DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and grik1

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	974	Identity:	230/974 - (23%)
Similarity:	388/974 - (39%)	Gaps:	260/974 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPLLVLLLALR-FAGSEVLKITFWIEPVQRAEFDT-DIAMVLKELDALRLDVKVDDTTLTLTRSE 65
            ||.|..|.|:. .|..:||:|....|.|:....:. ::|......:..|....:.:||||
Frog    27 LPFLCALAAITPQASQQVLRIGGIFETVENEPINVEELAFKFAVTNINRNRTLMPNTTLT----- 86

  Fly    66 DGLDMQRF------------CEILSTVGASAVIDLTYSHWEEG-YNLVRSLGIGYVRLERIMRPF 117
              .|:||.            |:.|: :|.:|:...::|..... .::..:|.:.::: .|...|.
Frog    87 --YDIQRINLFDSFEASRRACDQLA-LGVAALFGPSHSSSVSAVQSICNALEVPHIQ-TRWKHPS 147

  Fly   118 LDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTD-----------PGQH 171
            :|....|......:..|:        ..|:.::::.|.::|:.:....:.           |.::
Frog   148 VDNKDSFFINLHPDYAAI--------SRAVLELVLHYSWKTVTVVYEDSTGLIRLQELIKAPSRY 204

  Fly   172 FLE-RIRSL----RPAPTYIALFARAAAMNGIFEKVQK--ADLFQRPL------EWHFVFLDTRD 223
            .:: :||.|    :.|.|.:....::.....||:...:  |::.::.|      |::..|..|.|
Frog   205 NIKIKIRQLPSGNKDARTLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMD 269

  Fly   224 RVFKYRRQAELCTRFTLNPRAICRSMPMPDL--YCGSGFTMQRAMLLNVLRSLINAAQVSPGYPL 286
                         .|.|            ||  |..||..|....|||:
Frog   270 -------------LFAL------------DLEPYRYSGVNMTGFRLLNI---------------- 293

  Fly   287 AIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLP---------------------- 329
                      .:.:||..:||          ||.....|||.|
Frog   294 ----------DNPQVSSVVEK----------WSMERLQAPPKPETGLLDGMMTTDAALMYDAVYM 338

  Fly   330 ------------------------HIQDQFQSPV-----PGLT--------------FAVNISA- 350
                                    ....:|.|.:     .|||              |.::|.:
Frog   339 VAVATQRATQMTVSSLQCHRHKPWRFGPRFMSLIKEARWDGLTGRITFNRTDGLRRDFDMDIISL 403

  Fly   351 ---GYYSSEHEAKTDL-AAWSSVG--------------EMRLLNETISPARRFFRIGTAESIPWS 397
               |...:..|....| ..|..||              :.:..|.|.|.|.|...:.|....|:.
Frog   404 KEDGMEKAAGETVNHLNKVWKKVGVWNSNTGLNMTDNLKDKSTNITDSLANRTLIVTTILEDPYV 468

  Fly   398 YLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGD 462
            ..|:.:      :...|...:||||:|.:..||..|.|.:|:.....|..|..|:.|||:|:|.:
Frog   469 MFRKSD------KPLYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDGKYGAQNDKGEWNGMVRE 527

  Fly   463 LVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKP-VRRTSLFKFMTVLRLEVWLSIV 526
            |:..:.|.|:|.|.:...||:||||..|:. ..||||..||| .....:|.|:..|..::|:.::
Frog   528 LIDHKADLAVAPLTITYVREKVIDFSKPFM-TLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVL 591

  Fly   527 AALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC--------REFTLRESFWFALTSFTPQGGGEAP 583
            .|.:|.:.:::.:.:::||...|     |:.|        ..|||..||||.:.:...||....|
Frog   592 LACLGVSCVLFVIARFTPYEWYN-----PHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMP 651

  Fly   584 KAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQY 648
            ||:|.|::...:|.|.:::::::|||||||||||||::|:.|.:.||:|::|.|..|:|..|..:
Frog   652 KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTF 716

  Fly   649 FVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDA 713
            |...|.:  |..:||                             ..::|.|..|..|.....:..
Frog   717 FKKSKIS--TYEKMW-----------------------------AFMSSRQQTALVKNNDEGIQR 750

  Fly   714 HENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFE 778
            ....|||.:.:|..|:|...||||||::|.:...:.|.|....||...|:::.|||:||::....
Frog   751 VLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 815

  Fly   779 ELKAKYWNQSNLPNCPLSEDQEGITL--ESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE 840
            .:|.|:|..:   .||..:.:|...|  |::||:||....||||::.....|.:|..:|.:.:|
Frog   816 MMKEKWWRGN---GCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIE 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	126/411 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	91/307 (30%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	76/472 (16%)
		ANF_receptor	61..404	CDD:279440	65/420 (15%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	126/411 (31%)
		Lig_chan	585..854	CDD:278489	91/307 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000