DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and grin2b

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_017948700.2	Gene:	grin2b / 100490580	XenbaseID:	XB-GENE-949327	Length:	1449	Species:	Xenopus tropicalis

Alignment Length:	1040	Identity:	210/1040 - (20%)
Similarity:	374/1040 - (35%)	Gaps:	308/1040 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DTDIAMVLKELDALRLDVKV------DDTTL-TLTRSEDGLDMQRFCEILSTVGASAVI----DL 88
            ::|...::..:..|..|.||      |||.. .:.:..|.:.:|....||...|.|::|    :.
Frog    70 ESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEE 134

  Fly    89 TYSHWEEGYNLVRSLGIGYVRLER-------IMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEA 146
            ....::.|.::.:...:....:|.       |:..:...:.||..:.|:               .
Frog   135 ASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRS---------------T 184

  Fly   147 MQQMLVGYPFRTLI-MDASQTDPG---QHFLERIRS-------LRPAPTYIALFARAAAMNG--- 197
            ::...||:....:| :|.|..|..   |:.|::::|       .:...|||...|.:..:.|
Frog   185 IENSFVGWELEEVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGY 249

  Fly   198 --IFEKVQKADLFQRPL------------EWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRS 248
              |...:...|....|.            ||.:      |...:.|....:.|.......:...|
Frog   250 TWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDY------DLPARVRDGIAIITTAASTMLSEHNS 308

  Fly   249 MPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWL 313
            :|.....|           .|:..|.:..|.:...|.:      |.|.....:|  ..:|.|
Frog   309 IPQSKSSC-----------YNIQESRVYEAHMLKRYLI------NVTFEGRNLS--FSEDGY--- 351

  Fly   314 DMVH-------------WSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYY----------SS 355
             .:|             |.....|       :|:            ::...||          |.
Frog   352 -QMHPKLVIILLNQQRKWERVGKY-------KDR------------SLKMKYYVWPVFELYPNSE 396

  Fly   356 EHE------AKTDLAAWSSVGEMRLLNETIS----PARRFFRIGTAESIPWSYLRREEGTGELIR 410
            ||:      ...:.|.:..|.::..|:.|..    |.|:..|...         |.|||...:.|
Frog   397 EHKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRTEN---------RTEEGGNYIKR 452

  Fly   411 DRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVG-HMGELNELGEWDGVVGDLVRGETDFAIAA 474
                  ..:|:|||.:.::::.:.|.:::.....| |..::|  |.|:|::|::|......|:.:
Frog   453 ------CCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKIN--GTWNGMIGEVVTKRAYMAVGS 509

  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWF 538
            |.:..||.||:||..|:.| ||||:.:.:.....|...|:.....:|| :..|..|:.:|:.::.
Frog   510 LTINEERSEVVDFSVPFIE-TGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFV 573

  Fly   539 MDKYSPYSSRNNRQAYPYAC----RE-----FTLRESFW----FALTSFTPQGGGEAPKAISGRM 590
            .:.:||..  .||      |    ||     ||:.::.|    ....:..|.   :.||..:.::
Frog   574 FEYFSPVG--YNR------CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPV---QNPKGTTSKI 627

  Fly   591 LVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE----------------------QLARQS 633
            :|:.:..|.|:.||::|||||||:..|.....|..|.                      ...|..
Frog   628 MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNI 692

  Fly   634 RINYTVVKDSDTHQYFV--NMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAIN 696
            |.||.     :.|.|.|  |.:..:|.|      |:|...|
Frog   693 RNNYL-----EMHSYMVKFNQRSVQDAL------LSLKTGK------------------------ 722

  Fly   697 SSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAEQPYAVAVQQG 757
                          :|       |||:|:|.:.|...|:  |.|..:  |:|||...|.:|:|:.
Frog   723 --------------LD-------AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKD 766

  Fly   758 SHLGDELSYAILELQKDRFFEELKAKYW------NQSNLPNCPLSEDQEGITLESLGGVFIATLF 816
            |....::..|||:|..|...|||:| .|      |:.|    .:...|  :.::::.|||.....
Frog   767 SGWKRQVDLAILQLFGDGEMEELEA-LWLTGICHNEKN----EVMSSQ--LDIDNMAGVFYMLAA 824

  Fly   817 GLVLAMMTLGMEVLYYKKKQNA-LEITQVRPVNDSSGSGG-------------NSSTAPPTATST 867
            .:.|:::|..||.|::.:.::. :.:...:|....|.|.|             .|:...|:||..
Frog   825 AMALSLITFIMEHLFFWQLRHCFMGVCSGKPGVVFSISRGIYSCIHGVPIEDRQSAMNSPSATMN 889

  Fly   868 TKQAWHIPVLEAEEKPAKVS----PPPSF------ETATFRGKKLPARITLGDGK-FKPRHGLYA 921
            ...:..:.:|...:..|.:|    .|.|.      |::.:...:.....|..|.| |:|...|::
Frog   890 NTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSFQPEENLFS 954

Fly 922 921
Frog 955 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	110/451 (24%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	80/345 (23%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	59/375 (16%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	115/485 (24%)
		NMDAR2_C	837..1449	CDD:402274	21/118 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910