Protein Alignment Ir8a and Grik4

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_780690.2
• Gene: Grik4 / 110637
• MGIID: 95817
• Length: 956
• Species: Mus musculus
• Alignment Length: 1022
• Identity: 235/1022 - (22%)
• Similarity: 407/1022 - (39%)
• Gaps: 262/1022 - (25%)

  Fly     3 LPLLVLLLA-----LRFAG----------SEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDV 52
            ||..:|::|     ||.|.          .|.|.||.....:.||.         :.|...:::|
Mouse    11 LPAWLLMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAP---------ERLGKAKVEV 66

  Fly    53 KVDDTTLTLTRSEDGLDMQRFCEIL-----------STVGASAVIDLTYSHWEEGYNLVRSLGIG 106
            .:    ..|.|..:....:..|:||           |:..:|::|.          |:.....:.
Mouse    67 DI----FELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIIS----------NICGEKEVP 117

  Fly   107 YVRL--ERIMRPFLDMFGDFMRQKRANNVAMV------FMNARDAV-------------EAMQQM 150
            :.::  |..:|..|..|..........::::.      |.|...|.             :.::|.
Mouse   118 HFKVAPEEFVRFQLQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQF 182

  Fly   151 LVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWH 215
            |:.....::.|.....|| ...|:.||..:.|.  |.:.|.|:..:.|..|.  |:|......:.
Mouse   183 LISKDTLSVRMLDDTRDP-TPLLKEIRDDKTAT--IIIHANASMSHTILLKA--AELGMVSAYYT 242

  Fly   216 FVFLDTR-----------DRV----FKYRRQA-----ELCTRFTLNPRAICRSMPMPDLYCGSGF 260
            ::|.:..           |||    |....|:     |.......:.:..|..:|.      :|.
Mouse   243 YIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPF------TGP 301

  Fly   261 TMQRAMLLNVLRSLINAAQ---------VSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMV 316
            .:..|:|.:.:.:::.|.|         |.|           .:..|:::          |....
Mouse   302 ALSSALLFDAVYAVVTAVQELNRSQEIGVKP-----------LSCGSAQI----------WQHGT 345

  Fly   317 HWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKT---DLAAWSSVGEMRLLNET 378
            ...|:|...            .:.|||..:..::....|.:..|.   ....:..:|:..:. |.
Mouse   346 SLMNYLRMV------------ELEGLTGHIEFNSKGQRSNYALKILQFTRNGFQQIGQWHVA-EG 397

  Fly   379 ISPARRFFRIGTAESI-------------PWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLS 430
            :|...|.:....::|:             |:..|:...      ::..|...:||:|:|.:..|:
Mouse   398 LSMDSRLYASNISDSLFNTTLVVTTILENPYLMLKGNH------QEMEGNDRYEGFCVDMLKELA 456

  Fly   431 QKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQT 495
            :.|.|.::|.....|..|.....|.|.|:||:|:..:.|.|:|.|.:.:|||:||||..|:. ..
Mouse   457 EILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFM-TL 520

  Fly   496 GISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC- 558
            ||||..|..: ||...|.|:......|||.::.|.:..:.:::.:.:.:||...:     |:.|
Mouse   521 GISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYS-----PHPCA 580

  Fly   559 --------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLT 615
                    .:::|..|.||.:..|..||...||:|:|.|.:...:|.|.:::::::|||||||||
Mouse   581 QGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLT 645

  Fly   616 VERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIW 680
            |:||:.|::|::.||.|:.|.|..:....:..:|.|.::  .|..|||..:
Mouse   646 VQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRY--QTYQRMWNYM-------------- 694

  Fly   681 DYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVG 742
                           .|.||   |...:||.|.|   .|::|||:.:|...:|...||||||::|
Mouse   695 ---------------YSKQPSVFVKSTEEGIARV---LNSNYAFLLESTMNEYYRQRNCNLTQIG 741

  Fly   743 EVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQ--EGITLE 805
            .:...:.|.:.:..||...||...|||:||::...|.||.|:|...   .||..||.  :|:.:|
Mouse   742 GLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGG---KCPKEEDHRAKGLGME 803

  Fly   806 SLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE-------ITQVRPV---NDS-----SGSGG 855
            ::||:|:..:.||::|:....:|.|:..:...|.|       :|::|.:   .|:     ..|||
Mouse   804 NIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMVTELRNIILCQDNIHPRRRRSGG 868

  Fly   856 NSSTAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKL 902
                .||..          |||| |.:|.        .|||....||
Mouse   869 ----LPPQP----------PVLE-ERRPR--------GTATLSNGKL 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	124/428 (29%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	71/445 (16%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	122/415 (29%)
		QRL_CxxC_CxxC	863..927	CDD:469521	16/53 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956