINIM--------ELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESP 425

  Fly   396 WSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGV 459
            :..:::..   |::   .|...:||||:|....:::...|::::.....|..|..: :...|:|:
Mouse   426 YVMMKKNH---EML---EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGM 484

  Fly   460 VGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWL 523
            ||:||.|:.|.|||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:
Mouse   485 VGELVYGKADIAIAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548

  Fly   524 SIVAALVGTAIMIWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGG 580
            .||.|.:|.:::::.:.::|||        ..|..:.:  .:..||.:..|.||:|.:|..||..
Mouse   549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS--ESTNEFGIFNSLWFSLGAFMQQGCD 611

  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDT 645
            .:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.|::|:.|.|..:....|
Mouse   612 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGST 676

  Fly   646 HQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEG 707
            .::|...|.|.                 |.|  :|.|            :.|::|   |....||
Mouse   677 KEFFRRSKIAV-----------------FDK--MWTY------------MRSAEPSVFVRTTAEG 710

  Fly   708 FANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771
            .|.| ......||::.:|...:| |..:.|:..:||.....:.|.:|..:||.|...::.|:|:|
Mouse   711 VARV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKL 774

  Fly   772 QKDRFFEELKAKYW---NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYK 833
            .:....::||.|:|   .:....:....|....::|.::.|||...:.||.|||:...:|..|..
Mouse   775 SEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS 839

  Fly   834 KKQ--------NALEITQVR-PVNDSSGSGGNSST 859
            :.:        :|....:.| .:..|:|..|...|
Mouse   840 RAEAKRMKMTLSAATRNKARLSITGSTGENGRVMT 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	122/419 (29%)
		Lig_chan	520..818	CDD:278489	85/312 (27%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	9/36 (25%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	122/421 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910