Protein Alignment Ir8a and grik1

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_004912220.1
• Gene: grik1 / 100493949
• XenbaseID: XB-GENE-957124
• Length: 928
• Species: Xenopus tropicalis
• Alignment Length: 974
• Identity: 230/974 - (23%)
• Similarity: 388/974 - (39%)
• Gaps: 260/974 - (26%)

  Fly     3 LPLLVLLLALR-FAGSEVLKITFWIEPVQRAEFDT-DIAMVLKELDALRLDVKVDDTTLTLTRSE 65
            ||.|..|.|:. .|..:||:|....|.|:....:. ::|......:..|....:.:||||
 Frog    27 LPFLCALAAITPQASQQVLRIGGIFETVENEPINVEELAFKFAVTNINRNRTLMPNTTLT----- 86

  Fly    66 DGLDMQRF------------CEILSTVGASAVIDLTYSHWEEG-YNLVRSLGIGYVRLERIMRPF 117
              .|:||.            |:.|: :|.:|:...::|..... .::..:|.:.::: .|...|.
 Frog    87 --YDIQRINLFDSFEASRRACDQLA-LGVAALFGPSHSSSVSAVQSICNALEVPHIQ-TRWKHPS 147

  Fly   118 LDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTD-----------PGQH 171
            :|....|......:..|:        ..|:.::::.|.::|:.:....:.           |.::
 Frog   148 VDNKDSFFINLHPDYAAI--------SRAVLELVLHYSWKTVTVVYEDSTGLIRLQELIKAPSRY 204

  Fly   172 FLE-RIRSL----RPAPTYIALFARAAAMNGIFEKVQK--ADLFQRPL------EWHFVFLDTRD 223
            .:: :||.|    :.|.|.:....::.....||:...:  |::.::.|      |::..|..|.|
 Frog   205 NIKIKIRQLPSGNKDARTLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMD 269

  Fly   224 RVFKYRRQAELCTRFTLNPRAICRSMPMPDL--YCGSGFTMQRAMLLNVLRSLINAAQVSPGYPL 286
                         .|.|            ||  |..||..|....|||:
 Frog   270 -------------LFAL------------DLEPYRYSGVNMTGFRLLNI---------------- 293

  Fly   287 AIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLP---------------------- 329
                      .:.:||..:||          ||.....|||.|
 Frog   294 ----------DNPQVSSVVEK----------WSMERLQAPPKPETGLLDGMMTTDAALMYDAVYM 338

  Fly   330 ------------------------HIQDQFQSPV-----PGLT--------------FAVNISA- 350
                                    ....:|.|.:     .|||              |.::|.:
 Frog   339 VAVATQRATQMTVSSLQCHRHKPWRFGPRFMSLIKEARWDGLTGRITFNRTDGLRRDFDMDIISL 403

  Fly   351 ---GYYSSEHEAKTDL-AAWSSVG--------------EMRLLNETISPARRFFRIGTAESIPWS 397
               |...:..|....| ..|..||              :.:..|.|.|.|.|...:.|....|:.
 Frog   404 KEDGMEKAAGETVNHLNKVWKKVGVWNSNTGLNMTDNLKDKSTNITDSLANRTLIVTTILEDPYV 468

  Fly   398 YLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGD 462
            ..|:.:      :...|...:||||:|.:..||..|.|.:|:.....|..|..|:.|||:|:|.:
 Frog   469 MFRKSD------KPLYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDGKYGAQNDKGEWNGMVRE 527

  Fly   463 LVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKP-VRRTSLFKFMTVLRLEVWLSIV 526
            |:..:.|.|:|.|.:...||:||||..|:. ..||||..||| .....:|.|:..|..::|:.::
 Frog   528 LIDHKADLAVAPLTITYVREKVIDFSKPFM-TLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVL 591

  Fly   527 AALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC--------REFTLRESFWFALTSFTPQGGGEAP 583
            .|.:|.:.:::.:.:::||...|     |:.|        ..|||..||||.:.:...||....|
 Frog   592 LACLGVSCVLFVIARFTPYEWYN-----PHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMP 651

  Fly   584 KAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQY 648
            ||:|.|::...:|.|.:::::::|||||||||||||::|:.|.:.||:|::|.|..|:|..|..:
 Frog   652 KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTF 716

  Fly   649 FVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDA 713
            |...|.:  |..:||                             ..::|.|..|..|.....:..
 Frog   717 FKKSKIS--TYEKMW-----------------------------AFMSSRQQTALVKNNDEGIQR 750

  Fly   714 HENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFE 778
            ....|||.:.:|..|:|...||||||::|.:...:.|.|....||...|:::.|||:||::....
 Frog   751 VLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 815

  Fly   779 ELKAKYWNQSNLPNCPLSEDQEGITL--ESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE 840
            .:|.|:|..:   .||..:.:|...|  |::||:||....||||::.....|.:|..:|.:.:|
 Frog   816 MMKEKWWRGN---GCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIE 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	126/411 (31%)
grik1	XP_004912220.1	PBP1_iGluR_Kainate	46..439	CDD:380605	74/470 (16%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:473866	126/411 (31%)