Protein Alignment Ir8a and grin2b

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 1040
• Identity: 210/1040 - (20%)
• Similarity: 374/1040 - (35%)
• Gaps: 308/1040 - (29%)

  Fly    35 DTDIAMVLKELDALRLDVKV------DDTTL-TLTRSEDGLDMQRFCEILSTVGASAVI----DL 88
            ::|...::..:..|..|.||      |||.. .:.:..|.:.:|....||...|.|::|    :.
 Frog    70 ESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEE 134

  Fly    89 TYSHWEEGYNLVRSLGIGYVRLER-------IMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEA 146
            ....::.|.::.:...:....:|.       |:..:...:.||..:.|:               .
 Frog   135 ASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRS---------------T 184

  Fly   147 MQQMLVGYPFRTLI-MDASQTDPG---QHFLERIRS-------LRPAPTYIALFARAAAMNG--- 197
            ::...||:....:| :|.|..|..   |:.|::::|       .:...|||...|.:..:.|
 Frog   185 IENSFVGWELEEVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGY 249

  Fly   198 --IFEKVQKADLFQRPL------------EWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRS 248
              |...:...|....|.            ||.:      |...:.|....:.|.......:...|
 Frog   250 TWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDY------DLPARVRDGIAIITTAASTMLSEHNS 308

  Fly   249 MPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWL 313
            :|.....|           .|:..|.:..|.:...|.:      |.|.....:|  ..:|.|
 Frog   309 IPQSKSSC-----------YNIQESRVYEAHMLKRYLI------NVTFEGRNLS--FSEDGY--- 351

  Fly   314 DMVH-------------WSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYY----------SS 355
             .:|             |.....|       :|:            ::...||          |.
 Frog   352 -QMHPKLVIILLNQQRKWERVGKY-------KDR------------SLKMKYYVWPVFELYPNSE 396

  Fly   356 EHE------AKTDLAAWSSVGEMRLLNETIS----PARRFFRIGTAESIPWSYLRREEGTGELIR 410
            ||:      ...:.|.:..|.::..|:.|..    |.|:..|...         |.|||...:.|
 Frog   397 EHKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRTEN---------RTEEGGNYIKR 452

  Fly   411 DRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVG-HMGELNELGEWDGVVGDLVRGETDFAIAA 474
                  ..:|:|||.:.::::.:.|.:::.....| |..::|  |.|:|::|::|......|:.:
 Frog   453 ------CCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKIN--GTWNGMIGEVVTKRAYMAVGS 509

  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWF 538
            |.:..||.||:||..|:.| ||||:.:.:.....|...|:.....:|| :..|..|:.:|:.::.
 Frog   510 LTINEERSEVVDFSVPFIE-TGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFV 573

  Fly   539 MDKYSPYSSRNNRQAYPYAC----RE-----FTLRESFW----FALTSFTPQGGGEAPKAISGRM 590
            .:.:||..  .||      |    ||     ||:.::.|    ....:..|.   :.||..:.::
 Frog   574 FEYFSPVG--YNR------CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPV---QNPKGTTSKI 627

  Fly   591 LVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE----------------------QLARQS 633
            :|:.:..|.|:.||::|||||||:..|.....|..|.                      ...|..
 Frog   628 MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNI 692

  Fly   634 RINYTVVKDSDTHQYFV--NMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAIN 696
            |.||.     :.|.|.|  |.:..:|.|      |:|...|
 Frog   693 RNNYL-----EMHSYMVKFNQRSVQDAL------LSLKTGK------------------------ 722

  Fly   697 SSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAEQPYAVAVQQG 757
                          :|       |||:|:|.:.|...|:  |.|..:  |:|||...|.:|:|:.
 Frog   723 --------------LD-------AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKD 766

  Fly   758 SHLGDELSYAILELQKDRFFEELKAKYW------NQSNLPNCPLSEDQEGITLESLGGVFIATLF 816
            |....::..|||:|..|...|||:| .|      |:.|    .:...|  :.::::.|||.....
 Frog   767 SGWKRQVDLAILQLFGDGEMEELEA-LWLTGICHNEKN----EVMSSQ--LDIDNMAGVFYMLAA 824

  Fly   817 GLVLAMMTLGMEVLYYKKKQNA-LEITQVRPVNDSSGSGG-------------NSSTAPPTATST 867
            .:.|:::|..||.|::.:.::. :.:...:|....|.|.|             .|:...|:||..
 Frog   825 AMALSLITFIMEHLFFWQLRHCFMGVCSGKPGVVFSISRGIYSCIHGVPIEDRQSAMNSPSATMN 889

  Fly   868 TKQAWHIPVLEAEEKPAKVS----PPPSF------ETATFRGKKLPARITLGDGK-FKPRHGLYA 921
            ...:..:.:|...:..|.:|    .|.|.      |::.:...:.....|..|.| |:|...|::
 Frog   890 NTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSFQPEENLFS 954

  Fly   922  921
             Frog   955  954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	110/451 (24%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	59/375 (16%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	115/485 (24%)
		NMDAR2_C	837..1449	CDD:463148	21/118 (18%)